SECTION 1: MECHANISMS OF DISEASE 1
COMPLETE TEST BANK _
RUBIN'S PATHOLOGY: CLINICOPATHOLOGIC FOUNDATIONS OF MEDICINE (7TH) SEVENTH EDITION,
UPDATED
BY DAVID S. STRAYER & EMANUEL RUBIN
ALL CHAPTERS 1-34| 3 UNITS| LATEST VERSION UPDATED WITH DETAILED ANSWERS
, SECTION 1: MECHANISMS OF DISEASE 2
SECTION 1: MECHANISMS OF DISEASE ____________________________________________ 4
CHAPTER 1: CELL ADAPTATION, INJURY AND DEATH ______________________________________ 4
CHAPTER 2: INFLAMMATION ________________________________________________________ 14
CHAPTER 3: REPAIR, REGENERATION AND FIBROSIS _____________________________________ 29
CHAPTER 4: IMMUNOPATHOLOGY ___________________________________________________ 47
CHAPTER 5: NEOPLASIA ____________________________________________________________ 55
CHAPTER 6: DEVELOPMENTAL AND GENETIC DISEASES ___________________________________ 63
CHAPTER 7: HEMODYNAMIC DISORDERS ______________________________________________ 71
CHAPTER 8: ENVIRONMENTAL AND NUTRITIONAL PATHOLOGY____________________________ 80
CHAPTER 9: INFECTIOUS AND PARASITIC DISEASES ______________________________________ 85
SECTION 2: PATHOGENESIS OF SYSTEMIC CONDITIONS ______________________________ 91
CHAPTER 10: AGING _______________________________________________________________ 91
CHAPTER 11: SYSTEMIC AUTOIMMUNE DISEASES _______________________________________ 95
CHAPTER 12: SEPSIS ______________________________________________________________ 102
CHAPTER 13: OBESITY AND DIABETES MELLITUS _______________________________________ 111
CHAPTER 14: THE PATHOLOGY OF PREGNANCY ________________________________________ 118
CHAPTER 15: THE AMYLOIDOSES____________________________________________________ 122
SECTION 3: DISEASES OF INDIVIDUAL ORGAN SYSTEMS ____________________________ 126
CHAPTER 16: BLOOD VESSELS ______________________________________________________ 126
CHAPTER 17: THE HEART __________________________________________________________ 138
CHAPTER 18: THE RESPIRATORY SYSTEM _____________________________________________ 152
CHAPTER 19: THE GASTROINTESTINAL TRACT _________________________________________ 165
CHAPTER 20: THE LIVER AND BILIARY SYSTEM _________________________________________ 184
, SECTION 1: MECHANISMS OF DISEASE 3
CHAPTER 21: THE PANCREAS _______________________________________________________ 191
CHAPTER 22: THE KIDNEY _________________________________________________________ 194
CHAPTER 23: THE LOWER URINARY TRACT AND MALE REPRODUCTIVE SYSTEM ______________ 207
CHAPTER 24: THE FEMALE REPRODUCTIVE SYSTEM AND PERITONEUM _____________________ 213
CHAPTER 25: THE BREAST _________________________________________________________ 221
CHAPTER 26: HEMATOPATHOLOGY _________________________________________________ 228
CHAPTER 27: THE ENDOCRINE SYSTEM _______________________________________________ 241
CHAPTER 28: THE SKIN ____________________________________________________________ 254
CHAPTER 29: THE HEAD AND NECK __________________________________________________ 261
CHAPTER 30: BONES, JOINTS AND SOFT TISSUE ________________________________________ 277
CHAPTER 31: SKELETAL MUSCLE AND PERIPHERAL NERVOUS SYSTEM ______________________ 291
CHAPTER 32: THE CENTRAL NERVOUS SYSTEM ________________________________________ 302
CHAPTER 33: THE EYE _____________________________________________________________ 315
CHAPTER 34: FORENSIC PATHOLOGY ________________________________________________ 319
, SECTION 1: MECHANISMS OF DISEASE 4
SECTION 1: MECHANISMS OF DISEASE
CHAPTER 1: CELL ADAPTATION, INJURY AND DEATH
DAVID S. STRAYER: RUBIN'S PATHOLOGY: CLINICOPATHOLOGIC FOUNDATIONS OF MEDICINE
SEVENTH (7TH) EDITION
MULTIPLE CHOICE
1. ISCHEMIA AND OTHER TOXIC INJURIES INCREASE THE ACCUMULATION OF INTRACELLULAR
CALCIUM AS A RESULT OF:
A) RELEASE OF STORED CALCIUM FROM THE MITOCHONDRIA.
