Nursing 3100 - Unit 10
Coagulation cascade pathways - ANS-intrinsic and extrinsic
What begins the clotting cascade? - ANS-injury releases first factors
Intrinsic pathway of coagulation - ANS-(PTT)
Happens in blood vessels when collagen fibers of the basement membrane are exposed to
blood
Extrinsic pathway of coagulation - ANS-factors released by damaged tissues begin cascade
Hemostasis - ANS-stoppage of bleeding
Balance of Hemostasis is the balance between - ANS-bleeding and clotting
Thromboembolic disorders - ANS-undesirable clot formation
can be venous or arterial
What causes coagulation disorders? - ANS-low platelets
clotting factor deficiencies
Types of coagulation disorders - ANS-Thrombocytopenia
clotting factor deficiencies
hemophilia
Thrombocytopenia - ANS--low platelet count (<150,000)
-results from decreased production or destruction
Clotting factor deficiencies - ANS-prolonged coagulation & excess bleeding
one factor or multiple
Hemophilia - ANS-genetic deficiency in specific clotting factors
=prolonged coagulation time
Lab tests for coagulation deficiencies - ANS-*PT* (prothrombin time)
*aPTT* (activated partial thromboplastin time)
Whole blood clotting time
Liver function
bleeding time
serum clotting factor levels
Coagulation cascade pathways - ANS-intrinsic and extrinsic
What begins the clotting cascade? - ANS-injury releases first factors
Intrinsic pathway of coagulation - ANS-(PTT)
Happens in blood vessels when collagen fibers of the basement membrane are exposed to
blood
Extrinsic pathway of coagulation - ANS-factors released by damaged tissues begin cascade
Hemostasis - ANS-stoppage of bleeding
Balance of Hemostasis is the balance between - ANS-bleeding and clotting
Thromboembolic disorders - ANS-undesirable clot formation
can be venous or arterial
What causes coagulation disorders? - ANS-low platelets
clotting factor deficiencies
Types of coagulation disorders - ANS-Thrombocytopenia
clotting factor deficiencies
hemophilia
Thrombocytopenia - ANS--low platelet count (<150,000)
-results from decreased production or destruction
Clotting factor deficiencies - ANS-prolonged coagulation & excess bleeding
one factor or multiple
Hemophilia - ANS-genetic deficiency in specific clotting factors
=prolonged coagulation time
Lab tests for coagulation deficiencies - ANS-*PT* (prothrombin time)
*aPTT* (activated partial thromboplastin time)
Whole blood clotting time
Liver function
bleeding time
serum clotting factor levels
