INTRODUCTORY CLINICAL
PHARMACOLOGY TEST.
1. A client is receiving oxybutynin for treatment of overactive bladder. The client also
takes haloperidol (Haldol) as an antipsychotic agent. What effect of the interaction of
these two drugs should the nurse observe for in the client?
A) Decreased effect of the antipsychotic drug
B) Increased risk for bleeding
C) Lowered plasma concentrations
D) Increased effect of the antispasmodic drug Answer: A Response:
The nurse should observe for decreased effectiveness of the antipsychotic drug in the
client as the effect of the interaction of the antispasmodic drug and haloperidol.
Increased risk for bleeding results from the interaction of oral anticoagulants with anti-
infective drugs. Increased effect of the antispasmodic drug occurs with the interaction of
an antispasmodic drug with a tricyclic antidepressant. Plasma concentrations are
lowered due to the interaction of fosfomycin, which is an anti-infective, with
metoclopramide, which is used to relieve gastric upset.
2. A nurse is providing care to a client diagnosed with benign prostatic hypertrophy. The
nurse understands that which of the following drugs inhibit the conversion of
testosterone into 5-alpha-dihydrotestosterone (DHT), resulting in a decrease in prostate
gland size? Select all that apply. A) Terazosin (Hytrin)
B) Finasteride (Proscar)
C) Methyltestosterone (Testred)
D) Dutasteride (Avodart)
E) Doxazosin (Cardura) Answer: B, D Response:
Finasteride (Proscar) and dutasteride (Avodart) inhibit the conversion of testosterone
into 5-alpha-dihydrotestosterone (DHT), which results in a decrease in prostate gland
size, making them useful in the treatment of benign prostatic hypertrophy.
3. Nurses who are pregnant or may become pregnant should not handle which drugs if
they are crushed or broken due to the drugs' substantial risk of abnormal growth to a
male fetus? Select all that apply. A) Methyltestosterone (Testred)
B) Finasteride (Proscar)
C) Testosterone (Striant)
D) Dutasteride (Avodart)
E) Oxandrolone (Oxandrin) Answer: B, D Response:
Women of childbearing age should not handle androgen hormone inhibitors, such as
finasteride (Proscar) or dutasteride (Avodart) tablets, if they are crushed or broken due
to the drugs' substantial risk of abnormal growth to a male fetus.
Page 2
, INTRODUCTORY CLINICAL
PHARMACOLOGY TEST.
4. Hormones may be used in cancer therapy, especially for advanced disease. Which of the
following are hormones used as antineoplastic drugs? Select all that apply.
A) Testolactone (Teslac)
B) Leuprolide (Lupron)
C) Megestrol (Megace)
D) Bicalutamide (Casodex)
E) Goserelin (Zoladex) Answer: A, B, C, E Response:
Testolactone (Teslac), leuprolide (Lupron), megestrol (Megace), bicalutamide
(Casodex), and goserelin (Zoladex) are hormones used as antineoplastic drugs.
5. A client with benign hypertrophy of the prostate has heard claims that the herb saw
palmetto can help relieve his symptoms. The client is eager to know more about this
herb. Which of the following pieces of information should the nurse provide the client
regarding the use of the herb?
A) Take the herb as tea, prepared in hot water.
B) Improvement can be seen within 2 to 3 weeks.
C) It may delay the need for prostatic surgery.
D) Stop the herb after 3 months of intake. Answer: C
Response:
The nurse should inform the client that saw palmetto might help delay the need for
prostatic surgery. The active components are not water soluble and should not be taken
as a tea. Improvement can be seen after 1 to 3 months of taking the herb, and not within
2 to 3 weeks. The herb intake should not be stopped after 3 months but should be
continued for 6 months, followed by evaluation by the health care provider.
6. After reviewing information about estrogens and their use, the instructor determines that
the teaching was successful when the students identify which of the following as true?
Select all that apply.
A) Changes in lipids levels occur with the use of estrogens.
B) Progestin use is recommended when estrogen is used after a hysterectomy.
C) Estrogen replacement therapy (ERT) helps to lessen the changes to the aging
tissues.
D) Estrogens increase a woman's risk for gallbladder disease.
E) The use of estrogens is associated with relatively few adverse reactions. Answer:
A, C, D Response:
Estrogens can relieve symptoms of menopause but can lead to blood pressure and lipid
changes. ERT can help lessen the changes to aging tissues, but the estrogen does
increase a woman's risk for gallbladder disease. The addition of progestin is
recommended when estrogen is used to treat menopausal symptoms in a woman with an
intact uterus. Estrogen alone may be used for estrogen replacement therapy after a
Page 3
PHARMACOLOGY TEST.
