j j
Chapterj01:jCellularjBiology......................................................................................................................................... 4
Chapterj02:jGenesjandjGeneticjDiseases ..................................................................................................................... 13
Chapterj03:jEpigeneticsjandjDisease ........................................................................................................................... 23
UjSNjT O .................................................................................................................................................................... 23
Chapterj04:jAlteredjCellularjandjTissuejBiology ......................................................................................................... 27
Huetherj&jMcCance:jUnderstandingjPathophysiology,j6thjEdition ............................................................................ 39
Chapterj06:jInnatejImmunity:jInflammationjandjWoundjHealingjHuetherj&jMcCance:jUnderstandingjPathophysiolog
y,j6thjEdition............................................................................................................................................................... 48
Chapterj07:jAdaptivejImmunity .................................................................................................................................. 60
Chapterj08:jInfectionjandjDefectsjinjMechanismsjofjDefensejHuetherj&jMcCance:jUnderstandingjPathophysiology,j6t
hjEdition ..................................................................................................................................................................... 66
SINGTB.COM ............................................................................................................................................................... 74
Chapterj09:jStressjandjDisease .................................................................................................................................... 76
Chapterj10:jBiology,jClinicaljManifestations,jandjTreatmentjofjCancerjHuetherj&jMcCance:jUnderstandingjPathophy
siology,j6thjEdition ..................................................................................................................................................... 81
Chapterj11:jCancerjEpidemiology .............................................................................................................................. 87
Chapterj12:jCancerjinjChildren ................................................................................................................................... 91
Chapterj13:jStructurejandjFunctionjofjtheNeurologicjSystemjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6t
hjEdition ..................................................................................................................................................................... 94
Chapterj14:jPain,jTemperature,jSleep,jandjSensoryjFunctionjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6t
hjEdition ................................................................................................................................................................... 105
Chapterj15:jAlterationsjinjCognitivejSystems,jCerebraljHemodynamics,jandjMotorjFunction ................................... 116
Chapterj16:jDisordersjofjtheCentraljandjPeripheraljNervousjSystemsjandjtheNeuromuscularjJunction ...................... 126
Chapterj17:jAlterationsjofjNeurologicjFunctionjinjChildrenjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6thj
Edition...................................................................................................................................................................... 138
Chapterj18:jMechanismsjofjHormonaljRegulation .................................................................................................... 147
Chapterj19:jAlterationsjofjHormonaljRegulation ....................................................................................................... 156
Chapterj20:jStructurejandjFunctionjofjthejHematologicjSystemjHuetherj&jMcCance:jUnderstandingjPathophysiology,j
6thjEdition ................................................................................................................................................................ 169
Chapterj21:jAlterationsjofjHematologicjFunction ...................................................................................................... 176
INGTB.COM ............................................................................................................................................................... 177
Chapterj22:jAlterationsjofjHematologicjFunctionjinjChildrenjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6t
hjEdition ................................................................................................................................................................... 192
Chapterj23:jStructurejandjFunctionjofjthejCardiovascularjandjLymphaticjSystemsjHuetherj&jMcCance:jUnderstandingj
Pathophysiology,j6thjEdition .................................................................................................................................... 200
Chapterj24:jAlterationsjofjCardiovascularjFunction .................................................................................................. 210
UjSNjT O .................................................................................................................................................................. 210
SINGTB.COM ............................................................................................................................................................. 223
UjSNjT O .................................................................................................................................................................. 226
UjSNjT O .................................................................................................................................................................. 228
Chapterj25:jAlterationsjofjCardiovascularjFunctionjinjChildrenjHuetherj&jMcCance:jUnderstandingjPathophysiology,j
6thjEdition ................................................................................................................................................................ 229
