TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k
Chapter 01: Cellular Biology
k k k
MULTIPLEkCHOICE
1. Akstudentkiskobservingkakcellkunderkthekmicroscope.kItkiskobservedktokhaveksupercoiledkDNAk
withkhistones.kWhichkofkthekfollowingkwouldkalsokbekobservedkbykthekstudent?
a. Aksinglekcircularkchromosome
b. Aknucleus
c. Free-floatingknuclearkmaterial
d. Nokorganelles
ANS:k B
Thekcellkdescribedkiskakeukaryotickcell,ksokitkhaskhistoneskandkaksupercoiledkDNAkwithinkitskn
ucleus;kthus,ktheknucleuskshouldkbekobserved.kAksinglekcircularkchromosomekcalledkakprokar
yotekcontainskfree-floatingknuclearkmaterialkbutkhasknokorganelles.
REF:k p.k2
2. Aknursekiskinstructingkthekstaffkaboutkcellularkfunctions.kWhichkcellularkfunctionkisktheknursekd
escribingkwhenkankisolatedkcellkabsorbskoxygenkandkuseskitktoktransformknutrientsktokenergy?
a. Metabolickabsorption
b. Communication
c. Secretion
d. Respiration
ANS:k D
Thekcell’skabilityktokabsorbkoxygenkiskreferredktokaskrespirationkwhilekitskcommunicationkabilityki
nvolveskmaintenancekofkaksteadykdynamickstate,kmetabolickabsorptionkprovidesknutrition,kandkse
cretionkallowskforktheksynthesizingkofknewksubstances.
REF:k p.k2
3. AkeukaryotickcellkiskundergoingkDNAkreplication.kInkwhichkregionkofkthekcellkwouldkmostkofkt
hekgenetickinformationkbekcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleuskCytoplasm
ANS:k C
Thekregionkofkthekcellkthatkcontainskgenetickmaterial,kincludingkaklargekamountkofkribonucleicka
cid,kmostkofkthekDNA,kandkDNA-
bindingkproteins,kisktheknucleolus,kwhichkisklocatedkwithinkthekcell’sknucleus.kMitochondriakisk
associatedkwithkcellularkrespiration,kwhilekribosomeskarekinvolvedkwithkproteinkmanufacturin
g.kCytoplasmkiskakfluidkfillingkthatkiskakcomponentkofkthekcell.
REF:k p.k2
,TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k
Chapter 01: Cellular Biology
k k k
4. Whichkofkthekfollowingkcankremovekproteinskattachedktokthekcell’skbilayerkbykdissolvingkthekl
ayerkitself?
a. Peripheralkmembranekproteins
b. Integralkmembranekproteins
c. Glycoproteins
d. Cellkadhesionkmolecules
ANS:k B
Proteinskdirectlykattachedktokthekmembranekbilayerkcankbekremovedkbykthekactionkofkintegralkme
mbranekproteinskthatkdissolvekthekbilayer.kPeripheralkmembranekproteinskresidekatktheksurfacek
whilekcellkadhesionkmoleculeskarekonkthekoutsidekofkthekmembrane.kGlycoproteinkmarkskcellska
ndkdoesknotk float.
REF:k p.k7
5. Whichkofkthekfollowingkcankbindktokplasmakmembranekreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathicklipids
d. Ligands
ANS:k D
Ligandskarekthekonlykspecifickmoleculeskthatkcankbindkwithkreceptorskonkthekcellkmembrane.
REF:k p.k9
6. Aknursekiskreviewingkakreportkfromkakpatientkwithkmetastatickcancer.kWhatkalternationkinktheke
xtracellularkmatrixkwouldksuN RrtkS
ppoU IkN
kth G
iagnBo.
ekdkT siC
skofM
metastatickcancer?
a. Decreasedkfibronectin
b. Increasedkcollagen
c. Decreasedkelastin
d. Increasedkglycoproteins
ANS:k A
Onlykakreducedkamountkofkfibronectinkiskfoundkinksomektypeskofkcancerouskcells,kallowingkt
hemktoktravelkorkmetastasize.
REF:k p.k10
7. Whichkformkofkcellkcommunicationkiskusedktokrelatektokotherkcellskinkdirectkphysicalkcontact?
a. Cellkjunction
b. Gapkjunction
c. Desmosome
d. Tightkjunction
ANS:k A
Cellkjunctionskholdkcellsktogetherkandkpermitkmoleculesktokpasskfromkcellktokcell.
Gapkjunctionskallowkforkcellularkcommunicationkbetweenkcells.kNeitherkdesmosomesknorktightkj
unctionskarekassociatedkwithkcellularkcommunication.
