https://www.stuvia.com/
TEST BANK FOR MODERN BLOOD
BANKING & TRANSFUSION
PRACTICES 7TH EDITION BY DENISE
M HARMENING
ISBN; 13: 9780803668881, CHAPTER
1-29 COMPLETE GUIDE
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
’ ’ ’ ’ ’ ’ ’ ’ ’ ’
Multiple’Choice
Identify’the’choice’that’best’completes’the’statement’or’answers’the’question.
1. Which‘metabolic‘pathway‘is‘responsible‘for‘generating‘90%‘of‘the‘ATP‘for‘the‘RBC?
a. Pentose‘phosphate‘shunt c. Glycolysis
b. Luebering-Rapoport‘shunt d.‘ Methemoglobin‘reductase
2. A‘unit‘of‘blood‘was‘returned‘to‘the‘blood‘bank‘before‘it‘was‘spiked.‘Apparently‘the‘patient‘s‘IV‘failed.‘The‘unit‘
of‘blood‘was‘outside‘the‘blood‘bank‘for‘35‘minutes.‘Which‘of‘the‘statements‘below‘is‘most‘accurate?
a. The‘unit‘of‘blood‘should‘be‘discarded‘immediately.
b. The‘unit‘of‘blood‘can‘be‘returned‘to‘inventory.
c. The‘unit‘of‘blood‘must‘be‘transfused‘within‘4‘hours‘or‘be‘discarded‘at‘the‘end‘of‘that‘time.
d. The‘unit‘of‘blood‘must‘be‘transfused‘with‘24‘hours.
3. What‘is‘the‘average‘diameter‘of‘a‘platelet?
a. 5‘to‘10‘µm c. 1‘to‘2‘µm
b. 2‘to‘4‘µm d.‘ ‘ 4‘to‘6‘µm
4. In‘the‘normal‘hemoglobin-
oxygen‘dissociation‘curve,‘what‘percentage‘of‘oxygen‘is‘released‘to‘the‘tissues‘when‘PO2‘ averages‘40‘mm‘
Hg?
a. 75% c. 100%
b. 25% d.‘ 50%
5. What‘factors‘are‘known‘to‘influence‘platelet‘metabolism‘and‘function?
a. Storage‘temperature c. Platelet‘count
b. Initial‘pH d.‘ All‘of‘the‘above
6. Which‘of‘the‘following‘red‘blood‘cell‘morphologies‘may‘be‘present‘on‘the‘peripheral‘blood‘smear‘as‘a‘result‘of‘lo
ss‘of‘RBC‘membrane?
a. Spherocytes c. Burr‘cells
b. Target‘cells d.‘ Schistocytes
7. What‘does‘the‘term‘autologous’transfusion‘refer‘to?
a. A‘parent‘donating‘blood‘for‘his‘or‘her‘child
b. An‘individual‘donating‘blood‘for‘a‘friend
c. An‘individual‘donating‘blood‘for‘a‘relative
d. An‘individual‘donating‘blood‘for‘his‘or‘her‘own‘transfusion
8. What‘is‘the‘primary‘function‘of‘hemoglobin?
a. Iron‘metabolism c. Oxygen‘transport
b. Porphyrin‘synthesis d.‘ Signal‘transduction
9. All‘of‘the‘following‘areas‘of‘red‘blood‘cell‘biology‘are‘crucial‘for‘normal‘erythrocyte‘survival‘ except:
a. Cellular‘metabolism. c. Site‘of‘the‘ABO‘antigen‘attachment.
b. RBC‘membrane. d.‘ Hemoglobin‘structure.
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‗ 10.‘ What‘is‘the‘correct‘biochemical‘composition‘of‘the‘RBC‘membrane?
a. 52%‘protein,‘40%‘lipid,‘8%‘carbohydrate
b. 40%‘protein,‘8%‘lipid,‘52%‘carbohydrate
c. 8%‘protein,‘52%‘lipid,‘40%‘carbohydrate
d. 8%‘lipid,‘40%‘carbohydrate,‘52%‘protein
‗ 11.‘ All‘of‘the‘following‘biochemical‘changes‘are‘associated‘with‘loss‘of‘red‘blood‘cell‘viability‘upon‘storage
except:
a. Decreased‘pH. c. Increased‘ATP‘level.
b. Loss‘of‘red‘blood‘cell‘function. d.‘ Decreased‘glucose‘consumption.
