PATHOPHYSIOLOGY
The Biologic Basis For Disease InAdults
n n n n n n n
And Children
n
8THEDITION BY KATHRYN L.MC
n n n n n
CANCE
,McCance:nPathophysiology:nThenBiologicnBasisnfornDiseaseninnAdultsnandnChildrenn(8thnEdition)nTESTnBAN
K
CONTENTS:
Chaptern01:nCellularnBiology
Chaptern02:nAlterednCellularnandnTissuenBiology:nEnvironmentalnAgents
Chaptern03:nThenCellularnEnvironment:nFluidsnandnElectrolytes,nAcidsnandnBases
Chaptern04:nGenesnandnGeneticnDiseases
Chaptern05:nGenes,nEnvironment-Lifestyle,nandnCommonnDiseases
Chaptern06:nEpigeneticsnandnDisease
Chaptern07:nInnatenImmunity:nInflammationnandnWoundnHealing
Chaptern08:nAdaptivenImmunity
Chaptern09:nAlterationsninnImmunitynandnInflammation
Chaptern10:nInfection
Chaptern11:nStressnandnDisease
Chaptern12:nCancernBiology
Chaptern13:nCancernEpidemiology
Chaptern14:nCancerninnChildren
Chaptern15:nStructurenandnFunctionnofnthenNeurologicnSystem
Chaptern16:nPain,nTemperaturenRegulation,nSleep,nandnSensorynFunction
Chaptern17:nAlterationsninnCognitivenSystems,nCerebralnHemodynamics,nandnMotornFunction
Chaptern18:nDisordersnofnthenCentralnandnPeripheralnNervousnSystemsnandnthenNeuromuscularnJunction
Chaptern19:nNeurobiologynofnSchizophrenia,nMoodnDisorders,nandnAnxietynDisorders
Chaptern20:nAlterationsnofnNeurologicnFunctionninnChildren
Chaptern21:nMechanismsnofnHormonalnRegulation
Chaptern22:nAlterationsnofnHormonalnRegulation
Chaptern23:nObesitynandnDisordersnofnNutrition
Chaptern24:nStructurenandnFunctionnofnthenReproductivenSystems
Chaptern25:nAlterationsnofnthenFemalenReproductivenSystem
Chaptern26:nAlterationsnofnthenMalenReproductivenSystem
Chaptern27:nSexuallynTransmittednInfections
Chaptern28:nStructurenandnFunctionnofnthenHematologicnSystem
Chaptern29:nAlterationsnofnErythrocytes,nPlatelets,nandnHemostaticnFunction
Chaptern30:nAlterationsnofnLeukocytenandnLymphoidnFunction
Chaptern31:nAlterationsnofnHematologicnFunctionninnChildren
Chaptern32:nStructurenandnFunctionnofnthenCardiovascularnandnLymphaticnSystems
Chaptern33:nAlterationsnofnCardiovascularnFunction
Chaptern34:nAlterationsnofnCardiovascularnFunctionninnChildren
Chaptern35:nStructurenandnFunctionnofnthenPulmonarynSystem
Chaptern36:nAlterationsnofnPulmonarynFunction
Chaptern37:nAlterationsnofnPulmonarynFunctionninnChildren
Chaptern38:nStructurenandnFunctionnofnthenRenalnandnUrologicnSystems
Chaptern39:nAlterationsnofnRenalnandnUrinarynTractnFunction
Chaptern40:nAlterationsnofnRenalnandnUrinarynTractnFunctionninnChildren
Chaptern41:nStructurenandnFunctionnofnthenDigestivenSystem
Chaptern42:nAlterationsnofnDigestivenFunction
Chaptern43:nAlterationsnofnDigestivenFunctionninnChildren
Chaptern44:nStructurenandnFunctionnofnthenMusculoskeletalnSystem
Chaptern45:nAlterationsnofnMusculoskeletalnFunction
Chaptern46:nAlterationsnofnMusculoskeletalnFunctionninnChildren
Chaptern47:nStructure,nFunction,nandnDisordersnofnthenIntegument
Chaptern48:nAlterationsnofnthenIntegumentninnChildren
Chaptern49:nShock,nMultiplenOrgannDysfunctionnSyndrome,nandnBurnsninnAdults
Chaptern50:nShock,nMultiplenOrgannDysfunctionnSyndrome,nandnBurnsninnChildren
, McCance:nPathophysiology:nThenBiologicnBasisnfornDiseaseninnAdultsnandnChildrenn(8thnEdition)nTESTnBANK
Partn1:nCENTRALnCONCEPTSnOFnPATHOPHYSIOLOGY:nCELLSnANDnTISSUESn
UnitnI:nTHEnCELL
CHAPTERn01:nCELLULARnBIOLOGY
MULTIPLEnCHOICE
1. Whichnstatementnbestndescribesnthencellularnfunctionnofnmetabolicnabsorption?
a. Cellsncannproducenproteins.
b. Cellsncannsecretendigestivenenzymes.
c. Cellsncanntakeninnandnusennutrients.
d. Cellsncannsynthesizenfats.
