TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEdition
Chapter n01:nCellular nBiology
MULTIPLEnCHOICE
1. A n student nisn observingn ancelln undern thenmicroscope.n It n isn observed n ton haven supercoiled n DNA n
withn histones.n Whichn of n then followingn would n alson ben observed n byn then student?
a. An singlen circularn chromosome
b. An nucleus
c. Free-floatingnnuclearn material
d. Non organelles
ANS:n B
Then celln described n isn an eukaryoticn cell,n son it nhasnhistonesn andnansupercoiled n DNA n withinn itsn nucl
eus;n thus,n then nucleusn should n ben observed.n An singlen circularn chromosomen called n an prokaryoten c
ontainsn free-floatingn nuclearn materialn but n hasn non organelles.
REF:n p.n 2
2. A n nursen isn instructingn then staffn about n cellularn functions.n Whichn cellularn functionn isn then nursen d
escribingn whenn ann isolated n celln absorbsn oxygenn and n usesn it n ton transformn nutrientsn ton energy?
a. Metabolicn absorption
b. Communication
c. Secretion
d. Respiration
ANS:n D
Then cell’sn abilityn ton absorbn oxygenn isn referred n ton asnrespirationn whilen itsn communicationn abilityn invol
vesn maintenancen of n an steadyndynamicn state,nmetabolicn absorptionn providesn nutrition,n andnsecretionn a
llowsn forn then synthesizingn of n new n substances.
REF:n p.n 2
3. A n eukaryoticn celln isn undergoingn DNA nreplication.n Innwhichn regionn ofnthen celln would nmost n of n t
hen geneticn informationn ben contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Nucleusn Cytoplasm
ANS:n C
Then regionn of n then celln that ncontainsngeneticn material,n includingn anlargen amount nofnribonucleicn aci
d,n most n of n then DNA,n and n DNA-
bindingn proteins,n isn then nucleolus,n whichn isn located n withinn then cell’sn nucleus.n Mitochondrian isn a
ssociated n withn cellularn respiration,n whilen ribosomesn aren involved n withn proteinn manufacturing.n
Cytoplasmn isn an fluid n fillingn that n isn an component n of n then cell.
REF:n p.n 2
,TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEdition
Chapter n01:nCellular nBiology
4. Whichn of n then followingn cann removen proteinsn attachedntonthen cell’sn bilayern byn dissolvingn then l
ayern itself?
a. Peripheraln membranen proteins
b. Integraln membranen proteins
c. Glycoproteins
d. Celln adhesionn molecules
ANS:n B
Proteinsn directlynattached n tonthenmembranen bilayern cann benremoved n bynthen actionn of n integraln me
mbranen proteinsn that n dissolven then bilayer.n Peripheraln membranen proteinsn residen at n then surfacenw
hilen celln adhesionn moleculesn aren onn then outsiden of n then membrane.n Glycoproteinn marksn cellsn and
n doesn not n float.
REF:n p.n 7
5. Whichn of n then followingn cann bind n ton plasman membranen receptors?
a. Oxygen
b. Ribosomes
c. Amphipathicn lipids
d. Ligands
ANS:n D
Ligandsn aren then onlyn specificn moleculesn that n cann bind n withn receptorsn onn then celln membrane.
REF:n p.n 9
6. A n nursen isn reviewingn an report n fromn anpatient nwithn metastaticn cancer.n Whatnalternationn inn then e
xtracellularn matrixn wouldn s uNp p oRU
r tnS Ie ndG
nN nT
nt h iagnBo.
siC
sn of M
metastaticn cancer?
a. Decreased n fibronectin
b. Increased n collagen
c. Decreased n elastin
d. Increased n glycoproteins
ANS:n A
Onlynan reduced n amount nofn fibronectinn isn foundninn somen typesn ofncancerousn cells,n allowingn themn
ton traveln orn metastasize.
REF:n p.n 10
7. Whichn formn of n celln communicationn isn used n ton relaten ton othern cellsn inn direct n physicaln contact?
a. Celln junction
b. Gapn junction
c. Desmosome
d. Tight n junction
ANS:n A
Celln junctionsn hold n cellsn togethern and n permit n moleculesn ton passn fromn celln ton cell.
Gapn junctionsn allow n forn cellularncommunicationn betweenn cells.n Neithern desmosomesn norntight n juncti
onsn aren associated n withn cellularn communication.
