PCEUT Test Questions with Verified Answers Latest Update 2025 Already Passed
The higher the LogP value, the greater the aqueous solubility of a drug. - Answers False
A true solution is a mixture of two or more components that form a homogenous dispersion at
molecular level. - Answers True
Bases A and B have pKa value 7 and 10, respectively. Therefore, base A is a weaker base than base B. -
Answers True
Bond energy of electrostatic interactions is weaker than that of van der Waals forces. - Answers False
Buffers can be prepared with strong bases and their salts. - Answers False
Since addition of a succinate group can increase hydrogen bonding between drug and water molecules,
the addition of a succinate group to prednisolone will increase its aqueous solubility. - Answers False
The pH value is calculated mathematically as the log of the hydrogen ion (H+) concentration. - Answers
False
The weak acid aspirin (pKa = 3.49) will be most soluble at pH 6 among the following pH values (pH 1.0,
pH 2.0, pH 3.0, pH 4.0, and pH 6.0). - Answers True
The colligative properties of a solution are related to the total number of solute particles in the solution.
- Answers True
Osmolarity of a solution can be measured in the laboratory while the tonicity of the solution cannot be
determined without knowing the membrane permeability of solutes in the solution to cells or tissues. -
Answers True
Among injections, the route of drug administration that gives the most rapid onset of pharmaceutical
effect is intravenous injection. - Answers True
A solution that passes a test for sterility will also pass a pyrogen-free test. - Answers False
Ringer's Injection, USP, is primarily used as an electrolyte replenisher and plasma volume expander. -
Answers True
To prepare an opthalmic solution, which of the requirements listed below should be considered:
Sterility, Buffering, Adding surfactants - Answers Sterility, Buffering
Porcelain mortar and glass pestle are the best tools for reducing a coarse powder into fine particle-sized
powder because porcelain mortar provides a rough surface for the glass pestle. - Answers False
Capsules of size 00 are larger than those of size 1. - Answers True
,Acetaminophen (Tylenol) X gr is equivalent to 650 mg. - Answers True
Sterile Water for injection is never used for continuous infusion because it results in cell lysis. - Answers
True
USP defines sensitivity requirement for a class A Torsion balance is 6 mg. - Answers True
The dissolution rate of a drug is proportional to the surface area of its particles. - Answers True
Dissolution of a drug at molecular level is a prerequisite for absorption of the drug into the systemic
circulation. - Answers True
Drugs A and B have LogP values 4 and -0.5, respectively. Therefore, drug A is likely to possess a greater
membrane permeability than drug B. - Answers True
Colligative properties of a solution depend on chemical properties of solutes in the solution. - Answers
False
Glucose easily dissolves in water because of strong hydrogen bonding between solute and solvent. -
Answers True
The renal excretion of the weak acid aspirin (pKa = 3.49) would be more rapid in acidic urine than in
alkaline urine. - Answers False
Codeine is more soluble in water than in alcohol. - Answers False
Buffers are always mixtures of weak acids and their conjugate bases or weak bases and their conjugate
acids. - Answers True
pH value of a weak acid buffer is only determined by the acidity constant of the acid. - Answers False
Whether a pharmaceutical solution is isotonic depends on osmolarity of the solution and the membrane
permeability of the cells or tissues with which contact is made. - Answers True
Hypotonic solutions such as sterile water can cause cell damage and thus cannot be directly infused via
the intravenous route. - Answers True