1. A client is receiving oxybutynin for treatment of overactive bladder. The client also
takes haloperidol (Haldol) as an antipsychotic agent. What effect of the interaction of
these two drugs should the nurse observe for in the client?
A) Decreased effect of the antipsychotic drug
B) Increased risk for bleeding
C) Lowered plasma concentrations
D) Increased effect of the antispasmodic drug Answer: A Response:
The nurse should observe for decreased effectiveness of the antipsychotic drug in the
client as the effect of the interaction of the antispasmodic drug and haloperidol.
Increased risk for bleeding results from the interaction of oral anticoagulants with anti-
infective drugs. Increased effect of the antispasmodic drug occurs with the interaction of
an antispasmodic drug with a tricyclic antidepressant. Plasma concentrations are
lowered due to the interaction of fosfomycin, which is an anti-infective, with
metoclopramide, which is used to relieve gastric upset.
2. A nurse is providing care to a client diagnosed with benign prostatic hypertrophy. The
nurse understands that which of the following drugs inhibit the conversion of
testosterone into 5-alpha-dihydrotestosterone (DHT), resulting in a decrease in prostate
gland size? Select all that apply. A) Terazosin (Hytrin)
B) Finasteride (Proscar)
C) Methyltestosterone (Testred)
D) Dutasteride (Avodart)
E) Doxazosin (Cardura) Answer: B, D Response:
Finasteride (Proscar) and dutasteride (Avodart) inhibit the conversion of testosterone
into 5-alpha-dihydrotestosterone (DHT), which results in a decrease in prostate gland
size, making them useful in the treatment of benign prostatic hypertrophy.
3. Nurses who are pregnant or may become pregnant should not handle which drugs if
they are crushed or broken due to the drugs' substantial risk of abnormal growth to a
male fetus? Select all that apply. A) Methyltestosterone (Testred)
B) Finasteride (Proscar)
C) Testosterone (Striant)
D) Dutasteride (Avodart)
E) Oxandrolone (Oxandrin) Answer: B, D Response:
Women of childbearing age should not handle androgen hormone inhibitors, such as
finasteride (Proscar) or dutasteride (Avodart) tablets, if they are crushed or broken due
to the drugs' substantial risk of abnormal growth to a male fetus.
Page 2
, INTRODUCTORY CLINICAL
PHARMACOLOGY TEST.
4. Hormones may be used in cancer therapy, especially for advanced disease. Which of the
following are hormones used as antineoplastic drugs? Select all that apply.
A) Testolactone (Teslac)
B) Leuprolide (Lupron)
C) Megestrol (Megace)
D) Bicalutamide (Casodex)
E) Goserelin (Zoladex) Answer: A, B, C, E Response:
Testolactone (Teslac), leuprolide (Lupron), megestrol (Megace), bicalutamide
(Casodex), and goserelin (Zoladex) are hormones used as antineoplastic drugs.
5. A client with benign hypertrophy of the prostate has heard claims that the herb saw
palmetto can help relieve his symptoms. The client is eager to know more about this
herb. Which of the following pieces of information should the nurse provide the client
regarding the use of the herb?
A) Take the herb as tea, prepared in hot water.
B) Improvement can be seen within 2 to 3 weeks.
C) It may delay the need for prostatic surgery.
D) Stop the herb after 3 months of intake. Answer: C
Response:
The nurse should inform the client that saw palmetto might help delay the need for
prostatic surgery. The active components are not water soluble and should not be taken
as a tea. Improvement can be seen after 1 to 3 months of taking the herb, and not within
2 to 3 weeks. The herb intake should not be stopped after 3 months but should be
continued for 6 months, followed by evaluation by the health care provider.
6. After reviewing information about estrogens and their use, the instructor determines that
the teaching was successful when the students identify which of the following as true?
Select all that apply.
A) Changes in lipids levels occur with the use of estrogens.
B) Progestin use is recommended when estrogen is used after a hysterectomy.
C) Estrogen replacement therapy (ERT) helps to lessen the changes to the aging
tissues.
D) Estrogens increase a woman's risk for gallbladder disease.
E) The use of estrogens is associated with relatively few adverse reactions. Answer:
A, C, D Response:
Estrogens can relieve symptoms of menopause but can lead to blood pressure and lipid
changes. ERT can help lessen the changes to aging tissues, but the estrogen does
increase a woman's risk for gallbladder disease. The addition of progestin is
recommended when estrogen is used to treat menopausal symptoms in a woman with an
intact uterus. Estrogen alone may be used for estrogen replacement therapy after a
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