Pharmacology USF Mod 1 quiz Review Questions With
Complete Solutions
Competition for Protein Binding Sites:
More free drug increases the risk for ________. Correct
Answers Finite (limited) number of plasma proteins
Compete and displace each other -> more free drug Higher risk
for toxicity
More drug may be eliminated
CYP 450 enzymes:
Name a disease state that has altered isoenzyme activity. What is
the name of the altered enzyme? Correct Answers There are
developmental differences in the isoenzymes
Genetic differences in isoenzymes
Some disease states alter isoenzyme activity
CF (cystic fibrosis) have altered CYP2D9 activity
Degree of Drug Binding
What type of drug crosses membranes?
Low plasma proteins (low albumin) will result in more _____
______in circulation Correct Answers Drugs exist in bound
and unbound states.
Travel when bound, cross membranes when unbound
"Highly" protein bound
, Ratio of bound drug usually remains stable
Low plasma proteins (low albumin) will result in more free
drug in circulation
Drug effectiveness
What is tachyphylaxis?
What is Idiosyncratic drug response?
Hypersensitivity reactions Correct Answers tachyphylaxis- is
the continued or repeated exposure to a drug that may lead to a
weakened pharmacological response.
Idiosyncratic drug response- ADR that will cause an immune
response related to genetic predisposition
Drug receptor binding is reversible, ________, and ______.
Correct Answers Drug receptor binding is reverible, selective,
and graded.
- Effects are proportional to the number of occupied receptors
Drug-dose relationship
What is the difference between doses below the dose response
curve and those above the curve? Correct Answers Dose-
response curve: Depicts the relationship between drug dose and
magnitude of effect.
Complete Solutions
Competition for Protein Binding Sites:
More free drug increases the risk for ________. Correct
Answers Finite (limited) number of plasma proteins
Compete and displace each other -> more free drug Higher risk
for toxicity
More drug may be eliminated
CYP 450 enzymes:
Name a disease state that has altered isoenzyme activity. What is
the name of the altered enzyme? Correct Answers There are
developmental differences in the isoenzymes
Genetic differences in isoenzymes
Some disease states alter isoenzyme activity
CF (cystic fibrosis) have altered CYP2D9 activity
Degree of Drug Binding
What type of drug crosses membranes?
Low plasma proteins (low albumin) will result in more _____
______in circulation Correct Answers Drugs exist in bound
and unbound states.
Travel when bound, cross membranes when unbound
"Highly" protein bound
, Ratio of bound drug usually remains stable
Low plasma proteins (low albumin) will result in more free
drug in circulation
Drug effectiveness
What is tachyphylaxis?
What is Idiosyncratic drug response?
Hypersensitivity reactions Correct Answers tachyphylaxis- is
the continued or repeated exposure to a drug that may lead to a
weakened pharmacological response.
Idiosyncratic drug response- ADR that will cause an immune
response related to genetic predisposition
Drug receptor binding is reversible, ________, and ______.
Correct Answers Drug receptor binding is reverible, selective,
and graded.
- Effects are proportional to the number of occupied receptors
Drug-dose relationship
What is the difference between doses below the dose response
curve and those above the curve? Correct Answers Dose-
response curve: Depicts the relationship between drug dose and
magnitude of effect.