‗ 12.‘ Which‘red‘blood‘cell‘preservative‘has‘a‘storage‘time‘of‘35‘days?
a. ACD c. AS-1
b. CPDA-1 d.‘ ‘ CPD
‗ 13.‘ The‘RBC‘membrane‘is‘relatively‘permeable‘to‘all‘of‘the‘following‘except:
a. Chloride. c. Bicarbonate.
b. Sodium. d.‘ Water.
‗ 14.‘What‘percentage‘of‘platelets‘is‘sequestered‘in‘the‘spleen‘as‘functional‘reserve‘after‘being‘released‘from‘the‘bon
e‘marrow?
a. 30% c. 10%
b. 50% d.‘ ‘ 25%
‗ 15.‘ What‘is‘the‘major‘biochemical‘consideration‘in‘platelet‘storage?
a. Glucose‘metabolism c. Production‘of‘carbon‘dioxide
b. Oxygen‘supply d.‘ Regulation‘of‘pH
‗ 16.‘What‘would‘the‘hemoglobin-
oxygen‘dissociation‘curve‘depict‘in‘a‘patient‘exhibiting‘clinical‘signs‘of‘alkalosis?
a. Normal c. Shift‘to‘the‘right
b. Shift‘to‘the‘left d.‘ None‘of‘the‘above
‗ 17.‘ Name‘the‘main‘lipid‘components‘of‘a‘red‘blood‘cell‘membrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d.‘ Glycophorin‘A
‗ 18.‘ The‘ABO‘blood‘groups‘were‘discovered‘in‘1901‘by‘whom?
a. Charles‘Drew c. Loutit‘and‘Mollison
b. Karl‘Landsteiner d.‘ Edward‘Lindeman
‗ 19.‘A‘standing‘order‘of‘platelets‘was‘shipped‘to‘your‘facility‘by‘your‘supplier.‘It‘was‘inadvertently‘left‘in‘the‘corner‘o
f‘the‘department‘until‘discovered‘36‘hours‘later.‘What‘would‘the‘appropriate‘action‘be‘for‘the‘blood‘banker?
a. If‘the‘temperature‘in‘the‘box‘was‘22‘+/-
‘2°C‘and‘the‘platelet‘swirl‘seemed‘OK,‘it‘would‘be‘OK‘to‘accept‘the‘unit‘into‘inventory.
b. The‘platelets‘have‘fallen‘outside‘the‘supplier‘s‘quality‘assurance.‘The‘unit‘should‘be‘discar
ded‘because‘the‘pH‘has‘probably‘dropped‘too‘low‘and‘platelet‘activation‘has‘been‘compro
mised.
c. If‘the‘temperature‘was‘1°C‘to‘6°C‘and‘the‘platelet‘swirl‘seemed‘OK,‘it‘would‘be‘OK‘to
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accept‘the‘unit‘into‘inventory.
d. If‘the‘platelets‘appeared‘OK‘and‘passed‘the‘platelet‘swirl‘test‘after‘being‘placed‘on‘the‘agit
ator,‘they‘could‘be‘accepted‘into‘the‘inventory.
‗ 20.‘ Which‘metabolic‘pathway‘permits‘the‘accumulation‘of‘2,3‘diphosphoglycerate‘(2,3-DPG)?
a. Glycolysis c. Pentose‘phosphate‘shunt
b. Luebering-Rapoport‘shunt d.‘ Methemoglobin‘reductase
‗ 21.‘ All‘of‘the‘following‘are‘consistent‘with‘a‘"shift‘to‘the‘right"‗of‘the‘hemoglobin-oxygen‘dissociation‘curve
except:
a. Increased‘2,3-DPG.
b. 50%‘O2‘ saturation‘to‘tissues.
c. Decreased‘2,3-DPG.
d. Decreased‘hemoglobin‘affinity‘for‘O2.
