WGU D027 Advanced
Pathopharmacological Foundations
2024/2025 Exam Questions Marking
Scheme New Update | A+ Rated
A 26-year-old female presents to urgent care with complaints of extreme
fatigue, muscle aches, abdominal pain, numbness and tingling in her
extremities, and bloating. She explains that she has been experiencing
gastrointestinal upset after meals and has not had a bowel movement for the
past four days. She reports using over-the-counter, anti-diarrheal products last
week to combat diarrhea. She denies having any chronic diseases. The
assessment findings include a blood pressure of 108/71 mm Hg, pulse of 82
beats per minute, and respirations of 20 breaths per minute. The abdomen is
distended and firm. Bowel sounds are present in all four quadrants. The patient
has a steady gait, though verbally complains of feeling weak and off balance
upon ambulation. Following antibody testing, Celiac disease is suspected.
Which follow-up tissue test, the gold standard for this suspected diagnosis,
should be ordered?
Page 1 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
,A. Endoscopy - 🧠ANSWER ✔✔C. Endoscopy with small intestine biopsy
A 44-year-old woman has recently been diagnosed with advanced metastatic
non-small-cell lung cancer. Genetic testing is ordered to determine if the
patient's tumor has any genomic alterations and to guide treatment decisions. A
few weeks later, the patient's test results come back positive for a genetic
mutation. The APN starts osimertinib (Tagrisso).
Based on this information, what type of genetic mutation does this patient
have?
A. ALK mutation
B. EGFR mutation
C. BRCA mutation
D. MET amplification mutation - 🧠ANSWER ✔✔B. EGFR mutation
A 20-year-old male meets with an advanced professional nurse (APN) to discuss
symptoms that have been slowly progressing over the past several years. He is
mainly concerned because he has been falling frequently. Since childhood, his
gait has consisted of walking on his toes. During middle school, he was able to
Page 2 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
,participate in sports but was unable to participate in high school sports due to
difficulty with running and jumping. Lately, he has noticed it takes longer and is
more difficult to change positions from sitting to standing than it used to in the
past. He has also been waking up with muscle and joint stiffness. The APRN
notes that his family history is not significant for any chronic or genetic diseases.
Which condition is likely to be the cause of these symptoms?
A. Becker muscular dystrophy
B. Myotonic dystrophy
C. Facioscapulohumeral muscular dystrophy (FSHD)
D. Limb-girdle muscular dystrophy - 🧠ANSWER ✔✔A. Becker muscular dystrophy
Which statement should the provider give the patient regarding the
pathophysiology of SLE and its relation to thrombocytopenia?
A. SLE disrupts immune homeostasis and promotes development of self-reactive
antibodies.
B. SLE causes a cross-reaction of antibodies with normal platelet antigens.
C. SLE causes a defect in the number and function of regulatory B cells.
Page 3 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
, D. SLE increases megakaryocyte maturation. - 🧠ANSWER ✔✔A. SLE disrupts
immune homeostasis and promotes development of self-reactive antibodies
A female patient presents to an office to establish care. Her previous primary
care provider told her to follow up regarding an elevated ferritin level. She has
no previous medical history and is currently asymptomatic. She is concerned
about the elevated ferritin and would like to know if she should be worried.
What should the provider do next for this patient?
A. Order a liver function test
B. Order a renal ultrasound
C. Refer her for a bone marrow biopsy
D. Order a thyroid panel - 🧠ANSWER ✔✔A. Order a liver function test
A 75-year-old female presents to the emergency department with an irregular
heart rate of 130.
What can be ascertained about this patient's findings given the limited
information?
Page 4 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
Pathopharmacological Foundations
2024/2025 Exam Questions Marking
Scheme New Update | A+ Rated
A 26-year-old female presents to urgent care with complaints of extreme
fatigue, muscle aches, abdominal pain, numbness and tingling in her
extremities, and bloating. She explains that she has been experiencing
gastrointestinal upset after meals and has not had a bowel movement for the
past four days. She reports using over-the-counter, anti-diarrheal products last
week to combat diarrhea. She denies having any chronic diseases. The
assessment findings include a blood pressure of 108/71 mm Hg, pulse of 82
beats per minute, and respirations of 20 breaths per minute. The abdomen is
distended and firm. Bowel sounds are present in all four quadrants. The patient
has a steady gait, though verbally complains of feeling weak and off balance
upon ambulation. Following antibody testing, Celiac disease is suspected.
Which follow-up tissue test, the gold standard for this suspected diagnosis,
should be ordered?
Page 1 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
,A. Endoscopy - 🧠ANSWER ✔✔C. Endoscopy with small intestine biopsy
A 44-year-old woman has recently been diagnosed with advanced metastatic
non-small-cell lung cancer. Genetic testing is ordered to determine if the
patient's tumor has any genomic alterations and to guide treatment decisions. A
few weeks later, the patient's test results come back positive for a genetic
mutation. The APN starts osimertinib (Tagrisso).
Based on this information, what type of genetic mutation does this patient
have?
A. ALK mutation
B. EGFR mutation
C. BRCA mutation
D. MET amplification mutation - 🧠ANSWER ✔✔B. EGFR mutation
A 20-year-old male meets with an advanced professional nurse (APN) to discuss
symptoms that have been slowly progressing over the past several years. He is
mainly concerned because he has been falling frequently. Since childhood, his
gait has consisted of walking on his toes. During middle school, he was able to
Page 2 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
,participate in sports but was unable to participate in high school sports due to
difficulty with running and jumping. Lately, he has noticed it takes longer and is
more difficult to change positions from sitting to standing than it used to in the
past. He has also been waking up with muscle and joint stiffness. The APRN
notes that his family history is not significant for any chronic or genetic diseases.
Which condition is likely to be the cause of these symptoms?
A. Becker muscular dystrophy
B. Myotonic dystrophy
C. Facioscapulohumeral muscular dystrophy (FSHD)
D. Limb-girdle muscular dystrophy - 🧠ANSWER ✔✔A. Becker muscular dystrophy
Which statement should the provider give the patient regarding the
pathophysiology of SLE and its relation to thrombocytopenia?
A. SLE disrupts immune homeostasis and promotes development of self-reactive
antibodies.
B. SLE causes a cross-reaction of antibodies with normal platelet antigens.
C. SLE causes a defect in the number and function of regulatory B cells.
Page 3 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
, D. SLE increases megakaryocyte maturation. - 🧠ANSWER ✔✔A. SLE disrupts
immune homeostasis and promotes development of self-reactive antibodies
A female patient presents to an office to establish care. Her previous primary
care provider told her to follow up regarding an elevated ferritin level. She has
no previous medical history and is currently asymptomatic. She is concerned
about the elevated ferritin and would like to know if she should be worried.
What should the provider do next for this patient?
A. Order a liver function test
B. Order a renal ultrasound
C. Refer her for a bone marrow biopsy
D. Order a thyroid panel - 🧠ANSWER ✔✔A. Order a liver function test
A 75-year-old female presents to the emergency department with an irregular
heart rate of 130.
What can be ascertained about this patient's findings given the limited
information?
Page 4 of 32
COPYRIGHT©JOSHCLAY 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER:
619652435. TERMS OF USE. PRIVACY STATEMENT. ALL RIGHTS RESERVED