REF:k p.k11
,TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k
Chapter 01: Cellular Biology
k k k
8. Pancreatickbetakcellsksecretekinsulin,kwhichkinhibitsksecretionkofkglucagonkfromkneighboringka
lphakcells.kThiskactionkiskankexamplekofkwhichkofkthekfollowingksignalingktypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:k A
Paracrineksignalingkinvolveskthekreleasekofklocalkchemicalkmediatorskthatkarekquicklyktakenkup,kd
estroyed,korkimmobilized,kaskinkthekcasekofkinsulinkandkthekinhibitionkofktheksecretionkofkglucago
n.kNonekofkthekotherkoptionskinvolveksignalingkthatkiskassociatedkwithkaklocalkchemicalkmediatork
likekinsulin.
REF:k p.k12
9. Inkcellularkmetabolism,keachkenzymekhaskakhighkaffinitykforka:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:k B
Eachkenzymekhaskakhighkaffinitykforkaksubstrate,kakspecificksubstancekconvertedktokakproductkofkt
hekreaction.kCellularkmetabolismkisknotkdependentkonkankattractionkbetweenkankenzymekandkanyk
ofkthekremainingkoptions.
REF:k p.k16
10. Ankathletekrunskakmarathon,kafterkwhichkhiskmuscleskfeelkfatiguedkandkunablektokcontract.kThekat
hletekasksktheknursekwhykthiskhappened.kTheknurse’skresponsekiskbasedkonkthekknowledgekthatkthe
kproblemkiskresultkofkakdeficiencykof:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:k C
WhenkATPkiskdeficient,kimpairedkmusclekcontractionkresults.kNonekofkthekotherkoptionskareki
nvolvedkinkmusclekcontraction.
REF:k p.k16
11. WhichkphasekofkcatabolismkproduceskthekmostkATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citrickacidkcycle
ANS:k D
WhileksomekATPkiskproducedkduringkthekoxidationkandkglycolysiskphases,kmostkofkthekATPkis
, TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k k
Chapter 01: Cellular Biology
k k k
generatedkduringkthekcitrickacidkcycle.kDigestionkdoesknotkproducekanykATP.
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k
Chapter 01: Cellular Biology
k k k
MULTIPLEkCHOICE
1. Akstudentkiskobservingkakcellkunderkthekmicroscope.kItkiskobservedktokhaveksupercoiledkDNAk
withkhistones.kWhichkofkthekfollowingkwouldkalsokbekobservedkbykthekstudent?
a. Aksinglekcircularkchromosome
b. Aknucleus
c. Free-floatingknuclearkmaterial
d. Nokorganelles
ANS:k B
Thekcellkdescribedkiskakeukaryotickcell,ksokitkhaskhistoneskandkaksupercoiledkDNAkwithinkitskn
ucleus;kthus,ktheknucleuskshouldkbekobserved.kAksinglekcircularkchromosomekcalledkakprokar
yotekcontainskfree-floatingknuclearkmaterialkbutkhasknokorganelles.
REF:k p.k2
2. Aknursekiskinstructingkthekstaffkaboutkcellularkfunctions.kWhichkcellularkfunctionkisktheknursekd
escribingkwhenkankisolatedkcellkabsorbskoxygenkandkuseskitktoktransformknutrientsktokenergy?
a. Metabolickabsorption
b. Communication
c. Secretion
d. Respiration
ANS:k D
Thekcell’skabilityktokabsorbkoxygenkiskreferredktokaskrespirationkwhilekitskcommunicationkabilityki
nvolveskmaintenancekofkaksteadykdynamickstate,kmetabolickabsorptionkprovidesknutrition,kandkse
cretionkallowskforktheksynthesizingkofknewksubstances.
REF:k p.k2
3. AkeukaryotickcellkiskundergoingkDNAkreplication.kInkwhichkregionkofkthekcellkwouldkmostkofkt
hekgenetickinformationkbekcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleuskCytoplasm
ANS:k C
Thekregionkofkthekcellkthatkcontainskgenetickmaterial,kincludingkaklargekamountkofkribonucleicka
cid,kmostkofkthekDNA,kandkDNA-
bindingkproteins,kisktheknucleolus,kwhichkisklocatedkwithinkthekcell’sknucleus.kMitochondriakisk
associatedkwithkcellularkrespiration,kwhilekribosomeskarekinvolvedkwithkproteinkmanufacturin
g.kCytoplasmkiskakfluidkfillingkthatkiskakcomponentkofkthekcell.