‗ 22.‘ What‘is‘the‘normal‘platelet‘count‘range‘per‘cubic‘millimeter?
a. 100‘to‘350 c. 50,000‘to‘200,000
b. 150,000‘to‘350,000 d.‘ 350,000‘to‘500,000
‗ 23.‘ What‘cryoprotective‘agent‘is‘added‘to‘red‘blood‘cells‘upon‘freezing?
a. Dextrose c. Glycerol
b. Adsol d.‘ All‘of‘the‘above
‗ 24.‘ If‘platelets‘are‘to‘be‘stored‘for‘5‘days‘on‘a‘rotator,‘what‘is‘the‘optimal‘storage‘temperature?
a. 1°C‘to‘6°C c. 35°C‘to‘37°C
b. 20°C‘to‘24°C d.‘ 1°C‘to‘10°C
‗ 25.‘ What‘role‘do‘platelets‘play‘in‘hemostasis?
a. Maintenance‘of‘vascular‘integrity
b. Initial‘arrest‘of‘bleeding‘by‘platelet‘plug‘formation
c. Stabilization‘of‘the‘hemostatic‘plug
d. All‘of‘the‘above
‗ 26.‘ Which‘of‘the‘following‘best‘describes‘"integral"‗membrane‘proteins?
a. Reside‘at‘the‘cytoplasmic‘surface‘of‘membrane
b. Span‘the‘entire‘membrane‘surface
c. Form‘the‘red‘blood‘cell‘cytoskeleton
d. None‘of‘the‘above
‗ 27.‘ How‘is‘stroma-free‘hemoglobin‘solution‘prepared?
a. Outdated‘red‘blood‘cells‘are‘concentrated,‘and‘stroma‘is‘removed.
b. Outdated‘red‘blood‘cells‘are‘diluted‘with‘saline,‘and‘stroma‘is‘removed.
c. Outdated‘red‘blood‘cells‘are‘lysed,‘and‘stroma‘is‘removed.
d. None‘of‘the‘above
‗ 28.‘ What‘is‘the‘normal‘life‘span‘of‘an‘RBC?
a. 100‘days c. 120‘hours
b. 120‘days d.‘ 2‘days
‗ 29.‘ Regarding‘loss‘of‘RBC‘membrane‘deformability,‘all‘of‘the‘following‘are‘true‘except:
a. Increase‘in‘ATP‘level.
b. Decrease‘in‘ATP‘level.
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TEST BANK FOR MODERN BLOOD
BANKING & TRANSFUSION
PRACTICES 7TH EDITION BY DENISE
M HARMENING
ISBN; 13: 9780803668881, CHAPTER
1-29 COMPLETE GUIDE
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
’ ’ ’ ’ ’ ’ ’ ’ ’ ’
Multiple’Choice
Identify’the’choice’that’best’completes’the’statement’or’answers’the’question.
1. Which‘metabolic‘pathway‘is‘responsible‘for‘generating‘90%‘of‘the‘ATP‘for‘the‘RBC?
a. Pentose‘phosphate‘shunt c. Glycolysis
b. Luebering-Rapoport‘shunt d.‘ Methemoglobin‘reductase
2. A‘unit‘of‘blood‘was‘returned‘to‘the‘blood‘bank‘before‘it‘was‘spiked.‘Apparently‘the‘patient‘s‘IV‘failed.‘The‘unit‘
of‘blood‘was‘outside‘the‘blood‘bank‘for‘35‘minutes.‘Which‘of‘the‘statements‘below‘is‘most‘accurate?
a. The‘unit‘of‘blood‘should‘be‘discarded‘immediately.
b. The‘unit‘of‘blood‘can‘be‘returned‘to‘inventory.
c. The‘unit‘of‘blood‘must‘be‘transfused‘within‘4‘hours‘or‘be‘discarded‘at‘the‘end‘of‘that‘time.
d. The‘unit‘of‘blood‘must‘be‘transfused‘with‘24‘hours.
3. What‘is‘the‘average‘diameter‘of‘a‘platelet?
a. 5‘to‘10‘µm c. 1‘to‘2‘µm
b. 2‘to‘4‘µm d.‘ ‘ 4‘to‘6‘µm
4. In‘the‘normal‘hemoglobin-
oxygen‘dissociation‘curve,‘what‘percentage‘of‘oxygen‘is‘released‘to‘the‘tissues‘when‘PO2‘ averages‘40‘mm‘
Hg?
a. 75% c. 100%
b. 25% d.‘ 50%
5. What‘factors‘are‘known‘to‘influence‘platelet‘metabolism‘and‘function?
a. Storage‘temperature c. Platelet‘count
b. Initial‘pH d.‘ All‘of‘the‘above
6. Which‘of‘the‘following‘red‘blood‘cell‘morphologies‘may‘be‘present‘on‘the‘peripheral‘blood‘smear‘as‘a‘result‘of‘lo
ss‘of‘RBC‘membrane?
