BLD 434: EXAM #2 QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
Which of the following is a characteristic of T-independent antibody responses?
Antibody produced is low affinity
What percent of individuals in a population need to be protected by vaccination in
order for herd immunity to exist for that pathogen?
95%
A lymphoid follicle containing a germinal center is called a:
Secondary lymphoid follicle
Which TFH cytokine would promote isotype switching to IgE by a B cell?
IL-4
Granzymes are a major component of:
Cytotoxic T lymphocyte granules
The poly-Ig receptor normally transports:
IgA
Which of the following cytokines causes a B cell to isotype switch to IgA?
TGF-β
Besides medullary epithelial cells, what other cell type is only located in the
medulla of the thymus?
Thymic dendritic cells
,Besides CD16 (FcγR-III), what other protein is present on the surface of human
NK cells?
CD56
For γδ T cells, identify whether they undergo either positive or negative selection.
Neither positive nor negative selection
There is 1 IEL for every ___ mucosal epithelial cells
7-10
The receptor NKG2D is an __________ receptor.
activating
Which of the following cytokines is released by Th1 to increase myelopoiesis?
GM-CSF
Besides BCR binding of antigen, what other signal does a B cell require to stay
alive in a germinal center?
CD40L binding to CD40
NK cells LACK CD3.
True
Abortive infections occur during:
protective immunity
What is the cytokine required to keep naïve B cells alive, and thus to maintain the
pool of circulating naïve B cells?
BAFF
Plasma cells are maintained in the bone marrow by stromal cells secreting:
IL-6
,If a human cell expresses HLA-E on its surface, an NK cell will:
Be inhibited and leave the cell alone
The main function of a plasma cell is:
To secrete large amounts of antigen-specific antibody
Strength of binding is important in testing ab TCR with self MHC in the thymus. A
T cell with strong binding to self MHC will:
Fail negative selection and undergo apoptosis
RhoGAM is a concentrated commercial preparation of:
IgG anti-Rh antibody
TGF-β is a "signature" cytokine secreted by:
Treg cells
What is the main function of integrins for immune cells?
High affinity adhesion
NKT cells respond to what kind of antigen?
Lipid antigen presented in CD1d
What is the main function of M cells?
sample gut bacteria
What cell triggers somatic hypermutation in an activated B lymphocyte? (i.e.
causes it to occur)
T helper cell
What is a disadvantage of a live-attenuated viral vaccine?
It can be dangerous for someone who is immunosuppressed
In B cell development, which gene undergoes somatic recombination first?
, Heavy chain
During T cell development, which TCR gene loci begin rearranging first?
β, γ, and δ
The second signal in the "two-signal hypothesis" comes from?
CD28 engagement by B7
What is the first reaction of naïve B and T lymphocytes to a new pathogen called?
Primary immunity
Receptor editing in developing B cells in the bone marrow is allowed to occur in
which gene locus/loci?
Light Chain
Which immune cells can kill by ADCC?
Nk cells
The two proteins VpreB and λ5 form the:
Surrogate light chain
Which of the following has lower expression on activated compared to naïve T
lymphocytes?
L-selectin
Which T effector secretes IL-4?
Th2
During childhood, which of the following isotypes of antibody produced by the
child is the last one to achieve serum concentrations similar to adults?
IgA
Which cytokine is essential to keep a T cell activated?
COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
Which of the following is a characteristic of T-independent antibody responses?
Antibody produced is low affinity
What percent of individuals in a population need to be protected by vaccination in
order for herd immunity to exist for that pathogen?
95%
A lymphoid follicle containing a germinal center is called a:
Secondary lymphoid follicle
Which TFH cytokine would promote isotype switching to IgE by a B cell?
IL-4
Granzymes are a major component of:
Cytotoxic T lymphocyte granules
The poly-Ig receptor normally transports:
IgA
Which of the following cytokines causes a B cell to isotype switch to IgA?
TGF-β
Besides medullary epithelial cells, what other cell type is only located in the
medulla of the thymus?
Thymic dendritic cells
,Besides CD16 (FcγR-III), what other protein is present on the surface of human
NK cells?
CD56
For γδ T cells, identify whether they undergo either positive or negative selection.
Neither positive nor negative selection
There is 1 IEL for every ___ mucosal epithelial cells
7-10
The receptor NKG2D is an __________ receptor.
activating
Which of the following cytokines is released by Th1 to increase myelopoiesis?
GM-CSF
Besides BCR binding of antigen, what other signal does a B cell require to stay
alive in a germinal center?
CD40L binding to CD40
NK cells LACK CD3.
True
Abortive infections occur during:
protective immunity
What is the cytokine required to keep naïve B cells alive, and thus to maintain the
pool of circulating naïve B cells?
BAFF
Plasma cells are maintained in the bone marrow by stromal cells secreting:
IL-6
,If a human cell expresses HLA-E on its surface, an NK cell will:
Be inhibited and leave the cell alone
The main function of a plasma cell is:
To secrete large amounts of antigen-specific antibody
Strength of binding is important in testing ab TCR with self MHC in the thymus. A
T cell with strong binding to self MHC will:
Fail negative selection and undergo apoptosis
RhoGAM is a concentrated commercial preparation of:
IgG anti-Rh antibody
TGF-β is a "signature" cytokine secreted by:
Treg cells
What is the main function of integrins for immune cells?
High affinity adhesion
NKT cells respond to what kind of antigen?
Lipid antigen presented in CD1d
What is the main function of M cells?
sample gut bacteria
What cell triggers somatic hypermutation in an activated B lymphocyte? (i.e.
causes it to occur)
T helper cell
What is a disadvantage of a live-attenuated viral vaccine?
It can be dangerous for someone who is immunosuppressed
In B cell development, which gene undergoes somatic recombination first?
, Heavy chain
During T cell development, which TCR gene loci begin rearranging first?
β, γ, and δ
The second signal in the "two-signal hypothesis" comes from?
CD28 engagement by B7
What is the first reaction of naïve B and T lymphocytes to a new pathogen called?
Primary immunity
Receptor editing in developing B cells in the bone marrow is allowed to occur in
which gene locus/loci?
Light Chain
Which immune cells can kill by ADCC?
Nk cells
The two proteins VpreB and λ5 form the:
Surrogate light chain
Which of the following has lower expression on activated compared to naïve T
lymphocytes?
L-selectin
Which T effector secretes IL-4?
Th2
During childhood, which of the following isotypes of antibody produced by the
child is the last one to achieve serum concentrations similar to adults?
IgA
Which cytokine is essential to keep a T cell activated?