Chelating agents can inhibit oxidation because they are easily oxidized. - Answers False
Bacteriostatic Water for Injection, USP, could be used for injection in neonates. - Answers False
Pyrogens are fever-producing organic substances arising from microbial contamination, which may not
be removed from pharmaceutical solutions by sterilization. - Answers True
Rehydration solutions contain sodium, potassium, bicarbonate, and glucose. - Answers True
Components in dispersed systems tend to mix if the cohesive forces are greater than the adhesive
forces. - Answers False
, The higher the HLB value of a surfactant, the more hydrophilic the surfactant. - Answers True
Some surfactants can help dissolve hydrophobic drugs in aqueous solutions as these surfactants readily
form micelles. - Answers True
Phenobarbital 30 mg can be used interchangeably with Phenobarbital 32.5 mg to fill a prescription of
Phenobarbital 0.5 grain. - Answers True
USP defines sensitivity requirement for a class III prescription balance is 120 mg. - Answers False
Intravenous normal saline infusion is commonly used to replace fluid loss. - Answers True
Size 1 capsules will fill 400 mg of drug and lactose. - Answers True
Trituration is the process of reducing the particle size of powders. - Answers True
For 0.02 M CaCl2 solution, its normality is 0.02 N. - Answers False
The strength of various intermolecular interactions is as follows: induced dipole < dipole < hydrogen
bond < ionic interaction. - Answers True
Increase in temperature will always result in increase in solubility of a chemical. - Answers False
Cocoa butter α and β melt at 23 degrees C and 35 degrees C, respectively. Therefore, cocoa butter α has
a higher aqueous solubility than cocoa butter β. - Answers True
Increase in solubility through chemical modification by adding succinates is due to introduction of ionic
interactions between solvent and solute. - Answers True
In a solution containing methanol and water, hydrogen bond can be formed between methanol and
water, and between methanol and methanol. - Answers True
Ionization of a weak acid in a solution reaches 50% when pH of the solution is equal to pKa of the acid. -
Answers True
Buffer is a solution containing either a weak acid and its salt or a weak base and its salt, which is
resistant to changes in pH upon addition of a large quantity of strong acid or strong base. - Answers
False
Colligative properties of a solution only depend on the number of solute particles in the solution. -
Answers True
Osmosis is the passage of solute molecules across a semipermeable membrane which maintains a solute
concentration gradient across itself. - Answers False
In principle, hypotonic solutions can cause shrinkage of red blood vessels. - Answers False
The higher the LogP value, the greater the aqueous solubility of a drug. - Answers False
A true solution is a mixture of two or more components that form a homogenous dispersion at
molecular level. - Answers True
Bases A and B have pKa value 7 and 10, respectively. Therefore, base A is a weaker base than base B. -
Answers True
Bond energy of electrostatic interactions is weaker than that of van der Waals forces. - Answers False
Buffers can be prepared with strong bases and their salts. - Answers False
Since addition of a succinate group can increase hydrogen bonding between drug and water molecules,
the addition of a succinate group to prednisolone will increase its aqueous solubility. - Answers False
The pH value is calculated mathematically as the log of the hydrogen ion (H+) concentration. - Answers
False
The weak acid aspirin (pKa = 3.49) will be most soluble at pH 6 among the following pH values (pH 1.0,
pH 2.0, pH 3.0, pH 4.0, and pH 6.0). - Answers True
The colligative properties of a solution are related to the total number of solute particles in the solution.
