N351 exam 2 drugs
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1. Which is the only drug in the Mitotic Agent Colchicine
class? (Colcrys)
2. What is the MOA for Colchicine • Inhibits migration of leukocytes into tis-
(Colcrys) sues. • Decreases inflammatory reaction to
urate crystals in tissues
3. Methods of administration for Colchicine • PO
(Colcrys)?
4. Which drugs therapeutic use is for... Colchicine
• Treatment of acute GOUT (Colcrys)
• Prophylaxis of acute GOUT
5. Adverse effects of Colchicine (Colcrys) • GI effects
• Bone marrow depression
6. Which drug is the only drug in the Uriosuric Allopurinol
agent class? (Zyloprim)
7. What is the MOA for Allopurinol (Zyloprim) • Inhibits enzyme that converts purines to
uric acid. Reduces blood levels of uric acid
8. How can you administer Allopurinol (Zylo- • PO
prim)
9. Which drugs therapeutic use is for... Allopurinol (Zyloprim)
• Management of primary and secondary
GOUT
• Acute and chronic tophaceous GOUT
• Malignancies that result in elevated uric
acid levels
10. Adverse effects of Allopurinol (Zyloprim)
, N351 exam 2 drugs
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• CNS effects
• Bone marrow depression
• GI effects
• Hepatotoxicity
11. What interacts with Allopurinol (Zyloprim)? • Warfarin & Aspirin (increase risk of bleed-
ing)
•Alcohol (decreased excretion of uric acid)
12. Which drug is the only drug in the Gam- Baclofen
ma-aminobutyric Acid Derivative class? (Lioresal)
13. What is the MOA for Baclofen (Lioresal)? • Exact mechanism is unknown. Inhibits
reflex transmission at spinal cord
14. In what ways can we administer Baclofen • PO
(Lioresal)? • Intrathecal
15. What are the therapeutic uses for Baclofen • Muscle spasticity/pain
(Lioresal)?
16. What are the adverse effects of Baclofen • CNS depression
(Lioresal)? • Hypotonia
• Hypotension
• Difficulty w/ urination
• Risk for OD and withdraw
17. Which are special nursing considerations • Do not stop taking abruptly (taper off)
for Baclofen (Lioresal)? • Avoid CNS depressants
• Do not take if pregnant or breastfeeding
18. Which drug is the only drug in the class of Dantrolene sodium
Direct Acting Musculoskeletal Relaxants? (Dantrium)
, N351 exam 2 drugs
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19. What is the MOA for Dantrolene sodium • Acts directly on skeletal muscle. Interferes
(Dantrium) with calcium ion release to relax muscle
20. In which ways can we administer Dantro- • PO
lene sodium (Dantrium)? • IV
21. What are the therapeutic uses for Dantro- • Chronic spasticity
lene sodium (Dantrium)? • Malignant hyperthermia
22. What is the adverse effects of Dantrolene •BLACKBOX: hepatotoxicity
sodium (Dantrium)? •CNS depression
• Flushing
• GI upset
23. Special nursing considerations for Dantro- • Liver function test
lene sodium (Dantrium)?
24. What is the only drug in the class of Tricyclic Cyclobenzaprine hydrochloride
Antidepressant Derivative? (Flexeril)
25. What is the MOA for Cyclobenzaprine hy- • Exact mechanism is unknown. Central-
drochloride (Flexeril) ly-acting skeletal muscle relaxant pharma-
cologically related to Tricyclic Antidepres-
sants. •Depresses motor activity
26. In what ways can we administer Cycloben- • PO
zaprine hydrochloride (Flexeril)
27. Which drug is used to treat.... Cyclobenzaprine hydrochloride
• Muscle spasms (short term 2-3 weeks) (Flexeril)
28. What are the adverse effects of Cycloben- •Anticholinergic
zaprine hydrochloride (Flexeril)? • CNS depression
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1. Which is the only drug in the Mitotic Agent Colchicine
class? (Colcrys)
2. What is the MOA for Colchicine • Inhibits migration of leukocytes into tis-
(Colcrys) sues. • Decreases inflammatory reaction to
urate crystals in tissues
3. Methods of administration for Colchicine • PO
(Colcrys)?
