NUR-641E PHARMACOLOGY CONCEPTS EXAM 2025| 143 QUESTIONS
WITH ACCURATE SOLUTIONS
1. For drug administer by IM route, drug absorption from aqueous solution
is....than form aqueous suspension or non-aqueous solution of drugs.
Less
Greater
Slower
Less complete
2. Explain why lortadine is preferred over other antihistamines in terms of its
side effects and duration of action.
It causes more sedation than other antihistamines.
It has a shorter duration of action than traditional antihistamines.
It does not impair performance and has a longer duration of
action.
It has more anticholinergic side effects than other medications.
3. The concept of bioequivalence refers to:
Demonstrating equivalence of biologic response for one
formulation or product relative to another
Demonstrating equivalence of both the amount of drug absorbed
and the rate of drug absorption into the systemic circulation for
one formulation or product relative to another
Demonstrating equivalence of the amount of drug absorbed into
the systemic circulation for one formulation or product relative to
another
Demonstrating equivalence of the rate of drug absorption into the
systemic circulation for one formulation or product relative to
,another
,4. Patient on isoniazid for latent TB. 5 months after initiation of therapy, the
patient reports signs of hepatotoxicity including jaundice, N/V, and
abdominal pain. LFTs are completed and AST and ALT are 3x the upper
limit
Stop INH and start RMP when LFTs are normal
Continue INH therapy until LFTs are 5x the UNL
Stop INH and do not rechallenge this patient with any other
medications
Continue INH therapy along with rifampin until the LFTs are 1.5 times
the normal value
5. Explain how polypharmacy can lead to decreased alertness and increased
risk of falls in patients. Which side effects contribute to these outcomes?
Increased appetite and hallucinations
Tiredness, decreased alertness, and dizziness
Skin rashes and anxiety
Excitability and weakness
6. What is the term used to describe the process where a medication in the
gastrointestinal tract is metabolized by the liver before it reaches systemic
circulation?
First pass metabolism
Bioavailability
Pharmacodynamics
Drug clearance
7. Identical doses of a drug are given orally and intravenously. We sample
blood at various times, measure blood concentrations of the drug, and
plot the data (shown in the image).
, Further analysis of only these data will allow you to determine which of the
following?
Elimination route (s)
Extent of plasma protein binding
Oral bioavailability
Potency
Therapeutic effectiveness
8. Increased respiratory rate
tachypnea
acidosis
oliguria
9. A patient is prescribed an oral medication that undergoes significant first
pass metabolism. If the patient has liver dysfunction, what might be the
expected outcome regarding the medication's effectiveness?
The medication will be more effective due to increased absorption.
The medication may have reduced effectiveness due to altered
metabolism.
The medication will not be affected as it bypasses the liver.
WITH ACCURATE SOLUTIONS
1. For drug administer by IM route, drug absorption from aqueous solution
is....than form aqueous suspension or non-aqueous solution of drugs.
Less
Greater
Slower
Less complete
2. Explain why lortadine is preferred over other antihistamines in terms of its
side effects and duration of action.
It causes more sedation than other antihistamines.
It has a shorter duration of action than traditional antihistamines.
It does not impair performance and has a longer duration of
action.
It has more anticholinergic side effects than other medications.
3. The concept of bioequivalence refers to:
Demonstrating equivalence of biologic response for one
formulation or product relative to another
Demonstrating equivalence of both the amount of drug absorbed
and the rate of drug absorption into the systemic circulation for
one formulation or product relative to another
Demonstrating equivalence of the amount of drug absorbed into
the systemic circulation for one formulation or product relative to
another
Demonstrating equivalence of the rate of drug absorption into the
systemic circulation for one formulation or product relative to
,another
,4. Patient on isoniazid for latent TB. 5 months after initiation of therapy, the
patient reports signs of hepatotoxicity including jaundice, N/V, and
abdominal pain. LFTs are completed and AST and ALT are 3x the upper
limit
Stop INH and start RMP when LFTs are normal
Continue INH therapy until LFTs are 5x the UNL
Stop INH and do not rechallenge this patient with any other
medications
Continue INH therapy along with rifampin until the LFTs are 1.5 times
the normal value
5. Explain how polypharmacy can lead to decreased alertness and increased
risk of falls in patients. Which side effects contribute to these outcomes?
Increased appetite and hallucinations
Tiredness, decreased alertness, and dizziness
Skin rashes and anxiety
Excitability and weakness
6. What is the term used to describe the process where a medication in the
gastrointestinal tract is metabolized by the liver before it reaches systemic
circulation?
First pass metabolism
Bioavailability
Pharmacodynamics
Drug clearance
7. Identical doses of a drug are given orally and intravenously. We sample
blood at various times, measure blood concentrations of the drug, and
plot the data (shown in the image).
, Further analysis of only these data will allow you to determine which of the
following?
Elimination route (s)
Extent of plasma protein binding
Oral bioavailability
Potency
Therapeutic effectiveness
8. Increased respiratory rate
tachypnea
acidosis
oliguria
9. A patient is prescribed an oral medication that undergoes significant first
pass metabolism. If the patient has liver dysfunction, what might be the
expected outcome regarding the medication's effectiveness?
The medication will be more effective due to increased absorption.
The medication may have reduced effectiveness due to altered
metabolism.
The medication will not be affected as it bypasses the liver.
