BLD 434 EXAM QUESTIONS AND ANSWERS WITH COMPLETE
SOLUTIONS VERIFIED
List and define/explain the mechanisms of several factors described in the
textbook reading that have been proposed to be risk factors for autoimmune
disease development.
1) release of sequestered antigens by tissue damage
2) inflammation causing ectopic expressions of MHC class II on the cells that would not
normally express it
3) molecular mimicry
4) polycolonal B cell activation
5) inhibitory FcyR polymorphisms
6) genetic mutations in C1-C4
what is release of sequestered antigens by tissue damage
Intracellular proteins and nucleic acids that are released by traumatic damage into
extracellular fluid and elicit an inflammatory response at the same time
what is Inflammation causing ectopic expression of MHC Class II on cells that
would not normally express it?
IFN-y can cause several types of cell types to express MHC Class II in a cell-mediated
response to a virus. These cells may express a protein that is not made in the thymus
and hence there is no T cell tolerance to that protein.
what is molecular mimicry?
SOLUTIONS VERIFIED
List and define/explain the mechanisms of several factors described in the
textbook reading that have been proposed to be risk factors for autoimmune
disease development.
1) release of sequestered antigens by tissue damage
2) inflammation causing ectopic expressions of MHC class II on the cells that would not
normally express it
3) molecular mimicry
4) polycolonal B cell activation
5) inhibitory FcyR polymorphisms
6) genetic mutations in C1-C4
what is release of sequestered antigens by tissue damage
Intracellular proteins and nucleic acids that are released by traumatic damage into
extracellular fluid and elicit an inflammatory response at the same time
what is Inflammation causing ectopic expression of MHC Class II on cells that
would not normally express it?
IFN-y can cause several types of cell types to express MHC Class II in a cell-mediated
response to a virus. These cells may express a protein that is not made in the thymus
and hence there is no T cell tolerance to that protein.
what is molecular mimicry?
