b b
Weekb1b:bIntroductionbtobClinicalbHematology
1. WhatbdobyoubcallbwhenbtherebisbanbincreasebinbBandsbneutrophilband
bsignalsbabbacterialbinfection.
A. Leftbshift
B. Neutropenia
C. Neutrophilia
D. SegmentedbNeutrophil
Rationale:
Leftbshiftbisbthebcorrectbanswerbbecausebitbisbwherebtherebisbanbincreasebofbi
mmaturebwhitebbloodbcellsbthatbsignifiesbinfectionborbinflammation.b
Neutropeniabisbnotbthebanswerbbecausebthisbtermbrefersbtobabdecreasedbnu
mberbofbneutrophils.
Neutrophiliabisbnotbthebanswerbbecausebitbisbthebtermbusedbwhenbtherebisba
nbincreasedbnumberbofbneutrophils.
SegmentedbNeutrophilbisbnotbthebanswerbbecausebthisbrefersbtobtheirbmultil
obedbnuclei.
Referenceb:bRodak’sbHematologyb
ClinicalbPrinciplesbandbApplications,b
SixbEdition,bChapterb1,bP3.
2. Whichbofbthebfollowingbstatementsbisbtruebaboutbplatelets.
I. Truebcellsbthatbmaintainbbloodbvesselbintegrity.
II. Adherebtobthebsurfacesbofbdamagedbbloodbvessels.
III. 0btob14bumbinbdiameter.
IV. Cellbfragments
A. I,bII,bandbIII
B. I,bII,bandbIV
C. IbandbIV
D. Allbofbthebchoicesbarebcorrect
Rationale:
,LetterbAbisbnotbthebanswerbbecausebIIIbisbincorrect,thebsizebofbplateletbisb2btob
4bumbinbdiameter.
LetterbBbisbthebcorrectbanswerbbecausebIIIbisbnotbincludedbinbthebchoices.bPl
ateletbalsobknownbasbcellbfragmentsbarebtruebcellsbthatbmaintainbbloodbvess
elbintegritybbybinitiatingbvesselbwallbrepair.b.b
LetterbCbisbnotbthebanswerbbecausebIIbshouldbbebincluded,bplateletsbadherebt
obdamagedbbloodbvesselsbforbrepair..b
LetterbDbisbnotbthebanswerbbecausebIIIbisbincorrect.
Referenceb:bRodak’sbHematologyb
ClinicalbPrinciplesbandbApplications,b
FifthbEdition,bChapterb1,bP4.
3. Whenbthebresultsbfrombthebbloodbcellbanalyzerbisbabnormalbwherebin
bthebinstrumentbprovidesbthebindicationbofbthis.b
A. Wedge-prep
B. Flag
C. Thrombocytopenia
D. ReflexbTesting
Rationale:b
Wedge-
prepbisbnotbthebanswerbbecausebitbisbabbloodbfilmbonbabglassbmicroscopebslid
ebthatbisbpreparedbbybabmicroscopistbinbbloodbfilmbexamination.
Flagbisbthebcorrectbanswerbbecausebitbisbablabbprintoutsbthatbisbabnormalbwh
ichbisbindicatedbbybabmark.
Thrombocytopeniabisbnotbthebanswerbbecausebitbisbwherebtherebisbabdecreas
edbnumberbofbplatelets.
Reflexbisbnotbthebanswerbbecausebisbanbautomaticborderingbofbtestsbbasedbo
nbpresetbparametersborbthebresultsbofbpriorbtests
Referenceb:bRodak’sbHematologyb
ClinicalbPrinciplesbandbApplications,b
SixbEdition,bChapterb1,bP5.
4. Hebisbthebfirstbscientistbtobdescribeb“worms”binbthebblood.
A. AntonbVanbLeewenhoek
B. GuiliobBizzozero
, C. AthanasiusbKircher
D. JamesbHomerbWright
Rationale:
AntonbVanbLeeuwenhoekbisbnotbthebanswerbbecausebhebdescribedbhumanbe
rythrocyte.
GuiliobBizzozerobisbnotbthebanswerbbecausebhebdescribedbplateletsbasb“petite
sbplagues”.
AthanasiusbKirsherbisbthebcorrectbanswerbbecausebhebisbthebonebwhobdescri
bedbworms.
JamesbHomerbWrightbisbnotbthebanswerbbecausebhebisbthebpersonbwhobdevel
opedbWrightbstain.
Referenceb:bRodak’sbHematologyb
ClinicalbPrinciplesbandbApplications,b
SixbEdition,bChapterb1,bP1.b
5. WhatbdobyoubcallbthebreagentbwherebHemoglobinbmeasurementbreli
esbonbabweakbsolutionbofbpotassiumbcyanidebandbpotassiumbferricya
nide.
A. Drabkinbreagent
B. Hematoxylin
C. Eosin
D. MPV
Rationale:
Drabkinbreagentbisbthebcorrectbanswerbbecausebbesidesbthatbitbisbthebonlybre
agentbinbthebchoicesbitbisbusedbinbmeasuringbhemoglobinbinbthebbloodbsampl
esbwhichbcomprisesbpotassiumbcyanidebandbpotassiumbferricyanide.
Hematoxylinbandbeosinbarebnotbthebanswerbbecausebabdyebusedbasbabhistolo
gicbstain.
MPVbalsobknownbasbMeanbPlateletbVolumebisbnotbthebanswerbbecausebitbtell
sbthebmeasurementbofbthebaveragebsizebofbplateletsbfoundbinbthebblood.
Referenceb:bRodak’sbHematologyb
ClinicalbPrinciplesbandbApplications,b
SixbEdition,bChapterb1,bP2b
, 6. Itbisbabprocessbwherebanotherbsixbtobeightbenzymesbexertbcontrolbov
erbthebcoagulationbmechanism,bandbthebthirdbsystembofbenzymesba
ndbcofactorsbdigestsbclotsbtobrestorebvesselbpatency.
A.bbCellbfragments
B. Hemostasis
C. Thrombosis
D. Fibrinolysis
Rationale:
CellbFragmentsbisbnotbthebanswerbbecausebitbisbanotherbtermbforbplatelets.
Hemostasisbisbnotbthebanswerbbecausebitbisbabseriesbofbcellularbandbplasma-
bbasedbmechanismsbthatbsealbwounds,brepairbvesselbwalls,bandbmaintainbva
scularbpatency.
Thrombosisbisbnotbthebanswerbbecausebitbisbabclotbformation.
Fibrinolysisbisbthebcorrectbanswerbbecausebitbisbabnormalbbodybprocessbthatb
preventsbbloodbclots.
Referenceb:bRodak’sbHematologyb
ClinicalbPrinciplesbandbApplications,b
SixbEdition,bChapterb1,bP5b
7. Itbisbthebratiobofbthebvolumebofbpackedbredbbloodbcellsbtobthebvolume
bofbwholebblood.
A. Hemoglobin
B. MeanbcellbHemoglobin
C. Hematocritb
D. Epitopes
Rationale:
Hemoglobinbisbnotbthebanswerbbecausebitbisbresponsiblebforboxygenbtranspo
rt.
MeanbCellbHemoglobinbisbnotbthebanswerbbecausebitbrefersbtobthebaveragebq
uantitybofbhemoglobinbpresentbinbabsinglebredbbloodbcell.
Hematocritbisbthebcorrectbanswerbbecausebitbisbthebvolumebpercentagebofbre
dbblood.
Epitopesbarebnotbthebanswerbbecausebitbisbanotherbtermbforbantigenbdetermi
nantbwhichbisbpartbofbanbantigen.