NAPLEX- SSTI MCGRAW HILL |ANTIBIOTICS AND
INFECTIONS| ACTUAL EXAM 2025 ||88 QUESTIONS
WITH ACCURATE SOLUTIONS
1. Which of the following antibiotics are appropriate if MRSA coverage is
necessary?
Daptomycin
Vancomycin
Vancomycin or Linezolid
Linezolid
2. A patient is receiving vancomycin 2 grams IV Q12H for treatment of MRSA
osteomyelitis. The nurse asks how long to infuse the medication. Which is
the best recommendation to give the nurse regarding the infusion of this
vancomycin dose?
The vancomycin should be infused over a minimum of 2 hours
The vancomycin should be infused over a maximum of 2 hours
The vancomycin should be infused over a minimum of 1 hour
The vancomycin should be infused over a maximum of 1 hour
The vancomycin should be given via a bolus dose
,3. A patient with a history of MRSA infections presents with a skin abscess.
Given the need for effective treatment without renal adjustment, which
antibiotic would be appropriate, and what is its mechanism of action?
Ceftaroline - Inhibits bacterial cell wall synthesis
Vancomycin - Inhibits bacterial protein synthesis
Linezolid - Inhibits bacterial protein synthesis
Daptomycin - Disrupts bacterial cell membrane
,4. Which antibiotic is known to cause elevated creatine phosphokinase (CPK)
levels and muscle aches as side effects?
Cefuroxime
Daptomycin
Linezolid
Vancomycin
5. Explain why it is important to consider the available formulations of
antibiotics like Vibramycin when prescribing for skin and soft tissue
infections.
To ensure patient compliance and ease of administration
To increase the cost of treatment
To limit the types of bacteria that can be treated
To avoid potential drug interactions
6. Explain why Linezolid is considered safe for use in patients with renal
insufficiency compared to other antibiotics mentioned.
A) Linezolid is eliminated through the kidneys.
B) Linezolid is metabolized through oxidation and excreted via
non-renal routes.
C) Linezolid has no side effects.
D) Linezolid is a broad-spectrum antibiotic.
7. BC is a 40-year-old woman who has hypertension and drug allergies to
, penicillin (angioedema, hives) and sulfa drugs (rash), presents to urgent
care with a dry and intensely red lesion about 5cm x 5cm in size, with well-
demarcated and raised borders on her right lower extremity. She describes
having pain and a burning sensation. What is the most appropriate oral
antibiotic for BC's SSTI?
amoxicillin
INFECTIONS| ACTUAL EXAM 2025 ||88 QUESTIONS
WITH ACCURATE SOLUTIONS
1. Which of the following antibiotics are appropriate if MRSA coverage is
necessary?
Daptomycin
Vancomycin
Vancomycin or Linezolid
Linezolid
2. A patient is receiving vancomycin 2 grams IV Q12H for treatment of MRSA
osteomyelitis. The nurse asks how long to infuse the medication. Which is
the best recommendation to give the nurse regarding the infusion of this
vancomycin dose?
The vancomycin should be infused over a minimum of 2 hours
The vancomycin should be infused over a maximum of 2 hours
The vancomycin should be infused over a minimum of 1 hour
The vancomycin should be infused over a maximum of 1 hour
The vancomycin should be given via a bolus dose
,3. A patient with a history of MRSA infections presents with a skin abscess.
Given the need for effective treatment without renal adjustment, which
antibiotic would be appropriate, and what is its mechanism of action?
Ceftaroline - Inhibits bacterial cell wall synthesis
Vancomycin - Inhibits bacterial protein synthesis
Linezolid - Inhibits bacterial protein synthesis
Daptomycin - Disrupts bacterial cell membrane
,4. Which antibiotic is known to cause elevated creatine phosphokinase (CPK)
levels and muscle aches as side effects?
Cefuroxime
Daptomycin
Linezolid
Vancomycin
5. Explain why it is important to consider the available formulations of
antibiotics like Vibramycin when prescribing for skin and soft tissue
infections.
To ensure patient compliance and ease of administration
To increase the cost of treatment
To limit the types of bacteria that can be treated
To avoid potential drug interactions
6. Explain why Linezolid is considered safe for use in patients with renal
insufficiency compared to other antibiotics mentioned.
A) Linezolid is eliminated through the kidneys.
B) Linezolid is metabolized through oxidation and excreted via
non-renal routes.
C) Linezolid has no side effects.
D) Linezolid is a broad-spectrum antibiotic.
7. BC is a 40-year-old woman who has hypertension and drug allergies to
, penicillin (angioedema, hives) and sulfa drugs (rash), presents to urgent
care with a dry and intensely red lesion about 5cm x 5cm in size, with well-
demarcated and raised borders on her right lower extremity. She describes
having pain and a burning sensation. What is the most appropriate oral
antibiotic for BC's SSTI?
amoxicillin
