q q q q q q q q q q q q q
• MOLECULARCELL q q
BIOLOGY
• SIXTH EDITION q
• CHAPTER 3 q
• Protein Structure and Function
q q q
© 2008 W. H. Freeman and Company
q q q q q q
, Human signali
q
ng proteinkea
q q
pl
Ribbon diagram
q
,Conformations Str q
Functional classes:
q q
uctural proteins Sc
q q
Structural proteins T
q q
affold protein Tran
q q
ransport proteins Re
q q
sport protein Regul
q q
gulatoryproteins M
q q
atoryprotein enzy
otor proteins
q q
q
mes
Different conformation = different function
q q q q
, Hierarchical structure of proteins
q q q
Proteins are single, unbranched chains of amino acid monomers
q q q q q q q q
There are 20 different amino acids; All amino acids have the same general structur
q q q q q q q q q q q q q
e but the side chain (R group) of each is different
q q q q q q q q q q
A protein’s amino acid sequence determines its three-
q q q q q q q
dimensional structure (conformation) q q
In turn, a protein’s structure determines the function of that protein
q q q q q q q q q q
pK2 H pK1
+ -
H3N C COO
R