PED1003 24 ANTIPROTOZOALS EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS GRADED A++
What are protozoal infections?
parasitic diseases caused by organisms formerly classified in the kingdom Protozoa.
What are Leishmania, Acanthamoeba and malaria?
Protozoal infections
What is malaria?
Malaria is a life-threatening disease caused by parasites that are transmitted to people
through the bites of infected mosquitos
How much of the world population is at risk of malaria?
Half
What percentage of deaths from malaria are in africa?
90%
What is malaria caused by?
Plasmodium
What is plasmodium?
protozoan (parasite) that causes malaria and destroys red blood cellsWhat s
Are plasmodium eukaryotic or prokaryotic?
Eukaryotic
What is distributional selectivity?
, Using a drug that is equally toxic to host and parasite. But if we can ensure that parasite
is exposed to a higher concentration of drug than the host cells then it has a therapeutic
benefit.
How can you achieve distributional selectivity?
- Selective accumulation
- Selective distribution into limited compartments colonised by parasite
- Selective administration into limited compartment colonised by parasite
What are the symptoms of malaria?
Fever, pain, convulsions, coma and death
What cell type is particularly important for the life cycle of the plasmodium?
Erythrocytes (RBC)
What is the exo-erythrocytic stage?
A stage in the life cycle of the malaria parasite found in liver cells (hepatocytes).
Exoerythrocytic stage parasites do not cause symptoms.
What is the erythrocytic stage?
where the pathogen infects RBCs, rupture them, and release more merozoites
True or false, plasmodium has lots of different forms?
True
What is the most common plasmodium that causes malaria?
P. falciparum
How can the different forms of malaria differ?
ANSWERS WITH COMPLETE SOLUTIONS GRADED A++
What are protozoal infections?
parasitic diseases caused by organisms formerly classified in the kingdom Protozoa.
What are Leishmania, Acanthamoeba and malaria?
Protozoal infections
What is malaria?
Malaria is a life-threatening disease caused by parasites that are transmitted to people
through the bites of infected mosquitos
How much of the world population is at risk of malaria?
Half
What percentage of deaths from malaria are in africa?
90%
What is malaria caused by?
Plasmodium
What is plasmodium?
protozoan (parasite) that causes malaria and destroys red blood cellsWhat s
Are plasmodium eukaryotic or prokaryotic?
Eukaryotic
What is distributional selectivity?
, Using a drug that is equally toxic to host and parasite. But if we can ensure that parasite
is exposed to a higher concentration of drug than the host cells then it has a therapeutic
benefit.
How can you achieve distributional selectivity?
- Selective accumulation
- Selective distribution into limited compartments colonised by parasite
- Selective administration into limited compartment colonised by parasite
What are the symptoms of malaria?
Fever, pain, convulsions, coma and death
What cell type is particularly important for the life cycle of the plasmodium?
Erythrocytes (RBC)
What is the exo-erythrocytic stage?
A stage in the life cycle of the malaria parasite found in liver cells (hepatocytes).
Exoerythrocytic stage parasites do not cause symptoms.
What is the erythrocytic stage?
where the pathogen infects RBCs, rupture them, and release more merozoites
True or false, plasmodium has lots of different forms?
True
What is the most common plasmodium that causes malaria?
P. falciparum
How can the different forms of malaria differ?
