1. Types of tissues: epithelial, connective, muscle, nervous
2. Epithelium: - Sheets of cells that are polarized
- Apical and basal regions
3. connective tissue: A body tissue that provides support for the body and
connects all of its parts
4. cell-cell junctions: specialized structures where two cells come together
5. types of junctions: adhesive (adherens), tight, gap
6. adhesive junctions: - anchor cytoskeleton to cell surface
- rely on adhesion proteins to interact with other proteins on neighboring cells
- E-cadherin
7. tight junctions: - leave no space between the plasma membranes of adjacent
cells
- Molecules can only cross the cell layer by passing through the cell
8. gap junction: region where the plasma membranes of cells are aligned and
brought into contact, with small gap between for passage of small molecules
9. extracellular matrix (ECM): structural scaffold that supports the cells
10. types of ECM: bone, cartilage, connective tissue
11. Classes of ECM Molecules: 1. Structural proteins such as collagen (strength)
2. Protein-polysaccharide complexes, proteoglycans*, that provide the
surrounding medium of the matrix
3. Adhesive glycoproteins (laminin)
12. Collagen: A glycoprotein in the extracellular matrix of animal cells that forms
strong fibers, found extensively in connective tissue and bone; the most
abundant protein in the animal kingdom.
13. Proteoglycans: a glycoprotein consisting of a small core protein with many
carbohydrate chains attached, found in the extracellular matrix of animal cells.
14. Glycoproteins: reinforce direct links between the ECM and the plasma
membrane
15. Laminins: An abundant protein in the extracellular matrix that binds to other
ECM components and to integrins in plasma membranes; helps anchor cells in
place. Predominantly found in the basal lamina; many subtypes function in
different tissues.
16. Integrins: - cell surface receptors that bind to laminin
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