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mature fully differentiated bone cells embedded in the bone are called
________________?
- osteocytes
- osteoblasts
- osteoclasts
- chondrocytes
- osteons
osteocytes
which phenotypic feature of the osteoclast defines the function of this cell type?
- triple helix
- ruffled border
- multinucleation
- expression of PTH receptor
- RGD sequence
ruffled border
alyssa is a student in VTPP 435 who has learned that Ca2+ ions are important for
muscle contraction and neuron function. Alyssa, age 21, hates milk and most
dairy products, and she doesn't eat many foods that are rich in calcium and she
does not believe in supplements. Why don't alyssa's muscles and nerves show
problems related to calcium deficiency?
- levels of calcium are high and suppressing bone resorption to maintain normal
serum Ca2+
- renal function is impaired and Ca2+ is being retained to maintain normal blood
levels
- sufficient Ca2+ in the skeleton that under the influence of PTH, releases Ca2+ to
maintain normal blood levels
- 1,25 dihydroxy vitamin D3 are decreased to suppress bone resorption and
maintain normal serum Ca2+
- poor diet is increasing estrogen levels to suppress bone resorption and
maintain normal serum Ca2+
sufficient Ca2+ in the skeleton that under the influence of PTH, releases Ca2+ to
maintain normal blood levels
what is the primary function of 1,25 dihydroxy vitamin D3?
- inhibit osteoclast bone resorption
- promote urinary excretion of phosphate
- stimulate new osteoblastic bone formation
- increase calcium and phosphate absorption
- decrease serum calcium
increase calcium and phosphate absorption
a 7-year-old in the ER and is reported to have a fractured femur, the result of a
bicycle accident. Admission x-ray reveals a comminuted femur fracture and
evidence of fractures of other long bones in various stages of healing. What do
, you suspect as the cause of the fracture?
- child abuse
- vitamin D deficiency
- osteogenesis imperfecta
- inadequate calcium intake
- hyperparathyroidism
child abuse
the 1st stage of fracture healing is ______________ and occurs within the first 48
hours after injury
- hematoma
- vascular invasion
- callus
- remodeling
- granuloma formation
hematoma
the physiologic action of PTH on target cells, such as osteoblasts involves the
action of:
- GPCR proteins
- non-receptor proteins
- lipids
- GPCR and non-receptor proteins
- nuclear receptor proteins and lipids
GPCR proteins
the bone disease osteoporosis is best describe by which of the following
hypothesis?
- insufficient intake of dietary calcium
- imbalance between bone formation and resorption
- poor intestinal calcium absorption
- decreased osteoclastic activity
- increased vitamin D levels
imbalance between bone formation and resorption
an elderly woman has the fracture pattern. Which medication she had been taking
to treat her post-menopausal osteoporosis?
- calcitonin
- estrogen
- bisphosphonate
- parathyroid hormone
- calcium and vitamin D
bisphosphonate
a fully differentiated osteoclast has receptors for which of the following proteins?
- PTH
- calcitonin
- 1,25 dihydroxy vitamin D3
- bone morphogenic protein
- interleukin-1
calcitonin