C HAPTER 42: A NTIFUNGAL D RUGS
Lilley: Pharmacology and the Nursing Process, 10th Edition
MULTIPLE CHOICE
1. A patient is infected by invasive aspergillosis, and the medical history
reveals that the patient has not been able to tolerate several antifungal
drugs. The nurse anticipates an order for which medication to treat this
infection?
a. Fluconazole
b. Micafungin
c. Caspofungin
d. Nystatin
ANS: C
Caspofungin is used for treating sever e infection by Aspergillus
species (invasive aspergillosis) in patients who are intolerant of or
refractory to other drugs.
DIF: Cognitive Level: Understanding (Comprehension)
TOP: Nursing Process: Planning
MSC: NC LEX: Physiological Integrit y: Pharmacologi cal and
Parenteral Therapies
2. A patient with a severe fungal infection has orders for voriconazole. The
nurse is reviewing the patient ’s medical record and would be concerned if
which assessment finding is noted?
a. Decreased breath sounds in the lower lobes
b. Patient is also taking quinidine
, c. History of t ype 2 diabetes
d. Potassium level of 4.0 mEq/L
ANS: B
Voriconazole is contraindicated when co -administered with certain
other drugs metabolized by the cytochrome P -450 enz yme 3A4 (e.g.,
quinidine) because of the r isk for inducing serious cardiac
dysrhythmias.
DIF: Cognitive Level: Appl ying (Application)
TOP: Nursing Process: Assessment
MSC: NC LEX: Physiological Integrit y: Reduction of Risk
Potential
3. During therapy with amphotericin B, the nurse will monitor the pa tient for
known adverse effects that would be reflected by which laboratory result?
a. Serum potassium level of 2.7 mEq/L
b. Serum potassium level of 5.8 mEq/L
c. White blood cell count of 7000 cells/mm3
d. Platelet count of 300,000/microliter
ANS: A
The nurse needs to monitor for hypokalemia, a possible adverse effect
of amphotericin B. The other options are incorrect.
DIF: Cognitive Level: Anal yzing (Anal ysis)
TOP: Nursing Process: Implementation
MSC: NC LEX: Physiological Integrit y: Pharmacological and
Parenteral Th erapies
Lilley: Pharmacology and the Nursing Process, 10th Edition
MULTIPLE CHOICE
1. A patient is infected by invasive aspergillosis, and the medical history
reveals that the patient has not been able to tolerate several antifungal
drugs. The nurse anticipates an order for which medication to treat this
infection?
a. Fluconazole
b. Micafungin
c. Caspofungin
d. Nystatin
ANS: C
Caspofungin is used for treating sever e infection by Aspergillus
species (invasive aspergillosis) in patients who are intolerant of or
refractory to other drugs.
DIF: Cognitive Level: Understanding (Comprehension)
TOP: Nursing Process: Planning
MSC: NC LEX: Physiological Integrit y: Pharmacologi cal and
Parenteral Therapies
2. A patient with a severe fungal infection has orders for voriconazole. The
nurse is reviewing the patient ’s medical record and would be concerned if
which assessment finding is noted?
a. Decreased breath sounds in the lower lobes
b. Patient is also taking quinidine
, c. History of t ype 2 diabetes
d. Potassium level of 4.0 mEq/L
ANS: B
Voriconazole is contraindicated when co -administered with certain
other drugs metabolized by the cytochrome P -450 enz yme 3A4 (e.g.,
quinidine) because of the r isk for inducing serious cardiac
dysrhythmias.
DIF: Cognitive Level: Appl ying (Application)
TOP: Nursing Process: Assessment
MSC: NC LEX: Physiological Integrit y: Reduction of Risk
Potential
3. During therapy with amphotericin B, the nurse will monitor the pa tient for
known adverse effects that would be reflected by which laboratory result?
a. Serum potassium level of 2.7 mEq/L
b. Serum potassium level of 5.8 mEq/L
c. White blood cell count of 7000 cells/mm3
d. Platelet count of 300,000/microliter
ANS: A
The nurse needs to monitor for hypokalemia, a possible adverse effect
of amphotericin B. The other options are incorrect.
DIF: Cognitive Level: Anal yzing (Anal ysis)
TOP: Nursing Process: Implementation
MSC: NC LEX: Physiological Integrit y: Pharmacological and
Parenteral Th erapies
