STUDENTS SUCCESS
Revision Examination Tests
“Come all for this Greatness”
... 100% Correct Ans ...
NR 546 EXAM TESTS 2024-2025 COMPLETE
QUESTIONS AND CORRECT DETAILED ANSWERS
Prefrontal Cortex Symptoms of MDD
Ans: Concentration
Mental Fatigue
Mood
Quiz PFC & Amygdala Symptoms of MDD
Ans: Guilt
Suicidality
Worthlessness
Quiz Striatum Symptoms of MDD
Ans: Physical fatigue
Quiz Nucleus Accumbens Symptoms of MDD
Ans: Pleasure interests
Quiz Hypothalamus Symptoms of MDD
Ans: Sleep
Appetite
Quiz Thalamus & Hypothalamus Symptoms of Mania
Ans: Decreased sleep/arousal
Quiz Striatum Symptoms of Mania
Ans: Motor/agitation
Quiz Prefrontal cortex (PFC) Symptoms of Mania
,Ans: Risk-taking
Talkative/pressured speech
Quiz Nucleus Accumbens & PFC Symptoms of Mania
Ans: Racing thoughts, grandiosity
Quiz PFC & Amygdala Symptoms of Mania
Ans: Mood
Quiz Medication Management
Ans: SSRI-Selective Serotonin Reuptake Inhibitors
*Inhibit 5 HT reuptake
SNRI-Serotonin Norepinephrine Reuptake Inhibitors
*inhibit 5-HT reuptake
*inhibit NE reuptake (increase energy, focus)
*increase DA in prefrontal cortex (increase cognition)
NDRI-Norepinephrine Dopamine Reuptake inhibitors
*inhibit DA reuptake (increase alertness, motivation)
*inhibit NE reuptake (increase energy)
SARI-Serotonin Antagonist Reuptake Inhibitors
Quiz Selective Serotonin Reuptake Inhibitors (SSRIs): Most adverse effects will
subside after 4-5 days once the body adjusts to increased serotonin levels.
Ans: diarrhea
headache
weight gain
sexual side effects
Quiz Serotonin Norepinephrine Reuptake Inhibitors (SNRIs): Medications should not
be abruptly stopped to avoid discontinuation symptoms. NE effects of the medication
may increase anxiety in some clients. Report worsening anxiety to the provider.
Ans: elevated blood pressure
anxiety
insomnia
constipation
Quiz Norepinephrine Dopamine Reuptake Inhibitors (NDRI): Take medication in the
morning. Stop taking medication if seizures occur. Stop taking medication if anxiety
is noted.
Ans: agitation
headache
dry mouth
constipation
,weight loss
Quiz escitalopram (Lexapro) SSRI
Ans: no known drug interactions
best tolerated SSRI
27-32 hour half-life good for forgetful prone clients
least CYP reactions
Substrate for 3A4
Quiz citalopram (Celexa) SSRI
Ans: mild antihistamine effects; Half-Life: 23-45 hours
Weak Inhibitor of 2D6
Quiz fluoxetine (Prozac) SSRI
Ans: longest half-life
Use caution in patients with comorbid anxiety due to risk for activation and panic
attacks
Half-Life: 2-3 days parent, 2 week metabolite
Inhibits 2D6 and 3A4
Quiz paroxetine (Paxil) SSRI
Ans: also treats social anxiety and insomnia
associated with weight gain
will experience withdrawal with missed dose or abrupt stop
Half-Life: 24 hours
Inhibits 2D6
Quiz fluvoxamine (Luvox) SSRI
Ans: treats anxious depression smokers require an increased dose
Half-Life: 9-28 hours
Inhibits 3A4, 2C9, 1A2
Quiz sertraline (Zoloft) SSRI
Ans: also treats social anxiety and hypersomnolence
Half-Life: 22-36 hour parent; 62-104 hour metabolite
Inhibits 2D6 and 3A4 weakly at low doses
Quiz venlafaxine (Effexor)
Ans: treats both depression and anxiety disorders, ensure trial of higher dose before
switching to a different medication
Half-life: Parent drug 3-7 hour; metabolite has 9-13 hour
Quiz duloxetine (Cymbalta) SNRI
, Ans: effective for atypical pain at higher doses; appropriate for clients who present
with somatic symptoms of depression; effective for atypical pain, such as
fibromyalgia and diabetic neuropathy
Half-Life: 12 hours
Inhibitor of 2D6
Quiz bupropion (Wellbutrin)
Ans: NDRI may improve energy, alertness, and motivation; not first-line treatment
for anxiety; contraindicated in clients with a history of seizures
Avoid in patients with comorbid anxiety
Half-Life: Parent 10-14 hours; Metabolite 20-27 hours
Inhibits 2D6
Quiz Serotonin Antagonist and Reuptake Inhibitors (SARIs)
Ans: SARIs potently block 5-HT2A and 5HT 2C receptors, which allow more 5-HT to
interact at postsynaptic 5-HT1A sites. Serotonin blockade and reuptake inhibition is
present at higher doses.
