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Breast: What is presentation, treatment, prognosis for intraductal
papilloma? - correct answer - presents with bleeding/bloody nipple
discharge (most common cause), usually benign, biopsy/resect via major
duct excision
Breast: What are contraindications to BCT (lumpectomy) in stage I breast
cancer (and what specifically is not)? - correct answer - 1) prior irradiation;
2) pos margins;
3) inflammatory;
4) pregnancy (unless 3rd trimester)
Breast: what are the axillary node levels (1-3, and one more category)? -
correct answer - 1 - lateral to pec minor;
2 - beneath pec minor;
3 - medial to pec minor;
Rotter's Nodes - between pec major and pec minor
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Breast: when is SNLB indicated (size, nodes, tumor status, metastatic
risk)>? - correct answer - >1 cm, no positive nodes (obviously), primary
tumor present, low risk of axillary mets,
Breast: what do you do if you can't find radiotracer dye in SNLB? - correct
answer - have to do formal ALND
Breast: what is treatment for DCIS in male/female? - correct answer -
female -- BCT + xrt OR mastectomy; male -- mastectomy
Breast: what is not needed for patient with negative SLNB? - correct
answer - ALND -- just do BCT or mastectomy depending on tumor is fine
Breast: what patient would get only mastectomy/BCT + tamoxifen for 5
years (4 characteristics)? - correct answer - negative SLN, old, ER+, and
tumor <2 cm
Breast: what patient would get mastectomy/BCT + tamoxifen for 5 years
plus chemo (4 characteristics)? - correct answer - negative SLN, young,
ER+, and tumor >1cm
Breast: what are 3 chemo agents used for breast CA typically? - correct
answer - 1) adriamycin; 2) cyclophosphamide; 3) taxol
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Breast: what patient would get mastectomy/BCT + chemo (no tamoxifen)? -
correct answer - negative SLN, ER-
Breast: what is main SE of taxol? - correct answer - taxol - neuropathy
Breast: what is main SE of adriamycin (doxorubacin)? - correct answer -
cardiomyopathy
Breast: what is treatment for inflammatory breast cancer (in order)? -
correct answer - neoadjuvant chemo, then mastectomy (mod radical), then
XRT
Breast: what options are available for breast mass post neoadjuvant
therapy? - correct answer - same as de novo breast cancer -- BCT or
mastectomy -- if tumor shrunk and now amenable to BCT, that's fine, even
if it was big before and needed mastectomy based on size
Breast: LCIS -- who primarily gets this, what is most important
characteristic, what % get cancer, where, and what type? - correct answer -
- pre-menopausal
- NOT premalignant itself
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- 30% lifetime risk
70% ductal CA
Breast: LCIS -- what % have synchronous cancer? - correct answer - 5%
Breast: LCIS -- what is treatment (4 possibility, 2 things not needed ever)? -
correct answer - 1) Need to resect the lesion but do not need neg margins
2) nothing and careful F/U
3) Hormonal therapy
-(pre-meno: tamoxifen; Post-meno: raloxifene)
4) bilateral subcutaneous mastectomy (no ALND)
Breast: What are the benign proliferative breast lesions that have increased
risk of CA? (3)
Tx? - correct answer - - LCIS
- Atypical ductal hyperplasia
- atypical lobular hyperplasia
Tx: resect the lesion w/ (-) margins
Breast: for atypical ductal hyperplasia; atypical lobular hyperplasia; LCIS,
how are these characterized and what treatment should be considered? -
correct answer - benign proliferative dz. Incr risk of CA.
Need to resect - don't need (-) margins