ADVANTAGE FOR
PATHOPHYSIOLOGY
INTRODUCTORY CONCEPTS AND
CLINICAL PERSPECTIVES 3RD
EDITION BY THERESA CAPRIOTTI,
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Chapter 1, The Cell in Health and Illness
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Multiple Choice
Identify the choice that best completes the statement or answers the question.
macrophages and neutrophils
Types of phagocytic cells
1. Saliva: Pathogens are weakened by the enzymes and antibacterial properties in the saliva.
2. Gastric juices: Destroys pathogens with HCL
Processes within the GI tract
Normal Flora is ______________ that live in symbiosis with the body
Natural bacteria colonies
C-diff or C-diff colitis is caused by
Abuse or misuse or antibacterials
____________________is when the normal flora in the gut is destroyed
C-diff infection (Clostridium Difficle)
Vancomycin
used to treat c. difficile. Must be taken orally for it to reach the gut.
Stool Transplant
Transplanting stool from a healthy person to the colon of a patient with repeat c.difficile infection
has been shown to successfully treat c.diff.
Tears (flushes pathogens from the eyes)
Sweat (acts as an antibacterial on the skin)
Urine (its acidity eliminates antigens from the genitourinary tract)
Bodily Secretions
The inflammatory reaction begins within seconds and can last ___________
minutes to days
__________________ is activated when the innate immunity is inadequate
Adaptive immune system
Adaptive Immunity is ______________
More specific
Adapative immunity______________, _______________, and develop memory for that specific
antigen.
recognize an antigen, and target the specific antigen
Anything that is considered non-self is what?
An antigen (foreigner)
Immunity is defined as:
The way the body defends itself against injurious agents in the environment
Immune Response is aimed to protect cells from ____________
Injurious agents (Antigens)
Innate immunity refers to natural mechanisms that ward off invaders as a___________
First Line of defense
Anatomic barriers, Processes within the GI tract, Normal flora, Bodily Fluids & Phagocytic cells
Components of Innate Immunity
Anatomical Barriers consist of ________
1. Nasal epithelium(consist of mucus producing cells and hair that traps inhaled substances)
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2. intact skin prevents infection
3. mucus membrane
Phagocytic cells engulf and ingest __________
microorganisms and other noxious substances
Human Leukocyte Antigen (HLA) allows the body to ________________
distinguish between self from non-self. Antigens that belong to the host vs antigens that are from an
invader
Human Leukocyte Antigen (HLA) aka
Major Histocompatibility complexes (MHCs)
B lymphocytes (humoral immunity) mature within the
Bone marrow, spleen, and lymph nodes
After exposure to an antigen _______________mature into plasma cells and memory B cells
B-cells
Plasma cells produce?
immunoglobulins
aka antibodies which attacks the antigens
Why are CD4 cells integral to the antibody-mediated immune response?
CD4 cells attack antigens to blunt the pathogen effect on the body.
The Increase of IgM marks what response?
The initial exposure (primary exposure)
What is released during the secondary response?
Ig G
T-Lymphocyte mature in the________
Thymus
Two types of T-cells
CD4 and CD8
Helper T-cells
CD4 cells
Cytotoxic Cells
CD8 cells
______________ influences other immune cells such as other T-cells, B-cells, NK cells, and
macropahges.
CD4 cells
CD8 cells _________ ______________ an antigen
directly attacks
HIV ___________ CD4 cells
Targets
T-cells cannot be _______________ by an antigen alone
Activated
APC cells ___________ and ___________ to antigen and __________ it before the antigen is
attacked.
Capture, attach, and process
APCs are located within the epidermis and mucous membrane ___________________
where antigens enter the body
Cytokines
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released by some APC cells
Active immune is when the body develops _____________ by stimulating the B-cells/T-cells
Immunity
Active Immunity lasts long.
True or False
True
In active Immunity, the body actively participates in the production of an_____________
antibody
Natural Active Immunity Develops
through exposure to antigen which causes an illness
Artificial Active Immunity is obtained through
Vaccinations
In Passive Immunity, the body receives the
antibodies
Passive Immunity Lasts Long
True or False
False
Memory B-cells stay in the ______________ in preparation for subsequent antigen exposure
Lymph nodes
M, G, A, E, D
Ig M
Ig G
Ig A
Ig E
Ig D
Ig G
Antiviral, antitoxin, antibacterial; can cross the placenta to the baby
Ig A
Body secretion (saliva, breastmilk etc)
Ig M
Natural antibodies for blood antigen (ABO)
Ig D
Aids in further maturation of B-cells
Ig E
Involves in parasitic infections, allergic and hypersensitivity reactions
Upon first exposure (primary response) to the antigen, the process of B-cell maturation into plasma
cells can __________ to initiate
take days (Lag time)
T-cell mediated immune response becomes more quickly activated _______
than the antibody mediated immune response.
Maternal Transfer is
Natural Passive Immunity
Ig injection used to treat immediate illness is
Artificial Passive
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