BN517 PHARMACOLOGY LESSONS 5-7 EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS GRADED A++
What is absorption?
Is the process of a drug moving from its site of administration into the bloodstream.
What is Metabolism?
Occurs most frequently in the liver and is the breakdown of drugs by enzymes and
determines the duration and intensity of a drug's pharmacologic action
What is distribution?
How a drug is transported into tissues
What is excretion
removal of drug from the body
What affects distribution of a drug in the body?
Blood supply
Drug solubility - lipid soluble drugs arrive faster
Body fluid compartments
Body weight
Fat composition
If a person had poor functioning kidneys what part of pharmokinetics would this
affect?
Elimination
What is the major organ of metabolism
, Liver
What is the major organ of excretion
Kidneys
What is Clearance?
The volume of blood cleared irreversibly of drug per unit time, expressed as litres per
hour (L/h) or millilitres per minute (mL/min)
What is volume of distribution?
the volume in which the amount of drug in the body would need to be uniformly
distributed to produces the observed (measured) concentration in blood.
Define Half Life
the time taken for the blood or plasma drug concentration to fall by one-half (50%)
Define bioavailability
the proportion of the administered dose that reaches the systemic circulation as intact
drug
What is pharmacodynamics?
process by which a drug works or affects the body
What is an agonist?
It is a drug that is capable of binding to, and activating, a receptor
What is an antagonist?
a drug that binds to a receptor but does not create an affect, but successfully stops
other drugs from binding.
What is an example of an agonist drug?
Morphine
ANSWERS WITH COMPLETE SOLUTIONS GRADED A++
What is absorption?
Is the process of a drug moving from its site of administration into the bloodstream.
What is Metabolism?
Occurs most frequently in the liver and is the breakdown of drugs by enzymes and
determines the duration and intensity of a drug's pharmacologic action
What is distribution?
How a drug is transported into tissues
What is excretion
removal of drug from the body
What affects distribution of a drug in the body?
Blood supply
Drug solubility - lipid soluble drugs arrive faster
Body fluid compartments
Body weight
Fat composition
If a person had poor functioning kidneys what part of pharmokinetics would this
affect?
Elimination
What is the major organ of metabolism
, Liver
What is the major organ of excretion
Kidneys
What is Clearance?
The volume of blood cleared irreversibly of drug per unit time, expressed as litres per
hour (L/h) or millilitres per minute (mL/min)
What is volume of distribution?
the volume in which the amount of drug in the body would need to be uniformly
distributed to produces the observed (measured) concentration in blood.
Define Half Life
the time taken for the blood or plasma drug concentration to fall by one-half (50%)
Define bioavailability
the proportion of the administered dose that reaches the systemic circulation as intact
drug
What is pharmacodynamics?
process by which a drug works or affects the body
What is an agonist?
It is a drug that is capable of binding to, and activating, a receptor
What is an antagonist?
a drug that binds to a receptor but does not create an affect, but successfully stops
other drugs from binding.
What is an example of an agonist drug?
Morphine
