BLD 434 - 3 EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS VERIFIED
The first signal in the "two-signal hypothesis" comes from?
T cell TCR ==== Ag/MHC APC
The second signal in the "two-signal hypothesis" comes from?
T cell CD28 ==== B7 APC
TGF-β is a "signature" cytokine secreted by
Treg
Treg secretes
CTLA-4, IL-10, TGF-β
Tfh secretes
IL-21
Th17 secretes
IL-17, IL-6
Th2 secretes
IL-4, IL-5, IL-13
Th1 secretes
IL-2, INF-४, LT, TNF-α, CD40L
Tc secretes
IL-2, INF-४, LT
Which cytokine is essential to keep a T cell activated?
,IL-2
What cell triggers somatic hypermutation in an activated B lymphocyte? (i.e.
causes it to occur)
Th
A lymphoid follicle containing a germinal center is called
secondary follicle
Which of the following is the best definition of the AIRE protein?
broad transcription factor in the thymus`
do αβ T cells undergo negative and positive selection
yep
do γδ T cells undergo negative and positive selection
no
do b cells undergo negative and positive selection
just negative
During T cell development, which TCR gene loci begin rearranging first?
β, γ, and δ
Which of the following has lower expression on activated T cells compared to
naive ones
L-selectin
Which cytokine is released by Th1 to increase myelopoiesis?
TNF-α
Granzymes are a major component of:
Cytotoxic T lymphocyte granules
, Which of the B cell co-receptor complex proteins is a receptor for complement
C3d?
CD21
Besides BCR binding of antigen, what other signal does a B cell require to stay
alive in a germinal center?
CD40L binding to CD40
Which TFH cytokine would promote isotype switching to IgE by a B cell?
IL-4
What is the main function of integrins for immune cells?
high affinity adhesions
In B cell development, which gene undergoes somatic recombination first?
heavy
do pre-BCR and BCR use the same signaling molecules?
yep
The capacity to self-renew in the periphery is a characteristic of:
B1 B cells
What cell provides the necessary periodic growth factor to keep naïve mature B
lymphocytes alive in peripheral lymphoid circulation?
follicular dendritic cell
Receptor editing in developing B cells in the bone marrow is allowed to occur in
which gene locus/loci?
light chain
pre-BCR
COMPLETE SOLUTIONS VERIFIED
The first signal in the "two-signal hypothesis" comes from?
T cell TCR ==== Ag/MHC APC
The second signal in the "two-signal hypothesis" comes from?
T cell CD28 ==== B7 APC
TGF-β is a "signature" cytokine secreted by
Treg
Treg secretes
CTLA-4, IL-10, TGF-β
Tfh secretes
IL-21
Th17 secretes
IL-17, IL-6
Th2 secretes
IL-4, IL-5, IL-13
Th1 secretes
IL-2, INF-४, LT, TNF-α, CD40L
Tc secretes
IL-2, INF-४, LT
Which cytokine is essential to keep a T cell activated?
,IL-2
What cell triggers somatic hypermutation in an activated B lymphocyte? (i.e.
causes it to occur)
Th
A lymphoid follicle containing a germinal center is called
secondary follicle
Which of the following is the best definition of the AIRE protein?
broad transcription factor in the thymus`
do αβ T cells undergo negative and positive selection
yep
do γδ T cells undergo negative and positive selection
no
do b cells undergo negative and positive selection
just negative
During T cell development, which TCR gene loci begin rearranging first?
β, γ, and δ
Which of the following has lower expression on activated T cells compared to
naive ones
L-selectin
Which cytokine is released by Th1 to increase myelopoiesis?
TNF-α
Granzymes are a major component of:
Cytotoxic T lymphocyte granules
, Which of the B cell co-receptor complex proteins is a receptor for complement
C3d?
CD21
Besides BCR binding of antigen, what other signal does a B cell require to stay
alive in a germinal center?
CD40L binding to CD40
Which TFH cytokine would promote isotype switching to IgE by a B cell?
IL-4
What is the main function of integrins for immune cells?
high affinity adhesions
In B cell development, which gene undergoes somatic recombination first?
heavy
do pre-BCR and BCR use the same signaling molecules?
yep
The capacity to self-renew in the periphery is a characteristic of:
B1 B cells
What cell provides the necessary periodic growth factor to keep naïve mature B
lymphocytes alive in peripheral lymphoid circulation?
follicular dendritic cell
Receptor editing in developing B cells in the bone marrow is allowed to occur in
which gene locus/loci?
light chain
pre-BCR
