Nurs 5334 Advance
Pharm Module 6 part 2
with 100% correct
answers 2025 already
graded A+(verified &
updated)
ovary sequence that occurs: - answer (1) several ovarian follicles
ripen; (2) one of the ripe follicles ruptures, causing ovulation; (3)
the ruptured follicle evolves into a corpus luteum; and (4) if
fertilization does not occur, the corpus luteum atrophies.
Uterus sequence that occurs - answer (1) while ovarian follicles
ripen, the endometrium prepares for nidation (implantation of a
fertilized ovum) by increasing in thickness and vascularity; (2) after
ovulation, the uterus continues its preparation by increasing
secretory activity; and (3) if implantation fails to occur, the
thickened endometrium breaks down, causing menstruation, and
the cycle begins again
Estrogens - answer support the development and maintenance of
the female reproductive tract and secondary sex characteristics.
These hormones are required for the growth and maturation of the
uterus, vagina, fallopian tubes, and breasts. In addition, estrogens
direct pigmentation of the nipples and genitalia.
,Estrogens on follicular phase of menstrual cycle - answer have a
profound influence on physiologic processes related to
reproduction.
promote (1) ductal growth in the breast, (2) thickening and
cornification of the vaginal epithelium, (3) proliferation of the
uterine epithelium, and (4) copious secretion of thickened mucus
from endocervical glands
increase vaginal acidity
decline in levels can bring on menstruation
Estrogen Therapeutic uses - answer include menopausal hormone
therapy (HT); female hypgonadism; acne (oral contraceptives);
cancer palliation; gender affirmation therapy for transgender
women. AEs include endometrial hyperplasia, endometrial
cancer ;breast cancer; CV thromboembolic events/ gallbladder
disease, jaundice, headache; nausea, fluid retention, and chloasma.
Estrogen contraindications - answer should not be taken by patients
with a history of deep vein thrombosis (DVT), pulmonary embolus,
or conditions such as stroke or myocardial infarction (MI) that
occurred secondary to a thromboembolic event.They should not be
prescribed to women who are pregnant or who have vaginal
bleeding without a known cause. Patients with a history of liver
disease, estrogen-dependent tumors, or breast cancer (except when
indicated for management) also should not take estrogens.
Trandermal estradiol - answer emulsion (Estrasorb); spray
(Evamist); Gels (EstroGel, Elestrin, Divigel); Patches (Alora, Climara,
Estraderm, monostar, vivelle-dot, and Oesclim
emulsion (Estrasorb) - answer is applied once daily to the top of
both thighs and the back of both calves
instruct the patient to apply in the morning
evamist - answer The spray is applied once daily to the forearm.
, instruct patient to apply 1, 2, or 3 sprays once daily and then let dry
for and least 2 min before dressing and 30 min before washing
(Divigel) - answer The gel is applied once daily to one arm, from the
shoulder to the wrist or to the thigh
apply once after showering
Alora, Climara, Estraderm, monostar, vivelle-dot, and Oesclim -
answer The patches are applied to the skin of the trunk (but not the
breasts). Rates of estrogen absorption with transdermal
formulations range from 14 to 60 µg/24 hours, depending on the
product used.
if the patch falls off reapply the same or place a new patch
rotate application sites
transdermal formulations have four advantages: - answer The total
dose of estrogen is greatly reduced (liver is bypassed); less nausea
and vomiting; blood levels of estrogen fluctuate less; there is a
lower risk for DVT, PE, and stroke
intravaginal inserts (Imvexxy, Vagifem, Yuvafem) - answer used for
local effects, primary treatment of vulval and vaginal atrophy
associated from with menopause.
consist of one insert for 2 weeks.
Intravaginal creams (Estrace Vaginal, Premarin Vaginal - answer
instruct the patient to apple estrogen cream high into the vagina,
usually at bedtime
vaginal rings - answer (Estring) are used only for local effects,
primarily treatment of vulval and vaginal atrophy associated with
menopause.