- Answers True
Osmolarity of a solution can be measured in the laboratory while the tonicity of the solution cannot be
determined without knowing the membrane permeability of solutes in the solution to cells or tissues. -
Answers True
Among injections, the route of drug administration that gives the most rapid onset of pharmaceutical
effect is intravenous injection. - Answers True
A solution that passes a test for sterility will also pass a pyrogen-free test. - Answers False
Ringer's Injection, USP, is primarily used as an electrolyte replenisher and plasma volume expander. -
Answers True
To prepare an opthalmic solution, which of the requirements listed below should be considered:
Sterility, Buffering, Adding surfactants - Answers Sterility, Buffering
Porcelain mortar and glass pestle are the best tools for reducing a coarse powder into fine particle-sized
powder because porcelain mortar provides a rough surface for the glass pestle. - Answers False
Capsules of size 00 are larger than those of size 1. - Answers True
,Acetaminophen (Tylenol) X gr is equivalent to 650 mg. - Answers True
Sterile Water for injection is never used for continuous infusion because it results in cell lysis. - Answers
True
USP defines sensitivity requirement for a class A Torsion balance is 6 mg. - Answers True
The dissolution rate of a drug is proportional to the surface area of its particles. - Answers True
Dissolution of a drug at molecular level is a prerequisite for absorption of the drug into the systemic
circulation. - Answers True
Drugs A and B have LogP values 4 and -0.5, respectively. Therefore, drug A is likely to possess a greater
membrane permeability than drug B. - Answers True
Colligative properties of a solution depend on chemical properties of solutes in the solution. - Answers
False
Glucose easily dissolves in water because of strong hydrogen bonding between solute and solvent. -
Answers True
The renal excretion of the weak acid aspirin (pKa = 3.49) would be more rapid in acidic urine than in
alkaline urine. - Answers False
Codeine is more soluble in water than in alcohol. - Answers False
Buffers are always mixtures of weak acids and their conjugate bases or weak bases and their conjugate
acids. - Answers True
pH value of a weak acid buffer is only determined by the acidity constant of the acid. - Answers False
Whether a pharmaceutical solution is isotonic depends on osmolarity of the solution and the membrane
permeability of the cells or tissues with which contact is made. - Answers True
Hypotonic solutions such as sterile water can cause cell damage and thus cannot be directly infused via
the intravenous route. - Answers True
Chelating agents can inhibit oxidation because they are easily oxidized. - Answers False
Bacteriostatic Water for Injection, USP, could be used for injection in neonates. - Answers False
Pyrogens are fever-producing organic substances arising from microbial contamination, which may not
be removed from pharmaceutical solutions by sterilization. - Answers True
Rehydration solutions contain sodium, potassium, bicarbonate, and glucose. - Answers True
Components in dispersed systems tend to mix if the cohesive forces are greater than the adhesive
forces. - Answers False
, The higher the HLB value of a surfactant, the more hydrophilic the surfactant. - Answers True
Some surfactants can help dissolve hydrophobic drugs in aqueous solutions as these surfactants readily
form micelles. - Answers True
Phenobarbital 30 mg can be used interchangeably with Phenobarbital 32.5 mg to fill a prescription of
Phenobarbital 0.5 grain. - Answers True
USP defines sensitivity requirement for a class III prescription balance is 120 mg. - Answers False
Intravenous normal saline infusion is commonly used to replace fluid loss. - Answers True
Size 1 capsules will fill 400 mg of drug and lactose. - Answers True
Trituration is the process of reducing the particle size of powders. - Answers True
For 0.02 M CaCl2 solution, its normality is 0.02 N. - Answers False
The strength of various intermolecular interactions is as follows: induced dipole < dipole < hydrogen
bond < ionic interaction. - Answers True
Increase in temperature will always result in increase in solubility of a chemical. - Answers False
Cocoa butter α and β melt at 23 degrees C and 35 degrees C, respectively. Therefore, cocoa butter α has
a higher aqueous solubility than cocoa butter β. - Answers True
Increase in solubility through chemical modification by adding succinates is due to introduction of ionic
interactions between solvent and solute. - Answers True
In a solution containing methanol and water, hydrogen bond can be formed between methanol and
water, and between methanol and methanol. - Answers True
Ionization of a weak acid in a solution reaches 50% when pH of the solution is equal to pKa of the acid. -
Answers True
Buffer is a solution containing either a weak acid and its salt or a weak base and its salt, which is
resistant to changes in pH upon addition of a large quantity of strong acid or strong base. - Answers
False
Colligative properties of a solution only depend on the number of solute particles in the solution. -
Answers True
Osmosis is the passage of solute molecules across a semipermeable membrane which maintains a solute
concentration gradient across itself. - Answers False
In principle, hypotonic solutions can cause shrinkage of red blood vessels. - Answers False