REF:n p.n 11
,TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEdition
Chapter n01:nCellular nBiology
8. Pancreaticn betan cellsn secreten insulin,n whichn inhibitsn secretionn of n glucagonn fromn neighboringn
alphan cells.n Thisn actionn isn ann examplen of n whichn of n then followingn signalingn types?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:n A
Paracrinen signalingn involvesn then releasen of n localn chemicaln mediatorsn that n aren quicklyntakennup,n d
estroyed,n orn immobilized,n asn inn then casen of ninsulinn and n then inhibitionn of nthen secretionn of n glucago
n.n Nonen of n then othern optionsn involven signalingn that n isn associated nwithn anlocaln chemicaln mediatorn
liken insulin.
REF:n p.n 12
9. Inn cellularn metabolism,n eachn enzymen hasn an highn affinityn forn a:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:n B
Eachn enzymen hasn an highn affinitynfornansubstrate,nanspecificn substancenconvertedn tonanproduct n of n t
hen reaction.n Cellularn metabolismn isn not n dependent n onn annattractionn betweennann enzymen andn any
n of n then remainingn options.
REF:n n p.n 16
10. Ann athleten runsn an marathon,n aftern whichn hisn musclesn feeln fatigued nandn unablen toncontract.nThen at
hleten asksn then nursen whynthisnhappened.nThen nurse’sn responsen isn basednonnthenknowledgenthatn the
n problemn isn result n of n an deficiencyn of:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:n C
Whenn ATPn isn deficient,nimpaired n musclen contractionn results.n Nonenof nthenothernoptionsnaren invo
lved n inn musclen contraction.
REF:n p.n 16
11. Whichn phasen of n catabolismn producesn then most n ATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citricnacid n cycle
ANS:n D
Whilen somen ATPn isn produced n duringn then oxidationn and n glycolysisn phases,n most n of n then ATPn is
, TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEditionn
Chapter n01:nCellular nBiology
generated n duringn then citricn acid n cycle.n Digestionn doesn not n producen anyn ATP.
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEdition
Chapter n01:nCellular nBiology
MULTIPLEnCHOICE
1. A n student nisn observingn ancelln undern thenmicroscope.n It n isn observed n ton haven supercoiled n DNA n
withn histones.n Whichn of n then followingn would n alson ben observed n byn then student?
a. An singlen circularn chromosome
b. An nucleus
c. Free-floatingnnuclearn material
d. Non organelles
ANS:n B
Then celln described n isn an eukaryoticn cell,n son it nhasnhistonesn andnansupercoiled n DNA n withinn itsn nucl
eus;n thus,n then nucleusn should n ben observed.n An singlen circularn chromosomen called n an prokaryoten c
ontainsn free-floatingn nuclearn materialn but n hasn non organelles.
REF:n p.n 2
2. A n nursen isn instructingn then staffn about n cellularn functions.n Whichn cellularn functionn isn then nursen d
escribingn whenn ann isolated n celln absorbsn oxygenn and n usesn it n ton transformn nutrientsn ton energy?
a. Metabolicn absorption
b. Communication
c. Secretion
d. Respiration
ANS:n D
Then cell’sn abilityn ton absorbn oxygenn isn referred n ton asnrespirationn whilen itsn communicationn abilityn invol
vesn maintenancen of n an steadyndynamicn state,nmetabolicn absorptionn providesn nutrition,n andnsecretionn a
llowsn forn then synthesizingn of n new n substances.
REF:n p.n 2
3. A n eukaryoticn celln isn undergoingn DNA nreplication.n Innwhichn regionn ofnthen celln would nmost n of n t
hen geneticn informationn ben contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Nucleusn Cytoplasm
ANS:n C
Then regionn of n then celln that ncontainsngeneticn material,n includingn anlargen amount nofnribonucleicn aci
d,n most n of n then DNA,n and n DNA-
bindingn proteins,n isn then nucleolus,n whichn isn located n withinn then cell’sn nucleus.n Mitochondrian isn a
ssociated n withn cellularn respiration,n whilen ribosomesn aren involved n withn proteinn manufacturing.n
Cytoplasmn isn an fluid n fillingn that n isn an component n of n then cell.
