PED1003 PHARMACOLOGY LECTURE 23 EXAM
QUESTIONS AND ANSWERS WITH COMPLETE
SOLUTIONS GRADED A++
What is selective toxicity?
ability of drug to kill or inhibit pathogen while damaging host as little as possible
What do invading cells include?
Bacteria, fungi, viruses and parasites
Why has there been a drop in the number of new antibiotics reaching market in the past 10 years?
- Too little profit
- government restrictions
- lack of new biological targets
etc
Who coined the term "magic bullet"?
Paul Ehrlich
What are the 3 modes of actions of antibiotics?
Bactericidal, bacteriostatic and bacteriolytic
What do bactericidal antibiotics do? and what are some examples
, directly kill viable bacteria cells
What do bacteriostatic antibiotics do? and what is an example?
Slow the growth or reproduction of bacteria. the hosts own immune system can then destroy the
pathogens
What do bacteriolytic antibiotics do? and what are some examples?
Lyse all bacteria cells (not just viable cell)
What are the common bacterial targets for antibiotics?
- Cell membrane
- Cell wall
- Protein synthesis
- RNA polymerase
- DNA synthesis
- Folate metabolism
What does penecillin target?
bacterial cell walls
What do sulphonamide antibiotics target?
Folate metabolism in bacteria
What do fluroquinolone antibiotics target?
DNA synthesis
What do Macrolides and tetracycline antibiotics target?
QUESTIONS AND ANSWERS WITH COMPLETE
SOLUTIONS GRADED A++
What is selective toxicity?
ability of drug to kill or inhibit pathogen while damaging host as little as possible
What do invading cells include?
Bacteria, fungi, viruses and parasites
Why has there been a drop in the number of new antibiotics reaching market in the past 10 years?
- Too little profit
- government restrictions
- lack of new biological targets
etc
Who coined the term "magic bullet"?
Paul Ehrlich
What are the 3 modes of actions of antibiotics?
Bactericidal, bacteriostatic and bacteriolytic
What do bactericidal antibiotics do? and what are some examples
, directly kill viable bacteria cells
What do bacteriostatic antibiotics do? and what is an example?
Slow the growth or reproduction of bacteria. the hosts own immune system can then destroy the
pathogens
What do bacteriolytic antibiotics do? and what are some examples?
Lyse all bacteria cells (not just viable cell)
What are the common bacterial targets for antibiotics?
- Cell membrane
- Cell wall
- Protein synthesis
- RNA polymerase
- DNA synthesis
- Folate metabolism
What does penecillin target?
bacterial cell walls
What do sulphonamide antibiotics target?
Folate metabolism in bacteria
What do fluroquinolone antibiotics target?
DNA synthesis
What do Macrolides and tetracycline antibiotics target?
