NU 636
Advanced Pharmacology
Final Exams Review (Qns & Ans)
2025
1. Which of the following is the primary mechanism of action of
beta-blockers in treating hypertension?
A. Increasing cardiac output
B. Decreasing renin secretion
C. Blocking beta-adrenergic receptors
D. Enhancing sodium excretion
ANS: C
Rationale: Beta-blockers primarily work by blocking beta-
adrenergic receptors, leading to a decrease in heart rate and
cardiac output, which helps to lower blood pressure.
©2025
,2. Which class of drugs is most commonly used to treat
hyperlipidemia by inhibiting HMG-CoA reductase?
A. Fibrates
B. Statins
C. Bile acid sequestrants
D. Niacin
ANS: B
Rationale: Statins are the most commonly used class of drugs
to treat hyperlipidemia by inhibiting HMG-CoA reductase, an
enzyme involved in cholesterol synthesis.
3. What is the primary indication for using angiotensin-
converting enzyme (ACE) inhibitors?
A. Asthma
B. Hypertension
C. Diabetes mellitus
D. Hyperthyroidism
ANS: B
Rationale: ACE inhibitors are primarily used to treat
hypertension by inhibiting the conversion of angiotensin I to
angiotensin II, resulting in vasodilation and reduced blood
pressure.
©2025
, Fill-in-the-Blank Questions
4. The antidote for acetaminophen overdose is ________.
ANS: N-acetylcysteine (NAC)
Rationale: N-acetylcysteine is the antidote for acetaminophen
overdose, as it replenishes glutathione stores and helps to detoxify
the reactive metabolite of acetaminophen.
5. Warfarin's anticoagulant effect is monitored by measuring the
________ and ________ values.
ANS: prothrombin time (PT), international normalized ratio
(INR)
Rationale: Warfarin's effect is monitored by measuring PT
and INR values to ensure therapeutic anticoagulation and prevent
bleeding complications.
True/False Questions
6. True or False: The therapeutic range of digoxin is narrow, and
toxicity can occur at relatively low serum levels.
ANS: True
©2025
Advanced Pharmacology
Final Exams Review (Qns & Ans)
2025
1. Which of the following is the primary mechanism of action of
beta-blockers in treating hypertension?
A. Increasing cardiac output
B. Decreasing renin secretion
C. Blocking beta-adrenergic receptors
D. Enhancing sodium excretion
ANS: C
Rationale: Beta-blockers primarily work by blocking beta-
adrenergic receptors, leading to a decrease in heart rate and
cardiac output, which helps to lower blood pressure.
©2025
,2. Which class of drugs is most commonly used to treat
hyperlipidemia by inhibiting HMG-CoA reductase?
A. Fibrates
B. Statins
C. Bile acid sequestrants
D. Niacin
ANS: B
Rationale: Statins are the most commonly used class of drugs
to treat hyperlipidemia by inhibiting HMG-CoA reductase, an
enzyme involved in cholesterol synthesis.
3. What is the primary indication for using angiotensin-
converting enzyme (ACE) inhibitors?
A. Asthma
B. Hypertension
C. Diabetes mellitus
D. Hyperthyroidism
ANS: B
Rationale: ACE inhibitors are primarily used to treat
hypertension by inhibiting the conversion of angiotensin I to
angiotensin II, resulting in vasodilation and reduced blood
pressure.
©2025
, Fill-in-the-Blank Questions
4. The antidote for acetaminophen overdose is ________.
ANS: N-acetylcysteine (NAC)
Rationale: N-acetylcysteine is the antidote for acetaminophen
overdose, as it replenishes glutathione stores and helps to detoxify
the reactive metabolite of acetaminophen.
5. Warfarin's anticoagulant effect is monitored by measuring the
________ and ________ values.
ANS: prothrombin time (PT), international normalized ratio
(INR)
Rationale: Warfarin's effect is monitored by measuring PT
and INR values to ensure therapeutic anticoagulation and prevent
bleeding complications.
True/False Questions
6. True or False: The therapeutic range of digoxin is narrow, and
toxicity can occur at relatively low serum levels.
ANS: True
©2025