REF:n p.n 2
,TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEdition
Chapter n01:nCellular nBiology
4. Whichn of n then followingn cann removen proteinsn attachedntonthen cell’sn bilayern byn dissolvingn then l
ayern itself?
a. Peripheraln membranen proteins
b. Integraln membranen proteins
c. Glycoproteins
d. Celln adhesionn molecules
ANS:n B
Proteinsn directlynattached n tonthenmembranen bilayern cann benremoved n bynthen actionn of n integraln me
mbranen proteinsn that n dissolven then bilayer.n Peripheraln membranen proteinsn residen at n then surfacenw
hilen celln adhesionn moleculesn aren onn then outsiden of n then membrane.n Glycoproteinn marksn cellsn and
n doesn not n float.
REF:n p.n 7
5. Whichn of n then followingn cann bind n ton plasman membranen receptors?
a. Oxygen
b. Ribosomes
c. Amphipathicn lipids
d. Ligands
ANS:n D
Ligandsn aren then onlyn specificn moleculesn that n cann bind n withn receptorsn onn then celln membrane.
REF:n p.n 9
6. A n nursen isn reviewingn an report n fromn anpatient nwithn metastaticn cancer.n Whatnalternationn inn then e
xtracellularn matrixn wouldn s uNp p oRU
r tnS Ie ndG
nN nT
nt h iagnBo.
siC
sn of M
metastaticn cancer?
a. Decreased n fibronectin
b. Increased n collagen
c. Decreased n elastin
d. Increased n glycoproteins
ANS:n A
Onlynan reduced n amount nofn fibronectinn isn foundninn somen typesn ofncancerousn cells,n allowingn themn
ton traveln orn metastasize.
REF:n p.n 10
7. Whichn formn of n celln communicationn isn used n ton relaten ton othern cellsn inn direct n physicaln contact?
a. Celln junction
b. Gapn junction
c. Desmosome
d. Tight n junction
ANS:n A
Celln junctionsn hold n cellsn togethern and n permit n moleculesn ton passn fromn celln ton cell.
Gapn junctionsn allow n forn cellularncommunicationn betweenn cells.n Neithern desmosomesn norntight n juncti
onsn aren associated n withn cellularn communication.
REF:n p.n 11
,TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEdition
Chapter n01:nCellular nBiology
8. Pancreaticn betan cellsn secreten insulin,n whichn inhibitsn secretionn of n glucagonn fromn neighboringn
alphan cells.n Thisn actionn isn ann examplen of n whichn of n then followingn signalingn types?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:n A
Paracrinen signalingn involvesn then releasen of n localn chemicaln mediatorsn that n aren quicklyntakennup,n d
estroyed,n orn immobilized,n asn inn then casen of ninsulinn and n then inhibitionn of nthen secretionn of n glucago
n.n Nonen of n then othern optionsn involven signalingn that n isn associated nwithn anlocaln chemicaln mediatorn
liken insulin.
REF:n p.n 12
9. Inn cellularn metabolism,n eachn enzymen hasn an highn affinityn forn a:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:n B
Eachn enzymen hasn an highn affinitynfornansubstrate,nanspecificn substancenconvertedn tonanproduct n of n t
hen reaction.n Cellularn metabolismn isn not n dependent n onn annattractionn betweennann enzymen andn any
n of n then remainingn options.
REF:n n p.n 16
10. Ann athleten runsn an marathon,n aftern whichn hisn musclesn feeln fatigued nandn unablen toncontract.nThen at
hleten asksn then nursen whynthisnhappened.nThen nurse’sn responsen isn basednonnthenknowledgenthatn the
n problemn isn result n of n an deficiencyn of:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:n C
Whenn ATPn isn deficient,nimpaired n musclen contractionn results.n Nonenof nthenothernoptionsnaren invo
lved n inn musclen contraction.
REF:n p.n 16
11. Whichn phasen of n catabolismn producesn then most n ATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citricnacid n cycle
ANS:n D
Whilen somen ATPn isn produced n duringn then oxidationn and n glycolysisn phases,n most n of n then ATPn is
, TESTnBANK nFOR nUNDERSTANDING nPATHOPHYSIOLOGY
Huether n&nMcCance:nUnderstanding nPathophysiology,n6thnEditionn
Chapter n01:nCellular nBiology
generated n duringn then citricn acid n cycle.n Digestionn doesn not n producen anyn ATP.
