NH2
↓
BP : 17 20 73
is <basic than
alky/ amine ↓ ↓ I
H-N -
CH3
H-N- CHs H, -N -
CH2
3 HB IHB OAB
I
It
I
c'Is
CH3
10 amine 20 Amine 30 Amine
Basicity
·
Amine =
Lewis bases
o -
NH2 :
weak base (able to share lone pair to acid)
·
↓PKn ,
4 base.
CAAAL
CHCNN)
EDG calcono , alkylamines EWG
CHalogen Carbonyl , nitrile
, , nitro )
CEN No
EDS & basicity ↓
basicity
· ·
Nu-
Substitu
Preparation - Reaction
↓ Red 1 N
-
u= c -
NH2
① Reduction of Aromatic Nitro Compound ① w Carboxylic Acid (Nucl .
subst .
Uxth)
C
R
: j: R
R Hz + Pt
i 8
:
[Fe/
I I Il I
Sn + Acid Rc -
x + H -
N -
R
·
R -
c -
[ :
RC -
N -
R +
H
1. .
P :
1.Amine [NO2 - >
NHz] HNRz
t
(intermediatel
② Sulfonic (NSR)
NOnAP enE Acids
Gent N
R P
② Red · Of Nitrile Aromatic sulfonyl chloride- > Sulfa drugs
R :
2 H2
It bacterial growth)
Ini
p :
1 Amine [1H =
-C
,
H = -N)
-
RCEN # RCHINA ↓
+
2H2 ,
&
③ Red · of Amide
LiAl
M :
T
P :
/" ,
20
,
30 amine [ = 0
hilang ganti ,
it]
O
sir
11
LiAlH4
RCNH2 > RCH2NH2
H2 s
↓
-mcm p-aminobenz Acid
⑦
-
Alkylation
- S
* of Amine by nucl .
Subst.
↓
tanam ? R : Amine (Nut V bacteria growth
[alky Sw2 mechanism
*
/ nalide
It H
+
CHIN : + CHs-cl-> Transition - > CHINCHaCl
H State H
Nin CH3 ii)
↓
BP : 17 20 73
is <basic than
alky/ amine ↓ ↓ I
H-N -
CH3
H-N- CHs H, -N -
CH2
3 HB IHB OAB
I
It
I
c'Is
CH3
10 amine 20 Amine 30 Amine
Basicity
·
Amine =
Lewis bases
o -
NH2 :
weak base (able to share lone pair to acid)
·
↓PKn ,
4 base.
CAAAL
CHCNN)
EDG calcono , alkylamines EWG
CHalogen Carbonyl , nitrile
, , nitro )
CEN No
EDS & basicity ↓
basicity
· ·
Nu-
Substitu
Preparation - Reaction
↓ Red 1 N
-
u= c -
NH2
① Reduction of Aromatic Nitro Compound ① w Carboxylic Acid (Nucl .
subst .
Uxth)
C
R
: j: R
R Hz + Pt
i 8
:
[Fe/
I I Il I
Sn + Acid Rc -
x + H -
N -
R
·
R -
c -
[ :
RC -
N -
R +
H
1. .
P :
1.Amine [NO2 - >
NHz] HNRz
t
(intermediatel
② Sulfonic (NSR)
NOnAP enE Acids
Gent N
R P
② Red · Of Nitrile Aromatic sulfonyl chloride- > Sulfa drugs
R :
2 H2
It bacterial growth)
Ini
p :
1 Amine [1H =
-C
,
H = -N)
-
RCEN # RCHINA ↓
+
2H2 ,
&
③ Red · of Amide
LiAl
M :
T
P :
/" ,
20
,
30 amine [ = 0
hilang ganti ,
it]
O
sir
11
LiAlH4
RCNH2 > RCH2NH2
H2 s
↓
-mcm p-aminobenz Acid
⑦
-
Alkylation
- S
* of Amine by nucl .
Subst.
↓
tanam ? R : Amine (Nut V bacteria growth
[alky Sw2 mechanism
*
/ nalide
It H
+
CHIN : + CHs-cl-> Transition - > CHINCHaCl
H State H
Nin CH3 ii)
