C HAPTER 45: D RUGS U SED TO T REAT
I NFECTIONS
Willihnganz: Clayton’s Basic Pharmacology for Nurses, 19th Edition
MULTIPLE CHOICE
1. A patient is admitted with glomerulonephritis. IV gentamicin therapy is
started after cultures indicate gram -negative bacilli in the blood. the
patient also receives IV furosemide (Lasix). Which organ monitored for
signs and symptoms of toxicit y?
a. Kidneys
b. Pancreas
c. Liver
d. Brain
ANS: A
The results of urinalysis and kidney function tests should be closel y
monitored when a pati ent is on aminogl ycoside therapy. Patients also
receiving cephalosporins, enflurane, methoxyflurane, vancom ycin, and
diuretics, when combined with aminogl ycosides, have a greater potential for
nephrotoxicit y. the pancreas is not vulnerable to damage from
aminogl ycosides. Bone marrow suppression is a result of toxicit y from
treatment with chloramphenicol. Central nervous system toxicities may result
from toxic effects of treatment with aminogl ycosides but are not related to
interactions between the antibioti c and diuretics.
DIF: Cognitive Level: Comprehension REF: p. 729 OBJ: 3
NAT: NCLEX Client Needs Category: Health Promotion and
Maintenance
, TOP: Nursing Process Step: Evaluation CON: Clinical Judgment |
Safet y
2. Which drug is the cornerstone of treatment for prophylaxis and treatment of
tuberculosis (TB)?
a. Amphotericin B (Abelcet)
b. Streptom ycin (Streptom ycin)
c. Isoniazid (Nydrazid)
d. Acyclovir (Zovirax)
ANS: C
Isoniazid has been the mainstay for years in the treatment and prevention of
TB. the mechanism of action of isoniazid is not full y known. Isoniazid
appears to disrupt the Mycobacterium tuberculosis cell wall and inhibit
replication. Amphotericin B is used in the treatment of fungal infections.
Streptom ycin is an aminogl ycoside used to treat bacteria l infections.
Acyclovir is used in the treatment of viral infections associated with herpes
simplex virus.
DIF: Cognitive Level: Comprehension REF: p. 749 OBJ: 4
NAT: NCLEX Client Needs Category: Health Promotion and
Maintenance
TOP: Nursing Process Step: Evaluation CON: Clinical Judgment
3. Which drug is incompatible with heparin?
a. Gentamicin
b. Ampicillin (Unasyn)
c. Ticarcillin (Timentin)
d. Ciprofloxacin (Cipro)
ANS: A
I NFECTIONS
Willihnganz: Clayton’s Basic Pharmacology for Nurses, 19th Edition
MULTIPLE CHOICE
1. A patient is admitted with glomerulonephritis. IV gentamicin therapy is
started after cultures indicate gram -negative bacilli in the blood. the
patient also receives IV furosemide (Lasix). Which organ monitored for
signs and symptoms of toxicit y?
a. Kidneys
b. Pancreas
c. Liver
d. Brain
ANS: A
The results of urinalysis and kidney function tests should be closel y
monitored when a pati ent is on aminogl ycoside therapy. Patients also
receiving cephalosporins, enflurane, methoxyflurane, vancom ycin, and
diuretics, when combined with aminogl ycosides, have a greater potential for
nephrotoxicit y. the pancreas is not vulnerable to damage from
aminogl ycosides. Bone marrow suppression is a result of toxicit y from
treatment with chloramphenicol. Central nervous system toxicities may result
from toxic effects of treatment with aminogl ycosides but are not related to
interactions between the antibioti c and diuretics.
DIF: Cognitive Level: Comprehension REF: p. 729 OBJ: 3
NAT: NCLEX Client Needs Category: Health Promotion and
Maintenance
, TOP: Nursing Process Step: Evaluation CON: Clinical Judgment |
Safet y
2. Which drug is the cornerstone of treatment for prophylaxis and treatment of
tuberculosis (TB)?
a. Amphotericin B (Abelcet)
b. Streptom ycin (Streptom ycin)
c. Isoniazid (Nydrazid)
d. Acyclovir (Zovirax)
ANS: C
Isoniazid has been the mainstay for years in the treatment and prevention of
TB. the mechanism of action of isoniazid is not full y known. Isoniazid
appears to disrupt the Mycobacterium tuberculosis cell wall and inhibit
replication. Amphotericin B is used in the treatment of fungal infections.
Streptom ycin is an aminogl ycoside used to treat bacteria l infections.
Acyclovir is used in the treatment of viral infections associated with herpes
simplex virus.
DIF: Cognitive Level: Comprehension REF: p. 749 OBJ: 4
NAT: NCLEX Client Needs Category: Health Promotion and
Maintenance
TOP: Nursing Process Step: Evaluation CON: Clinical Judgment
3. Which drug is incompatible with heparin?
a. Gentamicin
b. Ampicillin (Unasyn)
c. Ticarcillin (Timentin)
d. Ciprofloxacin (Cipro)
ANS: A