Quiz Trazodone
Ans: The most common SARI, also blocks histaminergic and α-adrenergic
receptors.
Half-Life: 3-6 hours
Quiz Serotonin Antagonist and Reuptake Inhibitors (SARIs)
Ans: Common Adverse Effects
· sedation
· drowsiness
· blurred vision
· constipation
· dry mouth
Serious Adverse Effect
priapism
Quiz Serotonin norepinephrine receptor agonist, alpha2 receptor agonist
Ans: Mirtazapine
Quiz Serotonin multimodal (SMM)/serotonin partial agonist reuptake inhibitor
(SPARI)
Ans: Vilazodone (Viibryd)
· Inhibits serotonin reuptake with partial 5HT1A agonism
Appropriate for depression/comorbid anxiety, its action is similar to a combination of
SSRI and buspirone
Revision Examination Tests
“Come all for this Greatness”
... 100% Correct Ans ...
NR 546 EXAM TESTS 2024-2025 COMPLETE
QUESTIONS AND CORRECT DETAILED ANSWERS
Prefrontal Cortex Symptoms of MDD
Ans: Concentration
Mental Fatigue
Mood
Quiz PFC & Amygdala Symptoms of MDD
Ans: Guilt
Suicidality
Worthlessness
Quiz Striatum Symptoms of MDD
Ans: Physical fatigue
Quiz Nucleus Accumbens Symptoms of MDD
Ans: Pleasure interests
Quiz Hypothalamus Symptoms of MDD
Ans: Sleep
Appetite
Quiz Thalamus & Hypothalamus Symptoms of Mania
Ans: Decreased sleep/arousal
Quiz Striatum Symptoms of Mania
Ans: Motor/agitation
Quiz Prefrontal cortex (PFC) Symptoms of Mania
,Ans: Risk-taking
Talkative/pressured speech
Quiz Nucleus Accumbens & PFC Symptoms of Mania
Ans: Racing thoughts, grandiosity
Quiz PFC & Amygdala Symptoms of Mania
Ans: Mood
Quiz Medication Management
Ans: SSRI-Selective Serotonin Reuptake Inhibitors
*Inhibit 5 HT reuptake
SNRI-Serotonin Norepinephrine Reuptake Inhibitors
*inhibit 5-HT reuptake
*inhibit NE reuptake (increase energy, focus)
*increase DA in prefrontal cortex (increase cognition)
NDRI-Norepinephrine Dopamine Reuptake inhibitors
*inhibit DA reuptake (increase alertness, motivation)
*inhibit NE reuptake (increase energy)
SARI-Serotonin Antagonist Reuptake Inhibitors
Quiz Selective Serotonin Reuptake Inhibitors (SSRIs): Most adverse effects will
subside after 4-5 days once the body adjusts to increased serotonin levels.
