PED1003 FORMATIVE QUIZ EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++

PED1003 FORMATIVE QUIZ EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ What is a barrier to glomerular filtration but not active tubular secretion? Plasma protein binding When the drug is in the stomach acid, it will pass through the stomach walls best if it is Unionised The equilibrium dissociation constant (Kd) is a measure of a drugs Affinity Drugs that are high plasma protein bound have what type of volume of distribution? Low Agonism at which receptors results in bronchodilation? Beta 2 receptors Local anaesthetics produce their anaesthetic effect by acting on Voltage gated Na+ channels After intravenous administration, the major factor determining the initial plasma concentration of the drug is its Bioavailability What does bioavailability equal when a drug is given by IV? 100% Antagonism of which receptors results in bronchodilation? Muscarinic receptors Which neurotransmitter is synthesised by a vesicular enzyme? Noradrenaline A patient in a malnourished state will have which pharmacokinetic stage affected? Distribution Adverse pharmacokinetic drug interactions Interfere with the metabolism or excretion of a drug An orally administered basic compound with a pKa of 8 will Be predominantly in ionised form in the stomach