a. Spherocytes c. Burr‘cells
b. Target‘cells d.‘ Schistocytes
7. What‘does‘the‘term‘autologous’transfusion‘refer‘to?
a. A‘parent‘donating‘blood‘for‘his‘or‘her‘child
b. An‘individual‘donating‘blood‘for‘a‘friend
c. An‘individual‘donating‘blood‘for‘a‘relative
d. An‘individual‘donating‘blood‘for‘his‘or‘her‘own‘transfusion
8. What‘is‘the‘primary‘function‘of‘hemoglobin?
a. Iron‘metabolism c. Oxygen‘transport
b. Porphyrin‘synthesis d.‘ Signal‘transduction
9. All‘of‘the‘following‘areas‘of‘red‘blood‘cell‘biology‘are‘crucial‘for‘normal‘erythrocyte‘survival‘ except:
a. Cellular‘metabolism. c. Site‘of‘the‘ABO‘antigen‘attachment.
b. RBC‘membrane. d.‘ Hemoglobin‘structure.
This‘study‘source‘was‘downloaded‘by‘100000826342158‘from‘CourseHero.com‘on‘09-15-2021‘17:54:15‘GMT‘-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
‗ 10.‘ What‘is‘the‘correct‘biochemical‘composition‘of‘the‘RBC‘membrane?
a. 52%‘protein,‘40%‘lipid,‘8%‘carbohydrate
b. 40%‘protein,‘8%‘lipid,‘52%‘carbohydrate
c. 8%‘protein,‘52%‘lipid,‘40%‘carbohydrate
d. 8%‘lipid,‘40%‘carbohydrate,‘52%‘protein
‗ 11.‘ All‘of‘the‘following‘biochemical‘changes‘are‘associated‘with‘loss‘of‘red‘blood‘cell‘viability‘upon‘storage
except:
a. Decreased‘pH. c. Increased‘ATP‘level.
b. Loss‘of‘red‘blood‘cell‘function. d.‘ Decreased‘glucose‘consumption.
‗ 12.‘ Which‘red‘blood‘cell‘preservative‘has‘a‘storage‘time‘of‘35‘days?
a. ACD c. AS-1
b. CPDA-1 d.‘ ‘ CPD
‗ 13.‘ The‘RBC‘membrane‘is‘relatively‘permeable‘to‘all‘of‘the‘following‘except:
a. Chloride. c. Bicarbonate.
b. Sodium. d.‘ Water.
‗ 14.‘What‘percentage‘of‘platelets‘is‘sequestered‘in‘the‘spleen‘as‘functional‘reserve‘after‘being‘released‘from‘the‘bon
e‘marrow?
a. 30% c. 10%
b. 50% d.‘ ‘ 25%
‗ 15.‘ What‘is‘the‘major‘biochemical‘consideration‘in‘platelet‘storage?
a. Glucose‘metabolism c. Production‘of‘carbon‘dioxide
b. Oxygen‘supply d.‘ Regulation‘of‘pH
‗ 16.‘What‘would‘the‘hemoglobin-
oxygen‘dissociation‘curve‘depict‘in‘a‘patient‘exhibiting‘clinical‘signs‘of‘alkalosis?
a. Normal c. Shift‘to‘the‘right
b. Shift‘to‘the‘left d.‘ None‘of‘the‘above
‗ 17.‘ Name‘the‘main‘lipid‘components‘of‘a‘red‘blood‘cell‘membrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d.‘ Glycophorin‘A
‗ 18.‘ The‘ABO‘blood‘groups‘were‘discovered‘in‘1901‘by‘whom?
a. Charles‘Drew c. Loutit‘and‘Mollison
b. Karl‘Landsteiner d.‘ Edward‘Lindeman
‗ 19.‘A‘standing‘order‘of‘platelets‘was‘shipped‘to‘your‘facility‘by‘your‘supplier.‘It‘was‘inadvertently‘left‘in‘the‘corner‘o
f‘the‘department‘until‘discovered‘36‘hours‘later.‘What‘would‘the‘appropriate‘action‘be‘for‘the‘blood‘banker?
a. If‘the‘temperature‘in‘the‘box‘was‘22‘+/-
‘2°C‘and‘the‘platelet‘swirl‘seemed‘OK,‘it‘would‘be‘OK‘to‘accept‘the‘unit‘into‘inventory.