Ans: diarrhea
headache
weight gain
sexual side effects
Quiz Serotonin Norepinephrine Reuptake Inhibitors (SNRIs): Medications should not
be abruptly stopped to avoid discontinuation symptoms. NE effects of the medication
may increase anxiety in some clients. Report worsening anxiety to the provider.
Ans: elevated blood pressure
anxiety
insomnia
constipation
Quiz Norepinephrine Dopamine Reuptake Inhibitors (NDRI): Take medication in the
morning. Stop taking medication if seizures occur. Stop taking medication if anxiety
is noted.
Ans: agitation
headache
dry mouth
constipation
,weight loss
Quiz escitalopram (Lexapro) SSRI
Ans: no known drug interactions
best tolerated SSRI
27-32 hour half-life good for forgetful prone clients
least CYP reactions
Substrate for 3A4
Quiz citalopram (Celexa) SSRI
Ans: mild antihistamine effects; Half-Life: 23-45 hours
Weak Inhibitor of 2D6
Quiz fluoxetine (Prozac) SSRI
Ans: longest half-life
Use caution in patients with comorbid anxiety due to risk for activation and panic
attacks
Half-Life: 2-3 days parent, 2 week metabolite
Inhibits 2D6 and 3A4
Quiz paroxetine (Paxil) SSRI
Ans: also treats social anxiety and insomnia
associated with weight gain
will experience withdrawal with missed dose or abrupt stop
Half-Life: 24 hours
Inhibits 2D6
Quiz fluvoxamine (Luvox) SSRI
Ans: treats anxious depression smokers require an increased dose
Half-Life: 9-28 hours
Inhibits 3A4, 2C9, 1A2
Quiz sertraline (Zoloft) SSRI
Ans: also treats social anxiety and hypersomnolence
Half-Life: 22-36 hour parent; 62-104 hour metabolite
Inhibits 2D6 and 3A4 weakly at low doses
Quiz venlafaxine (Effexor)
Ans: treats both depression and anxiety disorders, ensure trial of higher dose before
switching to a different medication
Half-life: Parent drug 3-7 hour; metabolite has 9-13 hour
Quiz duloxetine (Cymbalta) SNRI
, Ans: effective for atypical pain at higher doses; appropriate for clients who present
with somatic symptoms of depression; effective for atypical pain, such as
fibromyalgia and diabetic neuropathy
Half-Life: 12 hours
Inhibitor of 2D6
Quiz bupropion (Wellbutrin)
Ans: NDRI may improve energy, alertness, and motivation; not first-line treatment
for anxiety; contraindicated in clients with a history of seizures
Avoid in patients with comorbid anxiety
Half-Life: Parent 10-14 hours; Metabolite 20-27 hours
Inhibits 2D6
Quiz Serotonin Antagonist and Reuptake Inhibitors (SARIs)
Ans: SARIs potently block 5-HT2A and 5HT 2C receptors, which allow more 5-HT to
interact at postsynaptic 5-HT1A sites. Serotonin blockade and reuptake inhibition is
present at higher doses.
Quiz Trazodone
Ans: The most common SARI, also blocks histaminergic and α-adrenergic
receptors.
Half-Life: 3-6 hours
Quiz Serotonin Antagonist and Reuptake Inhibitors (SARIs)
Ans: Common Adverse Effects
· sedation
· drowsiness
· blurred vision
· constipation
· dry mouth
Serious Adverse Effect
priapism
Quiz Serotonin norepinephrine receptor agonist, alpha2 receptor agonist
Ans: Mirtazapine
Quiz Serotonin multimodal (SMM)/serotonin partial agonist reuptake inhibitor
(SPARI)
Ans: Vilazodone (Viibryd)
· Inhibits serotonin reuptake with partial 5HT1A agonism
Appropriate for depression/comorbid anxiety, its action is similar to a combination of
SSRI and buspirone
