Immunology Test Bank-200+ questions with 100% verified answers
The germinal centers found in the cortical region of lymph nodes and the peripheral region of
splenic periarteriolar lymphatic tissue: - correct answer contains large populations of B
lymphocytes and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections.
Thus, in case of Mycobacterium leprae infection: - correct answer tuberculoid leprosy will occur
in patients with a prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The MHC molecule located around the peptide-binding cleft is recognized by the: -
correct answer CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - correct answer neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - correct answer recognize pathogen-associated molecular patterns
(PAMPs) on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: - correct answer
CD3 and ζ molecules
Which of the following is considered a primary lymphoid organ? - correct answer thymus
Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - correct answer MHC class II molecules
Immunologic memory refers to: - correct answer changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - correct answer L-selectin
The main consequences of complement activation are all of the following EXCEPT: - correct
answer producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - correct answer dendritic cells
located mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte
zone) EXCEPT: - correct answer short-lived plasma cells
The antigen recognition on the T cells is mediated by: - correct answer the Variable (v) regions
of α and β chains
,Immunology Test Bank-200+ questions with 100% verified answers
The T-cell receptor: - correct answer recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? - correct
answer Clones of lymphocytes specific for antigens develop prior to exposure to the antigens
Which of the following best describes the T-dependent antibody response? - correct answer IT
is the response of follicular B lymphocytes to a protein antigen and characterized by isotope-
switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - correct answer One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the
following EXCEPT: - correct answer antigen presentation to the T cells in the follicles of the
lymph nodes
The phases and order of the specific or acquired immune responses are: - correct answer
recognition phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit
and activate different cell types. The IFN-γ is produced mainly by: - correct answer CD4+ T cell
TH1 subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage
and B lymphocytes by: - correct answer CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J
gene segments in different clones of lymphocytes is the result of: - correct answer both
combinatorial diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: - correct
answer recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was
infected with rabies virus, is administration of human immunoglobulin preparations containing
anti-rabies virus antibodies. Which type of immunity would be established by this treatment? -
correct answer passive humoral immunity
The steps in the activation of T lymphocytes against a specific antigen takes place int he
following order: - correct answer antigen recognition, activation, clonal expansion,
differentiation into effector cells & memory cells
Antigen recognition by T cells induces signal transduction through biochemical intermediates
which will activate enzymes responsible for activation of Transcriptional Factors. This activation
may be blocked by: - correct answer cyclosporine
, Immunology Test Bank-200+ questions with 100% verified answers
The CD8+ cytolytic T lymphocyte (CTL) uses different mechanisms to kill the target cell.
Caspase-activating proteins of the CTL granules are called: - correct answer granzyme B
Regarding the recognition of microbes by innate immune system, all of the following are true
EXCEPT: - correct answer the innate system responds more efficiently to each successive
encounter with a microbe
The adaptive immune system uses all of the following strategies to combat the majority of
microbes EXCEPT: - correct answer many plasma proteins involved in host defense, including
the cytokines and interleukins, which are activated by microbes, and whose products kill
microbes
Which of the following receptors on the T cells is involved in signal transduction TO the APCs? -
correct answer CD40 ligand
Regarding primary and secondary antibody responses, all of the following are true EXCEPT: -
correct answer the lag period is shorter in the primary response
Which of the following functions DOES NOT occur in lymph nodes? - correct answer blood
filtration of microbes
Which of the following is NOT true about the CD4 and CD8 cell markers? - correct answer both
of the markers are present in the naive mature T-cell
Which of the following is NOT true of the ability of the T cell receptor (TCR) to specifically
recognize antigen? - correct answer Only the alpha chain of the TCR is necessary for antigen
recognition
The majority of T lymphocytes recognize _______ antigens that are bound to and displayed by
the major histocompatibility complex (MHC) molecules of antigen-presenting cells (APCs). -
correct answer protein
ß-2 microglobulin is an integral part of - correct answer MHC class I molecule
CD40 Ligand (CD154) is expressed by which of the following cells? - correct answer Activated T
cells
MHC class I molecules contain: - correct answer One α and one ß-2 microglobulin
Respiratory burst is the release of reactive oxygen species (superoxide radical and hydrogen
peroxide) during all of the following intracellular microbial killing EXCEPT: - correct answer
activation of lysosomal enzymes in the phagolysosomes
The germinal centers found in the cortical region of lymph nodes and the peripheral region of
splenic periarteriolar lymphatic tissue: - correct answer contains large populations of B
lymphocytes and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular infections.
