Dermatopathology (Jani)
1. List three common malignant skin disorders?: 1. Basal cell Carcinoma
2. Squamous cell Carcinoma
3. Malignant Melanoma
2. The following skin conditions are classified as skin conditions?
-Urticaria
-Dermatitis (Acute and Chronic)
-Psoriasis
-Lichen Planus
-Bullous pemphigoid
-Dermatitis Herpetiformis: Inflammatory
3. are premalignant cutaneous lesions that may pro forms of carcinoma, andgress to
are a common skin condition that develo sun-exposed skin of individuals with cumulative ps in
exposure: Actinic (may present with irregular, red, scaly papules or plaques on sun-expo of the body)
keratosi
4. Actinic keratosis may progress to what type of carcinoma?: SCC s
5. List the five layers of the epidermis from deep to superficial?: 1. stratum basale. sed
2. stratum spinosum.
3. stratum granulosum.
4. stratum lucidum.
5. stratum corneum
6. List the two zones of the dermis from deep to superficial?: 1. The reticular dermis
2. The papillary dermis
7. The dermis is a tough but elastic support structure that houses nerves, blood vessels, lymphatics, and
cutaneous appendages such as?: 1. piloseba- ceous units (hair follicle, hair shaft and sebaceous gland)
2. eccrine
3. apocrine sweat glands
8. The is an important layer and plays a role in shock absorption, energy storage, and
maintenance of body heat: Subcutaneous/hypodermis - fat
9. T or F, please explain your answer:
The epidermis varies in thickness throughout the body depending mainly on frictional forces and is thinnest on th
palms of the hands and soles of the feet, and thickest in the face (eyelids) and genitalia.: False; thickest on hands +
soles, thinnest on eyelids, genitalia
10.Melanocytes are dendritic, pigment-producing cells located in the
layer of the epidermis where they manufacture melanin pigment: Basal
, Dermatopathology (Jani)
11.Langerhans cells are dendritic cells derived from the bone marrow in
the layer of the epidermis, with an immunologic function: stratum spinosum
12.T/F: Langerhans cells are identical to tissue macrophages and present antigens to lymphocytes.: True!
13.T/F: The basal cells or "stem cells" of the epidermis are undifferentiated, proliferating cells that migrate
upwards through all the five layers in a process known as keratinization which takes about 30 days for the cells to
migrate from the basal layer to cross the stratum corneum where they are finally shed.: T
14.T/F: The dermis is thicker (averages 1 to 4 mm) than the epidermis which is about as thin as piece of paper,
it is very thick on the back (almost 1 cm); it is very thin on the eyelid.: True
15.Where are Meissner's corpuscles located?: Papillary dermis
16. cells are needed for production of keratin protein, and are major sites for the
biosynthesis of soluble molecules (cytokines)
E. Specialized dermal cells (dendrocytes) are probably engineered for antigen presentation as well as for
production of molecules (e.g., factor XIIIa) capable of coordinating the assembly of macromolecular complexes
important in the early stages of healing of wounds affecting the deeper cutaneous layers.: - Squamous epithelial
17. are responsible for the production of a brown pigment (melanin) that represents an
important endogenous screen against harmful ultraviolet (UV) rays in sunlight.: Melanocytes
18. cells are epidermal dendritic cells that take up and process antigens and communicate
critical information to lymphoid cells.: Langerhans
19. cells that reside within the basal cell layer, may serve as mechanoreceptors or may
provide neuroendocrine function: Merkel
20. are probably engineered for antigen presentation as well as for production of molecules
(e.g., factor XIIIa) capable of coordinating the assembly of macromolecular complexes important in the early
stages of
healing of wounds affecting the deeper cutaneous layers.: Specialized dermal cells (dendrocytes)
21.Pigemented nevus or mole is a congenital or acquired neoplasm of what cells?: Melanocytes
22.Which of the following is a clinical feature of melanocytic nevus:
