summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Summary
How the Immune System Works
Lauren M. Sompayrac
9781119890683
7th edition 2022
Chapters 1 - 9 (most important exam)
+ 75 common test bank questions and answers
+ 50 core concepts explained briefly and alphabetically
+ 7 weblinks you need to know
+ Specific exam hacks
+ most important visuals included
Ive made most imporant things for the exam green or yellow
, summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Contents
Chapter 1 An Overview............................................................................................5
The innate immune system (second level of defense).................................................................5
The adaptive immune system (third level of defense).................................................................6
Chapter 2 The Innate Immune System.....................................................................10
The professional phagocytes..................................................................................................... 13
Chapter 3 B cells and antibodies.............................................................................17
The B cell receptor..................................................................................................................... 17
How the BCR signals.................................................................................................................. 17
How B cells are activated........................................................................................................... 19
Antibodies classes and their functions....................................................................................... 20
Chapter 4 The Magic of Antigen Presentation..........................................................24
Class I MHC Molecules................................................................................................................ 24
Class II MHC Molecules............................................................................................................... 24
Antigen presentation by class I MHC molecules.........................................................................24
Antigen presentation by class II MHC molecules........................................................................25
Antigen presenting cells............................................................................................................. 25
The logic of class I MHC presentation........................................................................................ 27
The logic of class II MHC presentation....................................................................................... 27
Cross-presentation..................................................................................................................... 29
Non-classical MHC molecules an lipid presentation...................................................................29
MHC proteins and organ transplantations..................................................................................29
Chapter 5 T Cell Activation.....................................................................................29
T cell receptors.......................................................................................................................... 29
Traditional T cells....................................................................................................................... 29
Non-traditional T cells................................................................................................................ 29
How a T cell’s receptors signals................................................................................................. 31
CD4 and CD8 co-receptors......................................................................................................... 31
Co-stimulation............................................................................................................................ 32
A time-lapse photo of helper T cell activation............................................................................ 32
How killer T cells are activated.................................................................................................. 33
Fail-safe activation..................................................................................................................... 33
Chapter 6 T cells at Work.......................................................................................33
Helper T cells as cytokine factories............................................................................................ 33
The dendritic cells as “coach” of the immune system team......................................................33
Th1 Helper T cells...................................................................................................................... 35
Th2 Helper T cells...................................................................................................................... 35
Th17 Helper T cells.................................................................................................................... 36
Th0 Helper T cells...................................................................................................................... 36
, summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Locking in the helper T cell profile............................................................................................. 36
Delayed-type hypersensitivity................................................................................................... 36
How CTLs KILL............................................................................................................................ 36
Chapter 7 Secondary Lymphoid Organs and Lymphocyte Trafficking.........................38
Lymphoid follicles...................................................................................................................... 38
High endothelial venules............................................................................................................ 39
Lymph nodes.............................................................................................................................. 39
Lymph node choreography........................................................................................................ 40
Recirculation through lymph nodes........................................................................................... 40
Peyer’s patches.......................................................................................................................... 42
The spleen................................................................................................................................. 42
The logic of secondary lymphoid organs.................................................................................... 44
Lymphocyte trafficking.............................................................................................................. 44
Why mothers kiss their babies................................................................................................... 45
Chapter 8 Restraining the Immune System.............................................................45
Attenuating the immune response............................................................................................. 45
Deactivating the system............................................................................................................ 45
Life is short................................................................................................................................ 47
Exhaustion................................................................................................................................. 47
Chapter 9 Self Tolerance and MHC Restriction.........................................................48
the thymus................................................................................................................................. 48
MHC restriction.......................................................................................................................... 48
The logic of MHC restriction....................................................................................................... 48
Thymus testing for tolerance of self........................................................................................... 50
Medullary thymic epithelial cells................................................................................................ 50
Thymic dendritic cells................................................................................................................ 50
Graduation................................................................................................................................. 50
The riddle of MHC restriction and tolerance induction...............................................................50
Tolerance by ignoring................................................................................................................ 52
Tolerance induction in secondary lymphoid organs...................................................................52
Peripheral tolerance induction................................................................................................... 54
Tolerance due to activation-induced cell death.........................................................................54
B cell tolerance.......................................................................................................................... 54
Maintenance of B cell tolerance in germinal centers.................................................................54
Positive selection of natural killer cells...................................................................................... 56
75 common test bank questions and answers..........................................................57
50 core concepts explained briefly and alphabetically.............................................60
7 weblinks you need to know.................................................................................62
Specific exam hacks...............................................................................................63
Common Mistakes...................................................................................................................... 64
, summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Key Theories, Models, and Concepts to Master..........................................................................64
What You Absolutely Must Learn................................................................................................ 64
Common Mistakes Students Make............................................................................................. 65
Best Study Practices for Immunology........................................................................................ 65
