NR565 Midterm Exam / NR 565 Advanced Pharmacolog v v v v v v v
y Care – Questions With Solutions
v v v v v
ASCVD Risk Score Correct Ans - Used in children aged 9-11 and 19-
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21, and adults every 5 years after 20, with greater risk for those with diabetes a
v v v v v v v v v v v v v v v
nd a risk score >7.5%
v v v v
Ezetimibe Use Correct Ans - v vvvvvvvvv v vv
Can be used in pregnancy/breastfeeding, as monotherapy or adjunct therapy
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with a statin or fibrate
v v v v
Ezetimibe Correct Ans - vvvvvvvvv v vv
Cholesterol Absorption Inhibitor that lowers cholesterol levels by decreasing
vvv v v v v v v v v v
absorption from the small intestine, without affecting triglycerides
v v v v v v v
Lifestyle Changes for High Cholesterol Correct Ans - Non-
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drug measures to lower LDL, including diet, exercise, weight control, and smoki
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ng cessation
v
Minimizing Side Effects Correct Ans - Non- v v vvvvvvvvv v vv vvv
statins like fibrates, ezetimibe, bile acid sequestrants, or statins for generally w
v v v v v v v v v v v
ell-tolerated side effects v v
Organic Nitrates Therapeutic Action Correct Ans -
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Direct relaxant effect on vascular smooth muscles, dilation of coronary vessel
vvv v v v v v v v v v v
s, reduction of preload and afterload, and promotion of vasodilation
v v v v v v v v v
Ranolazine Contraindications Correct Ans - v vvvvvvvvv v vv
Inhibited by CYP3A4 inhibitors, increasing the risk of torsades de pointes, incl
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uding grapefruit juice, HIV protease inhibitors, macrolide antibiotics, azole anti
v v v v v v v v v
fungal drugs, and some CCB v v v v
Statin Prescription Age v v vvvvvvvvv Correct Ans - Avoid in children under 10
v vv vvv v v v v
CCB Role in Variant Angina
v Correct Ans - v v v vvvvvvvvv v vv
Promotes relaxation of coronary artery spasm, increasing cardiac oxygen sup
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ply
, HF Worsening Symptoms Medication
v Correct Ans - v v vvvvvvvvv v vv
Aldosterone antagonist that promotes myocardial remodeling and fibrosis to
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help with symptoms v v
CCB Stable Angina Correct Ans -
v v vvvvvvvvv v vv
Promotes relaxation of peripheral arterioles, decreasing afterload and reduci
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ng cardiac oxygen demand
v v v
Nitro Patches Side Effect Response
v Correct Ans - v v v vvvvvvvvv v vv
Prescribe a BB to help with increased heart rate
vvv v v v v v v v v
CYP450 Inhibitors and Reducers Correct Ans -
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When not used correctly, they lead to increased side effects, adverse reactions
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, and toxicity
v v
Gouty Arthritis Treatment Decision
v Correct Ans - v v vvvvvvvvv v vv
In patients with infrequent flareups (less than three per year), NSAIDs are the
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first line agent for relieving pain
v v v v v
Gouty Arthritis NSAID Ineffectiveness
v Correct Ans - v v vvvvvvvvv v vv
Prescribe a glucocorticoid (prednisone) or make dietary changes
vvv v v v v v v v
Colchicine Long Term Treatment Correct Ans - v v v vvvvvvvvv v vv
Considered for long term treatment if a person has three or more gouty attack
vvv v v v v v v v v v v v v v
s per year
v v
Colchicine Contraindications Correct Ans - v vvvvvvvvv v vv
Should not be taken with statins or CYP3A4 inhibitors
vvv v v v v v v v v
Colchicine Adverse Effects Correct Ans - v v vvvvvvvvv v vv
Nausea, vomiting, diarrhea, myelosuppression, myopathy, and rhabdomyolys
vvv v v v v v v
is
Allopurinol Long Term Effect Correct Ans - v v v vvvvvvvvv v vv
Can lead to severe cutaneous adverse reaction (SCAR) with symptoms like ras
