BLD 434 - 6 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED

BLD 434 - 6 EXAM QUESTIONS AND ANSWERS WITH

COMPLETE SOLUTIONS VERIFIED


Grave's Disease

type 2 hypersensitivity

-auto antibodies: thyroid stimulating immunoglobulin (TSI)

-immune mechanism: TSI binds to TSH receptor on thyroid follicular cells, stimulating

thyroid hormone release

Types of hypersensitivity reactions

1. immediate (allergies)

2. antibody mediated

3. immune-complex mediated

4. delayed, cytotoxic

immediate hypersensitivity (allergies)

-IgE mediated

-mast cell degranulation (ex histamine)

-activates Th2 cells that produce cytokines to encourage isotype switching to IgE

-macrophage and basophil response to IgE

cytotoxic/antibody mediated hypersensitivity

antibody/antigen rxns and/or complement activation

immune complex mediated hypersensitivity

, -immune complexes are deposited

-activates complement and attracts inflammatory cells such as neutrophils

delayed hypersensitivity

-cell mediated

-sensitized T cells

-macrophage activation

timing for immediate vs delayed hypersensitivity

-immediate: 2 to 30 minutes

-delayed: 24 to 72 hours

total serum IgE testing

-radioimmunosorbent testing

-advantages: indicates propensity to develop IgE-mediated allergies

-disadvantages: not specific

allergen-specific lab testing

radioallergosorbent testing

-advantages: specifies allergen type

-disadvantage: no direct correlation between IgE t4est result and what happens during

patient reaction

skin prick testing

examines a person's in vivo response to allergen

-advantages: simple and easy, sensitive and specific, examines final final rxn to allergen

disadvantages: danger of systemic rxn aka anaphylaxis

type 2 hypersensitivity example