BIOC20 LEC 6 - CORONAVIRUS EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
LATEST UPDATE
Briefly describe the Coronavirus
Spherical envelop particles crowned with trimetric spikes
What diseases can Coronavirus cause
- Mostly cause respiratory illnesses in humans
- Rare cases can cause gastroenteritis and encephalitis
- Also vet diseases such as feline peritonitis, infectious bronchitis, murine hepatitis
SARS coronavirus transmission and origin
- Transmitted by direct contact, aerosol droplets, contaminated stool
- may have originated from a related bat coronavirus
SARS virus had not been observed in humans before 2002-2003, why so?
Increase in zoonotic spread, especially from bats
What are coronavirus virions and nucleocapsid structures like?
Enveloped virions containing helical nucleocapsids
How are its nucleocapsids found?
Nucleocapsids formed from viral N protein bound to viral RNA in a helical fashion
What makes coronavirus nucleocapsid special?
, - Corona actually resembles negative strand viruses due to its negative helical fashion,
most positive strands are icosahedral
- Most other '+' strand RNA viruses have nucleocapsids with icosahedral symmetry
Some coronaviruses may have a spherical core structure (shell) formed via
the .......
M protein, a spherical core with internal helical nucleocapsid
Coronavirus virions contain multiple......
envelope proteins (E)
What are the types of Coronavirus proteins?
Spike Proteins (S)
Membrane Protein (M)
Small Envelope protein (E)
Nucleocapsid Protein (N)
in some cases Hemagglutinin-Esterase Proteins (HE)
Explain the spike proteins
•Major surface transmembrane glycoprotein protruding from the surface
•Responsible for viral entry and tropism
•Targeted by neutralizing antibodies and T-Cells in infection à possible vaccine /
therapeutic target
•Generally forms trimers
Explain the spike protein domains and synthesis
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
LATEST UPDATE
Briefly describe the Coronavirus
Spherical envelop particles crowned with trimetric spikes
What diseases can Coronavirus cause
- Mostly cause respiratory illnesses in humans
- Rare cases can cause gastroenteritis and encephalitis
- Also vet diseases such as feline peritonitis, infectious bronchitis, murine hepatitis
SARS coronavirus transmission and origin
- Transmitted by direct contact, aerosol droplets, contaminated stool
- may have originated from a related bat coronavirus
SARS virus had not been observed in humans before 2002-2003, why so?
Increase in zoonotic spread, especially from bats
What are coronavirus virions and nucleocapsid structures like?
Enveloped virions containing helical nucleocapsids
How are its nucleocapsids found?
Nucleocapsids formed from viral N protein bound to viral RNA in a helical fashion
What makes coronavirus nucleocapsid special?
, - Corona actually resembles negative strand viruses due to its negative helical fashion,
most positive strands are icosahedral
- Most other '+' strand RNA viruses have nucleocapsids with icosahedral symmetry
Some coronaviruses may have a spherical core structure (shell) formed via
the .......
M protein, a spherical core with internal helical nucleocapsid
Coronavirus virions contain multiple......
envelope proteins (E)
What are the types of Coronavirus proteins?
Spike Proteins (S)
Membrane Protein (M)
Small Envelope protein (E)
Nucleocapsid Protein (N)
in some cases Hemagglutinin-Esterase Proteins (HE)
Explain the spike proteins
•Major surface transmembrane glycoprotein protruding from the surface
•Responsible for viral entry and tropism
•Targeted by neutralizing antibodies and T-Cells in infection à possible vaccine /
therapeutic target
•Generally forms trimers
Explain the spike protein domains and synthesis