Thus, in case of Mycobacterium leprae infection: - correct answer tuberculoid leprosy will occur
in patients with a prominent TH1 response
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The MHC molecule located around the peptide-binding cleft is recognized by the: -
correct answer CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - correct answer neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - correct answer recognize pathogen-associated molecular patterns
(PAMPs) on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing ligands
on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: - correct answer
CD3 and ζ molecules
Which of the following is considered a primary lymphoid organ? - correct answer thymus
Immediate activation of the B lymphocytes following contact with the antigen involves all of the
following molecules EXCEPT: - correct answer MHC class II molecules
Immunologic memory refers to: - correct answer changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - correct answer L-selectin
The main consequences of complement activation are all of the following EXCEPT: - correct
answer producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - correct answer dendritic cells
located mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B lymphocyte
zone) EXCEPT: - correct answer short-lived plasma cells
The antigen recognition on the T cells is mediated by: - correct answer the Variable (v) regions
of α and β chains
,Immunology Test Bank-200+ questions with 100% verified answers
The T-cell receptor: - correct answer recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? - correct
answer Clones of lymphocytes specific for antigens develop prior to exposure to the antigens
Which of the following best describes the T-dependent antibody response? - correct answer IT
is the response of follicular B lymphocytes to a protein antigen and characterized by isotope-
switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - correct answer One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all of the
following EXCEPT: - correct answer antigen presentation to the T cells in the follicles of the
lymph nodes
The phases and order of the specific or acquired immune responses are: - correct answer
recognition phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that recruit
and activate different cell types. The IFN-γ is produced mainly by: - correct answer CD4+ T cell
TH1 subset
TH1 subset effector cells that aid in cell mediated immune response activate the macrophage
and B lymphocytes by: - correct answer CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D, and J
gene segments in different clones of lymphocytes is the result of: - correct answer both
combinatorial diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: - correct
answer recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal was
infected with rabies virus, is administration of human immunoglobulin preparations containing
anti-rabies virus antibodies. Which type of immunity would be established by this treatment? -
correct answer passive humoral immunity
The steps in the activation of T lymphocytes against a specific antigen takes place int he
following order: - correct answer antigen recognition, activation, clonal expansion,
differentiation into effector cells & memory cells
Antigen recognition by T cells induces signal transduction through biochemical intermediates
which will activate enzymes responsible for activation of Transcriptional Factors. This activation
may be blocked by: - correct answer cyclosporine
, Immunology Test Bank-200+ questions with 100% verified answers
The CD8+ cytolytic T lymphocyte (CTL) uses different mechanisms to kill the target cell.
Caspase-activating proteins of the CTL granules are called: - correct answer granzyme B
Regarding the recognition of microbes by innate immune system, all of the following are true
EXCEPT: - correct answer the innate system responds more efficiently to each successive
encounter with a microbe
The adaptive immune system uses all of the following strategies to combat the majority of
microbes EXCEPT: - correct answer many plasma proteins involved in host defense, including
the cytokines and interleukins, which are activated by microbes, and whose products kill
microbes
Which of the following receptors on the T cells is involved in signal transduction TO the APCs? -
correct answer CD40 ligand
Regarding primary and secondary antibody responses, all of the following are true EXCEPT: -
correct answer the lag period is shorter in the primary response
Which of the following functions DOES NOT occur in lymph nodes? - correct answer blood
filtration of microbes
Which of the following is NOT true about the CD4 and CD8 cell markers? - correct answer both
of the markers are present in the naive mature T-cell
Which of the following is NOT true of the ability of the T cell receptor (TCR) to specifically
recognize antigen? - correct answer Only the alpha chain of the TCR is necessary for antigen
recognition
The majority of T lymphocytes recognize _______ antigens that are bound to and displayed by
the major histocompatibility complex (MHC) molecules of antigen-presenting cells (APCs). -
correct answer protein
ß-2 microglobulin is an integral part of - correct answer MHC class I molecule
CD40 Ligand (CD154) is expressed by which of the following cells? - correct answer Activated T
cells
MHC class I molecules contain: - correct answer One α and one ß-2 microglobulin
Respiratory burst is the release of reactive oxygen species (superoxide radical and hydrogen
peroxide) during all of the following intracellular microbial killing EXCEPT: - correct answer
activation of lysosomal enzymes in the phagolysosomes