B) IMPROVED INTRACELLULAR VOLUME REGULATION.
C) DECREASED INFLUX ACROSS THE CELL MEMBRANE.
D) ATTRACTION OF CALCIUM TO FATTY INFILTRATES.
CORRECT ANS>>A)
EXPLANATION:
ISCHEMIA AND TOXIC INJURIES LEAD TO IMPAIRED CELL FUNCTION, CAUSING THE RELEASE OF
CALCIUM STORED IN THE MITOCHONDRIA AND OTHER ORGANELLES. THIS RESULTS IN AN
INCREASE IN INTRACELLULAR CALCIUM LEVELS, WHICH CAN ACTIVATE ENZYMES THAT DAMAGE
CELL STRUCTURES, CONTRIBUTING TO CELL INJURY.
2. THE PATIENT IS FOUND TO HAVE LIVER DISEASE, RESULTING IN THE REMOVAL OF A LOBE OF HIS
LIVER. ADAPTATION TO THE REDUCED SIZE OF THE LIVER LEADS TO _ OF THE REMAINING LIVER
CELLS.
A) METAPLASIA
B) ORGAN ATROPHY
C) COMPENSATORY HYPERPLASIA
D) PHYSIOLOGIC HYPERTROPHY
COMPLETE TEST BANK _
RUBIN'S PATHOLOGY: CLINICOPATHOLOGIC FOUNDATIONS OF MEDICINE (7TH) SEVENTH EDITION,
UPDATED
BY DAVID S. STRAYER & EMANUEL RUBIN
ALL CHAPTERS 1-34| 3 UNITS| LATEST VERSION UPDATED WITH DETAILED ANSWERS
, SECTION 1: MECHANISMS OF DISEASE 2
SECTION 1: MECHANISMS OF DISEASE ____________________________________________ 4
CHAPTER 1: CELL ADAPTATION, INJURY AND DEATH ______________________________________ 4
CHAPTER 2: INFLAMMATION ________________________________________________________ 14
CHAPTER 3: REPAIR, REGENERATION AND FIBROSIS _____________________________________ 29
CHAPTER 4: IMMUNOPATHOLOGY ___________________________________________________ 47
CHAPTER 5: NEOPLASIA ____________________________________________________________ 55
CHAPTER 6: DEVELOPMENTAL AND GENETIC DISEASES ___________________________________ 63
CHAPTER 7: HEMODYNAMIC DISORDERS ______________________________________________ 71
CHAPTER 8: ENVIRONMENTAL AND NUTRITIONAL PATHOLOGY____________________________ 80
CHAPTER 9: INFECTIOUS AND PARASITIC DISEASES ______________________________________ 85
SECTION 2: PATHOGENESIS OF SYSTEMIC CONDITIONS ______________________________ 91
CHAPTER 10: AGING _______________________________________________________________ 91
CHAPTER 11: SYSTEMIC AUTOIMMUNE DISEASES _______________________________________ 95
CHAPTER 12: SEPSIS ______________________________________________________________ 102
CHAPTER 13: OBESITY AND DIABETES MELLITUS _______________________________________ 111
CHAPTER 14: THE PATHOLOGY OF PREGNANCY ________________________________________ 118
CHAPTER 15: THE AMYLOIDOSES____________________________________________________ 122
SECTION 3: DISEASES OF INDIVIDUAL ORGAN SYSTEMS ____________________________ 126
CHAPTER 16: BLOOD VESSELS ______________________________________________________ 126
CHAPTER 17: THE HEART __________________________________________________________ 138