Summary
How the Immune System Works
Lauren M. Sompayrac
9781119890683
7th edition 2022
Chapters 1 - 9 (most important exam)
+ 75 common test bank questions and answers
+ 50 core concepts explained briefly and alphabetically
+ 7 weblinks you need to know
+ Specific exam hacks
+ most important visuals included
Ive made most imporant things for the exam green or yellow
, summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Contents
Chapter 1 An Overview............................................................................................5
The innate immune system (second level of defense).................................................................5
The adaptive immune system (third level of defense).................................................................6
Chapter 2 The Innate Immune System.....................................................................10
The professional phagocytes..................................................................................................... 13
Chapter 3 B cells and antibodies.............................................................................17
The B cell receptor..................................................................................................................... 17
How the BCR signals.................................................................................................................. 17
How B cells are activated........................................................................................................... 19
Antibodies classes and their functions....................................................................................... 20
Chapter 4 The Magic of Antigen Presentation..........................................................24
Class I MHC Molecules................................................................................................................ 24
Class II MHC Molecules............................................................................................................... 24
Antigen presentation by class I MHC molecules.........................................................................24
Antigen presentation by class II MHC molecules........................................................................25
Antigen presenting cells............................................................................................................. 25
The logic of class I MHC presentation........................................................................................ 27
The logic of class II MHC presentation....................................................................................... 27
Cross-presentation..................................................................................................................... 29
Non-classical MHC molecules an lipid presentation...................................................................29
MHC proteins and organ transplantations..................................................................................29
Chapter 5 T Cell Activation.....................................................................................29
T cell receptors.......................................................................................................................... 29
Traditional T cells....................................................................................................................... 29
Non-traditional T cells................................................................................................................ 29
How a T cell’s receptors signals................................................................................................. 31
CD4 and CD8 co-receptors......................................................................................................... 31
Co-stimulation............................................................................................................................ 32
A time-lapse photo of helper T cell activation............................................................................ 32
How killer T cells are activated.................................................................................................. 33
Fail-safe activation..................................................................................................................... 33
Chapter 6 T cells at Work.......................................................................................33
Helper T cells as cytokine factories............................................................................................ 33
The dendritic cells as “coach” of the immune system team......................................................33
Th1 Helper T cells...................................................................................................................... 35
Th2 Helper T cells...................................................................................................................... 35
Th17 Helper T cells.................................................................................................................... 36
Th0 Helper T cells...................................................................................................................... 36
, summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Locking in the helper T cell profile............................................................................................. 36
Delayed-type hypersensitivity................................................................................................... 36
How CTLs KILL............................................................................................................................ 36
Chapter 7 Secondary Lymphoid Organs and Lymphocyte Trafficking.........................38
Lymphoid follicles...................................................................................................................... 38
High endothelial venules............................................................................................................ 39
Lymph nodes.............................................................................................................................. 39
Lymph node choreography........................................................................................................ 40
Recirculation through lymph nodes........................................................................................... 40
Peyer’s patches.......................................................................................................................... 42
The spleen................................................................................................................................. 42
The logic of secondary lymphoid organs.................................................................................... 44
Lymphocyte trafficking.............................................................................................................. 44
Why mothers kiss their babies................................................................................................... 45
Chapter 8 Restraining the Immune System.............................................................45
Attenuating the immune response............................................................................................. 45
Deactivating the system............................................................................................................ 45
Life is short................................................................................................................................ 47
Exhaustion................................................................................................................................. 47
Chapter 9 Self Tolerance and MHC Restriction.........................................................48
the thymus................................................................................................................................. 48
MHC restriction.......................................................................................................................... 48
The logic of MHC restriction....................................................................................................... 48
Thymus testing for tolerance of self........................................................................................... 50
Medullary thymic epithelial cells................................................................................................ 50
Thymic dendritic cells................................................................................................................ 50
Graduation................................................................................................................................. 50
The riddle of MHC restriction and tolerance induction...............................................................50
Tolerance by ignoring................................................................................................................ 52
Tolerance induction in secondary lymphoid organs...................................................................52
Peripheral tolerance induction................................................................................................... 54
Tolerance due to activation-induced cell death.........................................................................54
B cell tolerance.......................................................................................................................... 54
Maintenance of B cell tolerance in germinal centers.................................................................54
Positive selection of natural killer cells...................................................................................... 56
75 common test bank questions and answers..........................................................57
50 core concepts explained briefly and alphabetically.............................................60
7 weblinks you need to know.................................................................................62
Specific exam hacks...............................................................................................63
Common Mistakes...................................................................................................................... 64
, summary How the Immune System Works Sompayrac 7th edition 2022 9781119890683
Key Theories, Models, and Concepts to Master..........................................................................64
What You Absolutely Must Learn................................................................................................ 64
Common Mistakes Students Make............................................................................................. 65
Best Study Practices for Immunology........................................................................................ 65
