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alkaline mucus
- EXOCRINE
- mucous cells in stomach
- mechanical stimulation
- protects mucosa from chemical and mechanical damage
pepsinogen
- EXOCRINE
- chief cells in stomach
- stimulated by presence of ACh and gastrin
- begins protein digestion once activated to pepsin
HCl
- EXOCRINE
- parietal cells in stomach
- stimulated by ACh, gastrin, and histamine
- activates pepsinogen and aids in protein digestion
intrinsic factor
- EXOCRINE
- parietal cells in stomach
- stimulated by ACh, gastrin, and histamine
- facilitates absorption of B12
histamine
- ENDOCRINE
- ECL near pylorus
- stimulated by ACh and gastrin
- stimulates parietal cells (increase HCl secretion)
gastrin
- ENDOCRINE (GI hormone)
- G cells near pylorus
- stimulated by ACh and proteins
- stimulates parietal, chief, and ECL cells (all increase HCl/digestion)
- inhibited by accumulation of acid in stomach/duodenum and other factors that slow
gastric secretion
somatostatin
- ENODCRINE
- D cells near pylorus
- stimulated by the presence of acid in the antrum
- inhibits release of pancreatic secretions
secretin
- GI hormone
- stimulated by presence of acid in the duodenum
- inhibits gastric emptying, stimulates pancreatic duct cells to produce sodium bicarb to
neutralize acid in duodenum