BLD 434 TOPIC 18 EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++
List the major differences between mucosal immunity and systemic immunity (in
the skin, for example).
Mucosal: activated immune cells normally present; inflammation is blocked
Systemic: few immune cells present normally in tissues; inflammation allows access
Describe the basic structure and chemical features of mucin that allow it to
protect mucosal tissue.
Huge glycoproteins composed of repeated subunits disulfide-bonded together; attached
glycan is sialic acid that creates a polyanionic surface, which can bind to negatively
charged proteins that keeps microbes out of the mucosal tissue, or in the event of
invasion it helps them to be removed quickly.
Describe the organization of Peyer's patches, being sure to identify abundant cell
types within them and the function of the M cells.
-Located in the GALT and act as a continuous immune response which is consistently
producing effector cells
-They are made up of an M Cell (micro-folded cell) which allows bacteria in via
pinocytosis, this is their soul purpose because M cells lack any kind of digestive
enzyme.
-Inside, there are immune cells such as dendritic cells, B cells, and T cells which can be
COMPLETE SOLUTIONS GRADED A++
List the major differences between mucosal immunity and systemic immunity (in
the skin, for example).
Mucosal: activated immune cells normally present; inflammation is blocked
Systemic: few immune cells present normally in tissues; inflammation allows access
Describe the basic structure and chemical features of mucin that allow it to
protect mucosal tissue.
Huge glycoproteins composed of repeated subunits disulfide-bonded together; attached
glycan is sialic acid that creates a polyanionic surface, which can bind to negatively
charged proteins that keeps microbes out of the mucosal tissue, or in the event of
invasion it helps them to be removed quickly.
Describe the organization of Peyer's patches, being sure to identify abundant cell
types within them and the function of the M cells.
-Located in the GALT and act as a continuous immune response which is consistently
producing effector cells
-They are made up of an M Cell (micro-folded cell) which allows bacteria in via
pinocytosis, this is their soul purpose because M cells lack any kind of digestive
enzyme.
-Inside, there are immune cells such as dendritic cells, B cells, and T cells which can be
