BIOL4004 EXAM II QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
tight junction
seals gap between epithelial cells and prevents leakage
tight junction functions
diffusion barrier, fences within the membrane
tight junction proteins
claudin and occludin
adherins
connects actin filaments
cadherins
cell-cell adhesion via adherins or desmosomes
characteristics of cadherins
Ca2+ dependent, facilitates selective cell sorting (low/high cad), mediate homophilic
adhesion
chelators
remove Ca2+ ions from cadherin, creates floppy cadherin
integrins
on the surface of cells that bind to ECM
desmosomes
connects intermediate filaments. button-like spots of adhesion
, gap junctions
cell-cell channels of small molecules
gap junctions can
create action potentials and can be opened/closed
gap junctions are formed by
connexons which form channels
hemidesmosomes
link intermediate filaments to ECM
ECM consists of
GAGs, fibrous proteins, glycoproteins
GAGs contain
hyaluronan (no protein), proteoglycans (protein)
proteoglycans
GAG chain linked to protein with serine residue
collagen formation
hydroxylation, procollagen assembly, propeptide removal, fibril formation
basil lamina consists of
laminin, type IV collagen
laminin
primary organizer of basal lamina
type IV collagen
network-forming, no fibrils (basal lamina)
type I and II collagen
COMPLETE SOLUTIONS GRADED A++ LATEST UPDATE
tight junction
seals gap between epithelial cells and prevents leakage
tight junction functions
diffusion barrier, fences within the membrane
tight junction proteins
claudin and occludin
adherins
connects actin filaments
cadherins
cell-cell adhesion via adherins or desmosomes
characteristics of cadherins
Ca2+ dependent, facilitates selective cell sorting (low/high cad), mediate homophilic
adhesion
chelators
remove Ca2+ ions from cadherin, creates floppy cadherin
integrins
on the surface of cells that bind to ECM
desmosomes
connects intermediate filaments. button-like spots of adhesion
, gap junctions
cell-cell channels of small molecules
gap junctions can
create action potentials and can be opened/closed
gap junctions are formed by
connexons which form channels
hemidesmosomes
link intermediate filaments to ECM
ECM consists of
GAGs, fibrous proteins, glycoproteins
GAGs contain
hyaluronan (no protein), proteoglycans (protein)
proteoglycans
GAG chain linked to protein with serine residue
collagen formation
hydroxylation, procollagen assembly, propeptide removal, fibril formation
basil lamina consists of
laminin, type IV collagen
laminin
primary organizer of basal lamina
type IV collagen
network-forming, no fibrils (basal lamina)
type I and II collagen