A. Tan to brown, multi-pigmented
B. Small to medium size (usually more than 6 mm across)
1. List three common malignant skin disorders?: 1. Basal cell Carcinoma
2. Squamous cell Carcinoma
3. Malignant Melanoma
2. The following skin conditions are classified as skin conditions?
-Urticaria
-Dermatitis (Acute and Chronic)
-Psoriasis
-Lichen Planus
-Bullous pemphigoid
-Dermatitis Herpetiformis: Inflammatory
3. are premalignant cutaneous lesions that may pro forms of carcinoma, andgress to
are a common skin condition that develo sun-exposed skin of individuals with cumulative ps in
exposure: Actinic (may present with irregular, red, scaly papules or plaques on sun-expo of the body)
keratosi
4. Actinic keratosis may progress to what type of carcinoma?: SCC s
5. List the five layers of the epidermis from deep to superficial?: 1. stratum basale. sed
2. stratum spinosum.
3. stratum granulosum.
4. stratum lucidum.
5. stratum corneum
6. List the two zones of the dermis from deep to superficial?: 1. The reticular dermis
2. The papillary dermis
7. The dermis is a tough but elastic support structure that houses nerves, blood vessels, lymphatics, and
cutaneous appendages such as?: 1. piloseba- ceous units (hair follicle, hair shaft and sebaceous gland)
2. eccrine
3. apocrine sweat glands
8. The is an important layer and plays a role in shock absorption, energy storage, and
maintenance of body heat: Subcutaneous/hypodermis - fat
9. T or F, please explain your answer:
The epidermis varies in thickness throughout the body depending mainly on frictional forces and is thinnest on th
palms of the hands and soles of the feet, and thickest in the face (eyelids) and genitalia.: False; thickest on hands +
soles, thinnest on eyelids, genitalia
10.Melanocytes are dendritic, pigment-producing cells located in the
layer of the epidermis where they manufacture melanin pigment: Basal
, Dermatopathology (Jani)
11.Langerhans cells are dendritic cells derived from the bone marrow in
the layer of the epidermis, with an immunologic function: stratum spinosum
12.T/F: Langerhans cells are identical to tissue macrophages and present antigens to lymphocytes.: True!
13.T/F: The basal cells or "stem cells" of the epidermis are undifferentiated, proliferating cells that migrate
upwards through all the five layers in a process known as keratinization which takes about 30 days for the cells to
migrate from the basal layer to cross the stratum corneum where they are finally shed.: T
14.T/F: The dermis is thicker (averages 1 to 4 mm) than the epidermis which is about as thin as piece of paper,
it is very thick on the back (almost 1 cm); it is very thin on the eyelid.: True
15.Where are Meissner's corpuscles located?: Papillary dermis
16. cells are needed for production of keratin protein, and are major sites for the
biosynthesis of soluble molecules (cytokines)
E. Specialized dermal cells (dendrocytes) are probably engineered for antigen presentation as well as for
production of molecules (e.g., factor XIIIa) capable of coordinating the assembly of macromolecular complexes
important in the early stages of healing of wounds affecting the deeper cutaneous layers.: - Squamous epithelial
17. are responsible for the production of a brown pigment (melanin) that represents an
important endogenous screen against harmful ultraviolet (UV) rays in sunlight.: Melanocytes
18. cells are epidermal dendritic cells that take up and process antigens and communicate
critical information to lymphoid cells.: Langerhans
19. cells that reside within the basal cell layer, may serve as mechanoreceptors or may
provide neuroendocrine function: Merkel
20. are probably engineered for antigen presentation as well as for production of molecules
(e.g., factor XIIIa) capable of coordinating the assembly of macromolecular complexes important in the early
stages of
healing of wounds affecting the deeper cutaneous layers.: Specialized dermal cells (dendrocytes)
21.Pigemented nevus or mole is a congenital or acquired neoplasm of what cells?: Melanocytes
22.Which of the following is a clinical feature of melanocytic nevus:
A. Tan to brown, multi-pigmented
B. Small to medium size (usually more than 6 mm across)