Pharm Module 6 part 2
with 100% correct
answers 2025 already
graded A+(verified &
updated)
ovary sequence that occurs: - answer (1) several ovarian follicles
ripen; (2) one of the ripe follicles ruptures, causing ovulation; (3)
the ruptured follicle evolves into a corpus luteum; and (4) if
fertilization does not occur, the corpus luteum atrophies.
Uterus sequence that occurs - answer (1) while ovarian follicles
ripen, the endometrium prepares for nidation (implantation of a
fertilized ovum) by increasing in thickness and vascularity; (2) after
ovulation, the uterus continues its preparation by increasing
secretory activity; and (3) if implantation fails to occur, the
thickened endometrium breaks down, causing menstruation, and
the cycle begins again
Estrogens - answer support the development and maintenance of
the female reproductive tract and secondary sex characteristics.
These hormones are required for the growth and maturation of the
uterus, vagina, fallopian tubes, and breasts. In addition, estrogens
direct pigmentation of the nipples and genitalia.
,Estrogens on follicular phase of menstrual cycle - answer have a
profound influence on physiologic processes related to
reproduction.
promote (1) ductal growth in the breast, (2) thickening and
cornification of the vaginal epithelium, (3) proliferation of the
uterine epithelium, and (4) copious secretion of thickened mucus
from endocervical glands
increase vaginal acidity
decline in levels can bring on menstruation
Estrogen Therapeutic uses - answer include menopausal hormone
therapy (HT); female hypgonadism; acne (oral contraceptives);
cancer palliation; gender affirmation therapy for transgender
women. AEs include endometrial hyperplasia, endometrial
cancer ;breast cancer; CV thromboembolic events/ gallbladder
disease, jaundice, headache; nausea, fluid retention, and chloasma.
Estrogen contraindications - answer should not be taken by patients
with a history of deep vein thrombosis (DVT), pulmonary embolus,
or conditions such as stroke or myocardial infarction (MI) that
occurred secondary to a thromboembolic event.They should not be
prescribed to women who are pregnant or who have vaginal
bleeding without a known cause. Patients with a history of liver
disease, estrogen-dependent tumors, or breast cancer (except when
indicated for management) also should not take estrogens.
Trandermal estradiol - answer emulsion (Estrasorb); spray
(Evamist); Gels (EstroGel, Elestrin, Divigel); Patches (Alora, Climara,
Estraderm, monostar, vivelle-dot, and Oesclim
emulsion (Estrasorb) - answer is applied once daily to the top of
both thighs and the back of both calves
instruct the patient to apply in the morning
evamist - answer The spray is applied once daily to the forearm.
, instruct patient to apply 1, 2, or 3 sprays once daily and then let dry
for and least 2 min before dressing and 30 min before washing
(Divigel) - answer The gel is applied once daily to one arm, from the
shoulder to the wrist or to the thigh
apply once after showering
Alora, Climara, Estraderm, monostar, vivelle-dot, and Oesclim -
answer The patches are applied to the skin of the trunk (but not the
breasts). Rates of estrogen absorption with transdermal
formulations range from 14 to 60 µg/24 hours, depending on the
product used.
if the patch falls off reapply the same or place a new patch
rotate application sites
transdermal formulations have four advantages: - answer The total
dose of estrogen is greatly reduced (liver is bypassed); less nausea
and vomiting; blood levels of estrogen fluctuate less; there is a
lower risk for DVT, PE, and stroke
intravaginal inserts (Imvexxy, Vagifem, Yuvafem) - answer used for
local effects, primary treatment of vulval and vaginal atrophy
associated from with menopause.
consist of one insert for 2 weeks.
Intravaginal creams (Estrace Vaginal, Premarin Vaginal - answer
instruct the patient to apple estrogen cream high into the vagina,
usually at bedtime
vaginal rings - answer (Estring) are used only for local effects,
primarily treatment of vulval and vaginal atrophy associated with
menopause.
