BIOL4004 WEEK 6 EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Coat-recruitment GTPases
A family of proteins that inserts into the membrane and binds coat proteins and cargo
during COPI-, COPII-, and retromer-coated vesicle formation; includes Sar1
COPI-coated vesicles
Coated vesicles that transport material from the Golgi back to the ER
Dynamin
Forms a spiral around the neck of a clathrin-coated bud, regulates membrane fusion,
vesicle release
Autophagy
"Self eating", when a cell engulfs components of its own cytoplasm for degradation in
lysosomes
ESCRTs
Protein complexes that regulate membrane budding including intralumenal vesicle
formation and cytokinesis
Rab
A family of small GTPases; controls vesicular traffic by recruiting effector proteins that
define membrane identity and function, mediate vesicular docking and fusion
Clathrin-coated vesicles
, Coated vesicles that transport material endocytosed at the plasma membrane and
within endosomal compartments
Cis face of the Golgi
Side of the Golgi stack at which material enters
Golgi reassembly and stacking proteins (GRASPs)
Structural proteins that create a scaffold between adjacent cisternae to form the Golgi
stacks
SNAREs
Mediate vesicle docking and fusion to specific target membranes by winding into stable
4-helix complexes
Lysosomes
Membrane-bound organelle which contains digestive enzymes most active at low pH
Macropinocytosis
"Cell drinking", when a cell non-specifically traps extracellular fluid and material
Phosphoinositides (PIPs)
Variable phosphorylation of the 3', 4', and 5' position of this phosphilipid's sugar head
group recruits different proteins to create functionally distinct membrane domains
ER exit sites
COPII-coated vesicles bud from this specialized region of the ER that is devoid of
ribosomes
Mannose-6-phosphate (M6P)
This modification identifies acid (lysosome) hydrolases, formed by trimming GlcNAc
from N-linked glycosylation
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
Coat-recruitment GTPases
A family of proteins that inserts into the membrane and binds coat proteins and cargo
during COPI-, COPII-, and retromer-coated vesicle formation; includes Sar1
COPI-coated vesicles
Coated vesicles that transport material from the Golgi back to the ER
Dynamin
Forms a spiral around the neck of a clathrin-coated bud, regulates membrane fusion,
vesicle release
Autophagy
"Self eating", when a cell engulfs components of its own cytoplasm for degradation in
lysosomes
ESCRTs
Protein complexes that regulate membrane budding including intralumenal vesicle
formation and cytokinesis
Rab
A family of small GTPases; controls vesicular traffic by recruiting effector proteins that
define membrane identity and function, mediate vesicular docking and fusion
Clathrin-coated vesicles
, Coated vesicles that transport material endocytosed at the plasma membrane and
within endosomal compartments
Cis face of the Golgi
Side of the Golgi stack at which material enters
Golgi reassembly and stacking proteins (GRASPs)
Structural proteins that create a scaffold between adjacent cisternae to form the Golgi
stacks
SNAREs
Mediate vesicle docking and fusion to specific target membranes by winding into stable
4-helix complexes
Lysosomes
Membrane-bound organelle which contains digestive enzymes most active at low pH
Macropinocytosis
"Cell drinking", when a cell non-specifically traps extracellular fluid and material
Phosphoinositides (PIPs)
Variable phosphorylation of the 3', 4', and 5' position of this phosphilipid's sugar head
group recruits different proteins to create functionally distinct membrane domains
ER exit sites
COPII-coated vesicles bud from this specialized region of the ER that is devoid of
ribosomes
Mannose-6-phosphate (M6P)
This modification identifies acid (lysosome) hydrolases, formed by trimming GlcNAc
from N-linked glycosylation