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h, fever, eosinophilia, and liver and kidney function issues
v v v v v v v v
Febuxostat Co-Administration Correct Ans - Should be co- v vvvvvvvvv v vv vvv v v
administered with NSAIDs or colchicine v v v v
y Care – Questions With Solutions
v v v v v
ASCVD Risk Score Correct Ans - Used in children aged 9-11 and 19-
v v vvvvvvvvv v vv vvv v v v v v v
21, and adults every 5 years after 20, with greater risk for those with diabetes a
v v v v v v v v v v v v v v v
nd a risk score >7.5%
v v v v
Ezetimibe Use Correct Ans - v vvvvvvvvv v vv
Can be used in pregnancy/breastfeeding, as monotherapy or adjunct therapy
vvv v v v v v v v v v v
with a statin or fibrate
v v v v
Ezetimibe Correct Ans - vvvvvvvvv v vv
Cholesterol Absorption Inhibitor that lowers cholesterol levels by decreasing
vvv v v v v v v v v v
absorption from the small intestine, without affecting triglycerides
v v v v v v v
Lifestyle Changes for High Cholesterol Correct Ans - Non-
v v v v vvvvvvvvv v vv vvv
drug measures to lower LDL, including diet, exercise, weight control, and smoki
v v v v v v v v v v v
ng cessation
v
Minimizing Side Effects Correct Ans - Non- v v vvvvvvvvv v vv vvv
statins like fibrates, ezetimibe, bile acid sequestrants, or statins for generally w
v v v v v v v v v v v
ell-tolerated side effects v v
Organic Nitrates Therapeutic Action Correct Ans -
v v v vvvvvvvvv v vv
Direct relaxant effect on vascular smooth muscles, dilation of coronary vessel
vvv v v v v v v v v v v
s, reduction of preload and afterload, and promotion of vasodilation
v v v v v v v v v
Ranolazine Contraindications Correct Ans - v vvvvvvvvv v vv
Inhibited by CYP3A4 inhibitors, increasing the risk of torsades de pointes, incl
vvv v v v v v v v v v v v
uding grapefruit juice, HIV protease inhibitors, macrolide antibiotics, azole anti
v v v v v v v v v
fungal drugs, and some CCB v v v v
Statin Prescription Age v v vvvvvvvvv Correct Ans - Avoid in children under 10
v vv vvv v v v v
CCB Role in Variant Angina
v Correct Ans - v v v vvvvvvvvv v vv
Promotes relaxation of coronary artery spasm, increasing cardiac oxygen sup
vvv v v v v v v v v v
ply
, HF Worsening Symptoms Medication
v Correct Ans - v v vvvvvvvvv v vv
Aldosterone antagonist that promotes myocardial remodeling and fibrosis to
vvv v v v v v v v v v
help with symptoms v v
CCB Stable Angina Correct Ans -
v v vvvvvvvvv v vv
Promotes relaxation of peripheral arterioles, decreasing afterload and reduci
vvv v v v v v v v v
ng cardiac oxygen demand
v v v
Nitro Patches Side Effect Response
v Correct Ans - v v v vvvvvvvvv v vv
Prescribe a BB to help with increased heart rate
vvv v v v v v v v v
CYP450 Inhibitors and Reducers Correct Ans -
v v v vvvvvvvvv v vv
When not used correctly, they lead to increased side effects, adverse reactions
vvv v v v v v v v v v v v
, and toxicity
v v
Gouty Arthritis Treatment Decision
v Correct Ans - v v vvvvvvvvv v vv
In patients with infrequent flareups (less than three per year), NSAIDs are the
vvv v v v v v v v v v v v v v
first line agent for relieving pain
v v v v v
Gouty Arthritis NSAID Ineffectiveness
v Correct Ans - v v vvvvvvvvv v vv
Prescribe a glucocorticoid (prednisone) or make dietary changes
vvv v v v v v v v
Colchicine Long Term Treatment Correct Ans - v v v vvvvvvvvv v vv
Considered for long term treatment if a person has three or more gouty attack
vvv v v v v v v v v v v v v v
s per year
v v
Colchicine Contraindications Correct Ans - v vvvvvvvvv v vv
Should not be taken with statins or CYP3A4 inhibitors
vvv v v v v v v v v
Colchicine Adverse Effects Correct Ans - v v vvvvvvvvv v vv
Nausea, vomiting, diarrhea, myelosuppression, myopathy, and rhabdomyolys
vvv v v v v v v
is
Allopurinol Long Term Effect Correct Ans - v v v vvvvvvvvv v vv
Can lead to severe cutaneous adverse reaction (SCAR) with symptoms like ras
vvv v v v v v v v v v v v
h, fever, eosinophilia, and liver and kidney function issues
v v v v v v v v
Febuxostat Co-Administration Correct Ans - Should be co- v vvvvvvvvv v vv vvv v v
administered with NSAIDs or colchicine v v v v