SjNjTj j O ........................................................................................................................................................................ 232
Chapterj26:jStructurejandjFunctionjofjthejPulmonaryjSystemjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6t
hjEdition ................................................................................................................................................................... 236
Chapterj27:jAlterationsjofjPulmonaryjFunction ......................................................................................................... 245
, Chapterj28:jAlterationsjofjPulmonaryjFunctionjinjChildrenjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6thj
Edition...................................................................................................................................................................... 257
Chapterj29:jStructurejandjFunctionjofjthejRenaljandjUrologicjSystemsjHuetherj&jMcCance:jUnderstandingjPathophysi
ology,j6thjEdition ..................................................................................................................................................... 265
Chapterj30:jAlterationsjofjRenaljandjUrinaryjTractjFunctionjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6t
hjEdition ................................................................................................................................................................... 273
Chapterj31:jAlterationsjofjRenaljandjUrinaryjTractjFunctionjinjChildrenjHuetherj&jMcCance:jUnderstandingjPathophy
siology,j6thjEdition .................................................................................................................................................. 280
Chapterj32:jStructurejandjFunctionjofjthejReproductivejSystemsjHuetherj&jMcCance:jUnderstandingjPathophysiolog
y,j6thjEdition............................................................................................................................................................. 286
Chapterj33:jAlterationsjofjthejFemalejReproductivejSystemjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6thj
Edition...................................................................................................................................................................... 295
Chapterj34:jAlterationsjofjthejMalejReproductivejSystem ......................................................................................... 300
Chapterj35:jStructurejandjFunctionjofjthejDigestivejSystemjHuetherj&jMcCance:jUnderstandingjPathophysiology,j6thj
Edition...................................................................................................................................................................... 305
Chapterj36:jAlterationsjofjDigestivejFunction ........................................................................................................... 312
Chapterj37:jAlterationsjofjDigestivejFunctionjinjChildren ......................................................................................... 325
Chapterj38:jStructurejandjFunctionjofjthejMusculoskeletaljSystemjHuetherj&jMcCance:jUnderstandingjPathophysiolo
gy,j6thjEdition........................................................................................................................................................... 334
UjSNjT O .................................................................................................................................................................. 337
Chapterj39:jAlterationsjofjMusculoskeletaljFunction ................................................................................................ 342
Chapterj40:jAlterationsjofjMusculoskeletaljFunctionjinjChildrenjHuetherj&jMcCance:jUnderstandingjPathophysiolog
y,j6thjEdition............................................................................................................................................................. 352
UjSNjT O .................................................................................................................................................................. 354
Chapterj41:jStructure,jFunction,jandjDisordersjofjthejIntegumentjHuetherj&jMcCance:jUnderstandingjPathophysiolog
y,j6thjEdition............................................................................................................................................................. 357
Chapterj42:jAlterationsjofjthejIntegumentjinjChildren ............................................................................................... 366
, Chapter 01: Cellular Biology
j j j
Huether & McCance: Understanding Pathophysiology, 6th Edition
j j j j j j
MULTIPLEjCHOICE
1. Ajstudentjisjobservingjajcelljunderjthejmicroscope.jItjisjobservedjtojhavejsupercoiledjDNAjwithj
histones.jWhichjofjthejfollowingjwouldjalsojbejobservedjbyjthejstudent?
a. Ajsinglejcircularjchromosome
b. Ajnucleus
c. Free-floatingjnuclearjmaterial
d. Nojorganelles
ANS:j B
Thejcelljdescribedjisjajeukaryoticjcell,jsojitjhasjhistonesjandjajsupercoiledjDNAjwithinjitsjnucleus;j
thus,jthejnucleusjshouldjbejobserved.jAjsinglejcircularjchromosomejcalledjajprokaryotejcontainsjf
ree-floatingjnuclearjmaterialjbutjhasjnojorganelles.
REF:jp.j2
2. Ajnursejisjinstructingjthejstaffjaboutjcellularjfunctions.jWhichjcellularjfunctionjisjthejnursejdescr
ibingjwhenjanjisolatedjcelljabsorbsjoxygenjandjusesjitjtojtransformjnutrientsjtojenergy?
a. Metabolicjabsorption
b. Communication
c. Secretion
d. Respiration
ANS:jD
Thejcell’sjabilityjtojabsorbjoxygenjisjreferredjtojasjrespirationjwhilejitsjcommunicationjabilityjinvolvesj
maintenancejofjajsteadyjdynamicjstate,jmetabolicjabsorptionjprovidesjnutrition,jandjsecretionjallowsjfo
rjthejsynthesizingjofjnewjsubstances.
REF:jp.j2
3. AjeukaryoticjcelljisjundergoingjDNAjreplication.jInjwhichjregionjofjthejcelljwouldjmostjofjthejg
eneticjinformationjbejcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusjCytoplasm
ANS:jC
Thejregionjofjthejcelljthatjcontainsjgeneticjmaterial,jincludingjajlargejamountjofjribonucleicjacid,j
mostjofjthejDNA,jandjDNA-
bindingjproteins,jisjthejnucleolus,jwhichjisjlocatedjwithinjthejcell’sjnucleus.jMitochondriajisjasso
ciatedjwithjcellularjrespiration,jwhilejribosomesjarejinvolvedjwithjproteinjmanufacturing.jCytopl
asmjisjajfluidjfillingjthatjisjajcomponentjofjthejcell.
REF:jp.j2