NR 507 Autoimmunity Questions with Solutions

NR 507 Autoimmunity

Sjogren’s Syndrome - answer_____ is associated with autoantibodies and auto-reactive
T-cells against apoptotic cells

Antinuclear Antibody (ANA) - answer The ________ test is positive in 90% of patients
diagnosed with Systemic Lupus Erythematosus (SLE).

Autoimmunity - answer_____ is an alteration in the ability of the body to tolerate its own
self-antigens.

Autoimmune - answer The _______ damage is caused by the autoantibodies and T-
cells, to the extent that tissue damage occurs. Presenting clinical manifestations will
depend on the area of the body affected. Regardless of the affected body area,
autoantibodies and T-cells, and in some cases, B-cells, react in the associated body
system to produce the characteristic signs and symptoms.

Rheumatoid Arthritis, Systemic Lupus Erythematosus, Multiple Sclerosis, and Sjogren's
Syndrome. - answer Autoimmune diseases include:

Systemic Lupus Erythematosus (SLE) - answerCommon Manifestations
Tissue inflammation, vasculitis, rash, tissue inflammation.

Immune System Changes
Autoantibodies and auto-active T-cells against DNA and nucleoprotein antigens

Rheumatoid Arthritis (RA) - answerCommon Manifestations
Joint inflammation, stiffness and pain; loss of range of motion

Immune System Changes
Autoantibodies and auto-reactive T-cells and B-cells against joint-associated antigens

Multiple Sclerosis (MS) - answerCommon Manifestations
Formation of sclerotic plaque in the brain; leads to muscle weakness and ataxia

Immune System Changes
Autoantibodies and auto-reactive T-cells against brain antigens

Sjogren's Syndrome - answerCommon Manifestations
Inflammation in salivary and lacrimal glands

Immune System Changes
Autoantibodies and auto-reactive T-cells against apoptotic cells