UNDERSTANDING PATHO EXAM SUCCESS: ULTIMATE
A+, QUESTIONS AND ANSWERS BREAKDOWN
A child is born to a couple, one of whom is a carrier for a sex-linked recessive disease. The other
parent has the disease ("having" the disease means the phenotype is seen—ie, S&S). What would be
the chances that the couple has a child with the disease? (Use a Punnett square to figure this out.)
In the question above, what are the chances that a child will be a carrier?
a. 0%
b. 25%
c. 50%
d. 75%
b. 25%
An RN is taking care of a cocaine addict who has just given birth to a baby with a teratogenic defect. A
student nurse asks him what the probable etiology was. The RN shows understanding of genetic
disorders when he says
a. "It's hard to know the exact cause, but it's likely that fetal chromosomal development was impaired
by the mom's intra-pregnancy cocaine ingestion."
b. "The baby inherited a structural chromosomal defect that resulted in a problem called aneuploidy."
c. "The baby inherited a gene that caused a defect called trisomy 21."
d. "Since the little guy was born with the Philadelphia chromosome, he will be a life-long Phillies fan."
a. "It's hard to know the exact cause, but it's likely that fetal chromosomal development was impaired
by the mom's intra-pregnancy cocaine ingestion."
A child with sickle cell anemia presents with pain all over, especially the joints. Which of the following
best links the patho with S&S?
a. Cyst formation in the kidneys leads to blood spillage from the circulation into the
urine, thus causing anemia.
b. A single-gene mutation causes malfunction of genetic coding for clotting properties, leading
to bleeding and ischemic pain of the joints.
c. Chromosomal aberrancy causes malformation of RBCs in the blood supply to the joints and
subsequent pain due to lack of oxygen.
d. A single-gene mutation causes malfunction in RBC O2-carrying capacity, leading to ischemic pain in
the joint tissues.
d. A single-gene mutation causes malfunction in RBC O2-carrying capacity, leading to ischemic pain in
the joint tissues.
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
Mom's genotype is
a. ss
, b. Ss
c. SS
d. none of the above.
a. ss
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
Which is true about the dad?
a. His genotype is ss.
b. He is a carrier of sickle cell.
c. He likely has the typical S&S of sickle cell.
d. All of the above.
b. He is a carrier of sickle cell.
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
What is the percent possibility of this couple's child having a completely normal genotype?
a. 0%
b. 25%
c. 50%
d. 100%
a. 0%
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
What is the percent possibility of this couple's child having sickle cell trait?
a. 0%
b. 25%
c. 50%
d. 75%
c. 50%
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
What is the percent possibility of this couple's child having the disease, sickle cell anemia?
a. 0%
b. 25%
c. 50%
d. 75%
A+, QUESTIONS AND ANSWERS BREAKDOWN
A child is born to a couple, one of whom is a carrier for a sex-linked recessive disease. The other
parent has the disease ("having" the disease means the phenotype is seen—ie, S&S). What would be
the chances that the couple has a child with the disease? (Use a Punnett square to figure this out.)
In the question above, what are the chances that a child will be a carrier?
a. 0%
b. 25%
c. 50%
d. 75%
b. 25%
An RN is taking care of a cocaine addict who has just given birth to a baby with a teratogenic defect. A
student nurse asks him what the probable etiology was. The RN shows understanding of genetic
disorders when he says
a. "It's hard to know the exact cause, but it's likely that fetal chromosomal development was impaired
by the mom's intra-pregnancy cocaine ingestion."
b. "The baby inherited a structural chromosomal defect that resulted in a problem called aneuploidy."
c. "The baby inherited a gene that caused a defect called trisomy 21."
d. "Since the little guy was born with the Philadelphia chromosome, he will be a life-long Phillies fan."
a. "It's hard to know the exact cause, but it's likely that fetal chromosomal development was impaired
by the mom's intra-pregnancy cocaine ingestion."
A child with sickle cell anemia presents with pain all over, especially the joints. Which of the following
best links the patho with S&S?
a. Cyst formation in the kidneys leads to blood spillage from the circulation into the
urine, thus causing anemia.
b. A single-gene mutation causes malfunction of genetic coding for clotting properties, leading
to bleeding and ischemic pain of the joints.
c. Chromosomal aberrancy causes malformation of RBCs in the blood supply to the joints and
subsequent pain due to lack of oxygen.
d. A single-gene mutation causes malfunction in RBC O2-carrying capacity, leading to ischemic pain in
the joint tissues.
d. A single-gene mutation causes malfunction in RBC O2-carrying capacity, leading to ischemic pain in
the joint tissues.
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
Mom's genotype is
a. ss
, b. Ss
c. SS
d. none of the above.
a. ss
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
Which is true about the dad?
a. His genotype is ss.
b. He is a carrier of sickle cell.
c. He likely has the typical S&S of sickle cell.
d. All of the above.
b. He is a carrier of sickle cell.
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
What is the percent possibility of this couple's child having a completely normal genotype?
a. 0%
b. 25%
c. 50%
d. 100%
a. 0%
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
What is the percent possibility of this couple's child having sickle cell trait?
a. 0%
b. 25%
c. 50%
d. 75%
c. 50%
A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has
sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype.
What is the percent possibility of this couple's child having the disease, sickle cell anemia?
a. 0%
b. 25%
c. 50%
d. 75%