ANS:n C
Innmetabolicnabsorption,nallncellsntakeninnandnusennutrientsnandnothernsubstancesnfromntheirnsurrou
ndings.nThenremainingnoptionsnarennotninclusiveninntheirndescriptionsnofncellularnmetabolicnabsorpt
ion.
PTS:nnn 1 DIF: CognitivenLevel:nRemembering
2. Wherenisnmostnofnancell’sngeneticninformation,nincludingnRNAnandnDNA,ncontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:n C
Thennucleusncontainsnthennucleolus,nansmallndensenstructurencomposednlargelynofnRNA,nmostnofnt
hencellularnDNA,nandnthenDNA-
bindingnproteins,nsuchnasnthenhistones,nwhichnregulatenitsnactivity.nThenmitochondrianarenresponsi
blenforncellularnrespirationnandnenergynproduction.
Ribosomes’nchiefnfunctionnisntonprovidensitesnforncellularnproteinnsynthesis.nLysosomesnfunctionna
snthenintracellularndigestivensystem.
PTS:nnn 1 DIF: CognitivenLevel:nRemembering
3. Whichncomponentnofnthencellnproducesnhydrogennperoxiden(H2O2)nbynusingnoxygenntonremovenh
ydrogennatomsnfromnspecificnsubstratesninnannoxidativenreaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:n B
, McCance:nPathophysiology:nThenBiologicnBasisnfornDiseaseninnAdultsnandnChildrenn(8thnEdition)nTESTnBANK
Peroxisomesnarensonnamednbecausentheynusuallyncontainnenzymesnthatnusenoxygenntonremovenhydr
ogennatomsnfromnspecificnsubstratesninnannoxidativenreactionnthatnproducesnH2O2,nwhichnisnanpower
fulnoxidantnandnpotentiallyndestructivenifnitnaccumulatesnornescapesnfromnperoxisomes.
RibosomesnarenRNA-
proteinncomplexesn(nucleoproteins)nthatnarensynthesizedninnthennucleolusnandnsecretednintonthency
toplasmnthroughnporesninnthennuclearnenvelopencallednnuclearnporencomplexes.nLysosomesnarensa
clikenstructuresnthatnoriginatenfromnthenGolgincomplexnandncontainnmorenthann40ndigestivenenzym
esncallednhydrolases,nwhichncatalyzenbondsninnproteins,nlipids,nnucleicnacids,nandncarbohydrates.n
Annendosomenisnanvesicalnthatnhasnbeennpinchednoffnfromnthencellularnmembrane.
PTS:nnn 1 DIF: CognitivenLevel:nRemembering
4. Whichncellncomponentnisncapablenofncellularnautodigestionnwhennitnisnreleasednduringncellninjury?
a. Ribosome
b. Golgincomplex
c. Smoothnendoplasmicnreticulum
d. Lysosomes
ANS:n D
Thenlysosomalnmembranenactsnasnanprotectivenshieldnbetweennthenpowerfulndigestivenenzymesnwi
thinnthenlysosomenandnthencytoplasm,npreventingntheirnleakagenintonthencytoplasmicnmatrix.nDisru
ptionnofnthenmembranenbynvariousntreatmentsnorncellularninjurynleadsntonanreleasenofnthenlysosomal
nenzymes,nwhichncannthennreactnwithntheirnspecificnsubstrates,ncausingncellularnself-
ndigestion.nThenchiefnfunctionnofnanribosomenisntonprovidensitesnforncellularnproteinnsynthesis.nThen
Golgincomplexnisnannetworknofnflattened,nsmoothnvesiclesnandnmembranesnoftennlocatednnearnthenc
ellnnucleus.nThensmoothnendoplasmicnreticulumnisninvolvedninnsteroidnhormonenproductionnandnre
movingntoxicnsubstancesnfromnthencell.
PTS:nnn 1 DIF: CognitivenLevel:nRemembering
5. WhichncAMP-mediatednresponsenisnrelatedntonantidiureticnhormone?
a. Increasednheartnratenandnforcenofncontraction
b. Secretionnofncortisol
c. Increasednretentionnofnwater
d. Breakdownnofnfat
ANS:n C
Antidiureticnhormonenleadsntonincreasednretentionnofnwaterninnthenbody.nEpinephrinencausesni
ncreasesninnheartnratenandnforcenofncontraction.n IncreasedncortisolnsecretionnisnduentonACTH.nB
reakdownnofnfatnisnduentonglucagon.
PTS:nnn 1 DIF: CognitivenLevel:nRemembering
6. DuringnwhichnphasenofnthencellncyclenisnDNAnsynthesized?
a. G1
b. S
c. G2
d. M