4. Which drugs therapeutic use is for... Colchicine
• Treatment of acute GOUT (Colcrys)
• Prophylaxis of acute GOUT
5. Adverse effects of Colchicine (Colcrys) • GI effects
• Bone marrow depression
6. Which drug is the only drug in the Uriosuric Allopurinol
agent class? (Zyloprim)
7. What is the MOA for Allopurinol (Zyloprim) • Inhibits enzyme that converts purines to
uric acid. Reduces blood levels of uric acid
8. How can you administer Allopurinol (Zylo- • PO
prim)
9. Which drugs therapeutic use is for... Allopurinol (Zyloprim)
• Management of primary and secondary
GOUT
• Acute and chronic tophaceous GOUT
• Malignancies that result in elevated uric
acid levels
10. Adverse effects of Allopurinol (Zyloprim)
, N351 exam 2 drugs
Study online at https://quizlet.com/_dw2tvw
• CNS effects
• Bone marrow depression
• GI effects
• Hepatotoxicity
11. What interacts with Allopurinol (Zyloprim)? • Warfarin & Aspirin (increase risk of bleed-
ing)
•Alcohol (decreased excretion of uric acid)
12. Which drug is the only drug in the Gam- Baclofen
ma-aminobutyric Acid Derivative class? (Lioresal)
13. What is the MOA for Baclofen (Lioresal)? • Exact mechanism is unknown. Inhibits
reflex transmission at spinal cord
14. In what ways can we administer Baclofen • PO
(Lioresal)? • Intrathecal
15. What are the therapeutic uses for Baclofen • Muscle spasticity/pain
(Lioresal)?
16. What are the adverse effects of Baclofen • CNS depression
(Lioresal)? • Hypotonia
• Hypotension
• Difficulty w/ urination
• Risk for OD and withdraw
17. Which are special nursing considerations • Do not stop taking abruptly (taper off)
for Baclofen (Lioresal)? • Avoid CNS depressants
• Do not take if pregnant or breastfeeding
18. Which drug is the only drug in the class of Dantrolene sodium
Direct Acting Musculoskeletal Relaxants? (Dantrium)
, N351 exam 2 drugs
Study online at https://quizlet.com/_dw2tvw
19. What is the MOA for Dantrolene sodium • Acts directly on skeletal muscle. Interferes
(Dantrium) with calcium ion release to relax muscle
20. In which ways can we administer Dantro- • PO
lene sodium (Dantrium)? • IV
21. What are the therapeutic uses for Dantro- • Chronic spasticity
lene sodium (Dantrium)? • Malignant hyperthermia
22. What is the adverse effects of Dantrolene •BLACKBOX: hepatotoxicity
sodium (Dantrium)? •CNS depression
• Flushing
• GI upset
23. Special nursing considerations for Dantro- • Liver function test
lene sodium (Dantrium)?
24. What is the only drug in the class of Tricyclic Cyclobenzaprine hydrochloride
Antidepressant Derivative? (Flexeril)
25. What is the MOA for Cyclobenzaprine hy- • Exact mechanism is unknown. Central-
drochloride (Flexeril) ly-acting skeletal muscle relaxant pharma-
cologically related to Tricyclic Antidepres-
sants. •Depresses motor activity
26. In what ways can we administer Cycloben- • PO
zaprine hydrochloride (Flexeril)
27. Which drug is used to treat.... Cyclobenzaprine hydrochloride
• Muscle spasms (short term 2-3 weeks) (Flexeril)
28. What are the adverse effects of Cycloben- •Anticholinergic
zaprine hydrochloride (Flexeril)? • CNS depression