REF:k p.k2
,TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k
Chapter 01: Cellular Biology
k k k
4. Whichkofkthekfollowingkcankremovekproteinskattachedktokthekcell’skbilayerkbykdissolvingkthekl
ayerkitself?
a. Peripheralkmembranekproteins
b. Integralkmembranekproteins
c. Glycoproteins
d. Cellkadhesionkmolecules
ANS:k B
Proteinskdirectlykattachedktokthekmembranekbilayerkcankbekremovedkbykthekactionkofkintegralkme
mbranekproteinskthatkdissolvekthekbilayer.kPeripheralkmembranekproteinskresidekatktheksurfacek
whilekcellkadhesionkmoleculeskarekonkthekoutsidekofkthekmembrane.kGlycoproteinkmarkskcellska
ndkdoesknotk float.
REF:k p.k7
5. Whichkofkthekfollowingkcankbindktokplasmakmembranekreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathicklipids
d. Ligands
ANS:k D
Ligandskarekthekonlykspecifickmoleculeskthatkcankbindkwithkreceptorskonkthekcellkmembrane.
REF:k p.k9
6. Aknursekiskreviewingkakreportkfromkakpatientkwithkmetastatickcancer.kWhatkalternationkinktheke
xtracellularkmatrixkwouldksuN RrtkS
ppoU IkN
kth G
iagnBo.
ekdkT siC
skofM
metastatickcancer?
a. Decreasedkfibronectin
b. Increasedkcollagen
c. Decreasedkelastin
d. Increasedkglycoproteins
ANS:k A
Onlykakreducedkamountkofkfibronectinkiskfoundkinksomektypeskofkcancerouskcells,kallowingkt
hemktoktravelkorkmetastasize.
REF:k p.k10
7. Whichkformkofkcellkcommunicationkiskusedktokrelatektokotherkcellskinkdirectkphysicalkcontact?
a. Cellkjunction
b. Gapkjunction
c. Desmosome
d. Tightkjunction
ANS:k A
Cellkjunctionskholdkcellsktogetherkandkpermitkmoleculesktokpasskfromkcellktokcell.
Gapkjunctionskallowkforkcellularkcommunicationkbetweenkcells.kNeitherkdesmosomesknorktightkj
unctionskarekassociatedkwithkcellularkcommunication.
REF:k p.k11
,TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k
Chapter 01: Cellular Biology
k k k
8. Pancreatickbetakcellsksecretekinsulin,kwhichkinhibitsksecretionkofkglucagonkfromkneighboringka
lphakcells.kThiskactionkiskankexamplekofkwhichkofkthekfollowingksignalingktypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:k A
Paracrineksignalingkinvolveskthekreleasekofklocalkchemicalkmediatorskthatkarekquicklyktakenkup,kd
estroyed,korkimmobilized,kaskinkthekcasekofkinsulinkandkthekinhibitionkofktheksecretionkofkglucago
n.kNonekofkthekotherkoptionskinvolveksignalingkthatkiskassociatedkwithkaklocalkchemicalkmediatork
likekinsulin.
REF:k p.k12
9. Inkcellularkmetabolism,keachkenzymekhaskakhighkaffinitykforka:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:k B
Eachkenzymekhaskakhighkaffinitykforkaksubstrate,kakspecificksubstancekconvertedktokakproductkofkt
hekreaction.kCellularkmetabolismkisknotkdependentkonkankattractionkbetweenkankenzymekandkanyk
ofkthekremainingkoptions.
REF:k p.k16
10. Ankathletekrunskakmarathon,kafterkwhichkhiskmuscleskfeelkfatiguedkandkunablektokcontract.kThekat
hletekasksktheknursekwhykthiskhappened.kTheknurse’skresponsekiskbasedkonkthekknowledgekthatkthe
kproblemkiskresultkofkakdeficiencykof:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:k C
WhenkATPkiskdeficient,kimpairedkmusclekcontractionkresults.kNonekofkthekotherkoptionskareki
nvolvedkinkmusclekcontraction.
REF:k p.k16
11. WhichkphasekofkcatabolismkproduceskthekmostkATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citrickacidkcycle
ANS:k D
WhileksomekATPkiskproducedkduringkthekoxidationkandkglycolysiskphases,kmostkofkthekATPkis
, TESTkBANKkFORkUNDERSTANDINGkPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
k k k k k k k
Chapter 01: Cellular Biology
k k k
generatedkduringkthekcitrickacidkcycle.kDigestionkdoesknotkproducekanykATP.