b. The‘platelets‘have‘fallen‘outside‘the‘supplier‘s‘quality‘assurance.‘The‘unit‘should‘be‘discar
ded‘because‘the‘pH‘has‘probably‘dropped‘too‘low‘and‘platelet‘activation‘has‘been‘compro
mised.
c. If‘the‘temperature‘was‘1°C‘to‘6°C‘and‘the‘platelet‘swirl‘seemed‘OK,‘it‘would‘be‘OK‘to
This‘study‘source‘was‘downloaded‘by‘100000826342158‘from‘CourseHero.com‘on‘09-15-2021‘17:54:15‘GMT‘-05:00
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accept‘the‘unit‘into‘inventory.
d. If‘the‘platelets‘appeared‘OK‘and‘passed‘the‘platelet‘swirl‘test‘after‘being‘placed‘on‘the‘agit
ator,‘they‘could‘be‘accepted‘into‘the‘inventory.
‗ 20.‘ Which‘metabolic‘pathway‘permits‘the‘accumulation‘of‘2,3‘diphosphoglycerate‘(2,3-DPG)?
a. Glycolysis c. Pentose‘phosphate‘shunt
b. Luebering-Rapoport‘shunt d.‘ Methemoglobin‘reductase
‗ 21.‘ All‘of‘the‘following‘are‘consistent‘with‘a‘"shift‘to‘the‘right"‗of‘the‘hemoglobin-oxygen‘dissociation‘curve
except:
a. Increased‘2,3-DPG.
b. 50%‘O2‘ saturation‘to‘tissues.
c. Decreased‘2,3-DPG.
d. Decreased‘hemoglobin‘affinity‘for‘O2.
‗ 22.‘ What‘is‘the‘normal‘platelet‘count‘range‘per‘cubic‘millimeter?
a. 100‘to‘350 c. 50,000‘to‘200,000
b. 150,000‘to‘350,000 d.‘ 350,000‘to‘500,000
‗ 23.‘ What‘cryoprotective‘agent‘is‘added‘to‘red‘blood‘cells‘upon‘freezing?
a. Dextrose c. Glycerol
b. Adsol d.‘ All‘of‘the‘above
‗ 24.‘ If‘platelets‘are‘to‘be‘stored‘for‘5‘days‘on‘a‘rotator,‘what‘is‘the‘optimal‘storage‘temperature?
a. 1°C‘to‘6°C c. 35°C‘to‘37°C
b. 20°C‘to‘24°C d.‘ 1°C‘to‘10°C
‗ 25.‘ What‘role‘do‘platelets‘play‘in‘hemostasis?
a. Maintenance‘of‘vascular‘integrity
b. Initial‘arrest‘of‘bleeding‘by‘platelet‘plug‘formation
c. Stabilization‘of‘the‘hemostatic‘plug
d. All‘of‘the‘above
‗ 26.‘ Which‘of‘the‘following‘best‘describes‘"integral"‗membrane‘proteins?
a. Reside‘at‘the‘cytoplasmic‘surface‘of‘membrane
b. Span‘the‘entire‘membrane‘surface
c. Form‘the‘red‘blood‘cell‘cytoskeleton
d. None‘of‘the‘above
‗ 27.‘ How‘is‘stroma-free‘hemoglobin‘solution‘prepared?
a. Outdated‘red‘blood‘cells‘are‘concentrated,‘and‘stroma‘is‘removed.
b. Outdated‘red‘blood‘cells‘are‘diluted‘with‘saline,‘and‘stroma‘is‘removed.
c. Outdated‘red‘blood‘cells‘are‘lysed,‘and‘stroma‘is‘removed.
d. None‘of‘the‘above
‗ 28.‘ What‘is‘the‘normal‘life‘span‘of‘an‘RBC?
a. 100‘days c. 120‘hours
b. 120‘days d.‘ 2‘days
‗ 29.‘ Regarding‘loss‘of‘RBC‘membrane‘deformability,‘all‘of‘the‘following‘are‘true‘except:
a. Increase‘in‘ATP‘level.
b. Decrease‘in‘ATP‘level.
This‘study‘source‘was‘downloaded‘by‘100000826342158‘from‘CourseHero.com‘on‘09-15-2021‘17:54:15‘GMT‘-05:00
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