CHAPTER 18: THE RESPIRATORY SYSTEM _____________________________________________ 152
CHAPTER 19: THE GASTROINTESTINAL TRACT _________________________________________ 165
CHAPTER 20: THE LIVER AND BILIARY SYSTEM _________________________________________ 184
, SECTION 1: MECHANISMS OF DISEASE 3
CHAPTER 21: THE PANCREAS _______________________________________________________ 191
CHAPTER 22: THE KIDNEY _________________________________________________________ 194
CHAPTER 23: THE LOWER URINARY TRACT AND MALE REPRODUCTIVE SYSTEM ______________ 207
CHAPTER 24: THE FEMALE REPRODUCTIVE SYSTEM AND PERITONEUM _____________________ 213
CHAPTER 25: THE BREAST _________________________________________________________ 221
CHAPTER 26: HEMATOPATHOLOGY _________________________________________________ 228
CHAPTER 27: THE ENDOCRINE SYSTEM _______________________________________________ 241
CHAPTER 28: THE SKIN ____________________________________________________________ 254
CHAPTER 29: THE HEAD AND NECK __________________________________________________ 261
CHAPTER 30: BONES, JOINTS AND SOFT TISSUE ________________________________________ 277
CHAPTER 31: SKELETAL MUSCLE AND PERIPHERAL NERVOUS SYSTEM ______________________ 291
CHAPTER 32: THE CENTRAL NERVOUS SYSTEM ________________________________________ 302
CHAPTER 33: THE EYE _____________________________________________________________ 315
CHAPTER 34: FORENSIC PATHOLOGY ________________________________________________ 319
, SECTION 1: MECHANISMS OF DISEASE 4
SECTION 1: MECHANISMS OF DISEASE
CHAPTER 1: CELL ADAPTATION, INJURY AND DEATH
DAVID S. STRAYER: RUBIN'S PATHOLOGY: CLINICOPATHOLOGIC FOUNDATIONS OF MEDICINE
SEVENTH (7TH) EDITION
MULTIPLE CHOICE
1. ISCHEMIA AND OTHER TOXIC INJURIES INCREASE THE ACCUMULATION OF INTRACELLULAR
CALCIUM AS A RESULT OF:
A) RELEASE OF STORED CALCIUM FROM THE MITOCHONDRIA.
B) IMPROVED INTRACELLULAR VOLUME REGULATION.
C) DECREASED INFLUX ACROSS THE CELL MEMBRANE.
D) ATTRACTION OF CALCIUM TO FATTY INFILTRATES.
CORRECT ANS>>A)
EXPLANATION:
ISCHEMIA AND TOXIC INJURIES LEAD TO IMPAIRED CELL FUNCTION, CAUSING THE RELEASE OF
CALCIUM STORED IN THE MITOCHONDRIA AND OTHER ORGANELLES. THIS RESULTS IN AN
INCREASE IN INTRACELLULAR CALCIUM LEVELS, WHICH CAN ACTIVATE ENZYMES THAT DAMAGE
CELL STRUCTURES, CONTRIBUTING TO CELL INJURY.
2. THE PATIENT IS FOUND TO HAVE LIVER DISEASE, RESULTING IN THE REMOVAL OF A LOBE OF HIS
LIVER. ADAPTATION TO THE REDUCED SIZE OF THE LIVER LEADS TO _ OF THE REMAINING LIVER
CELLS.
A) METAPLASIA
B) ORGAN ATROPHY
C) COMPENSATORY HYPERPLASIA
D) PHYSIOLOGIC HYPERTROPHY
