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Organelles
Membrane-bound compartments in eukaryotic cells with specific functions
Nuclear Localization Signal (NLS)
Positively charged sequence on proteins for nuclear import
Nuclear Pores
Protein complexes allowing selective transport in and out of the nucleus
Exportins
Proteins facilitating protein export from the nucleus
Mitochondrial Targeting Sequence (MTS)
Sequence on proteins targeting them to the mitochondria
Hsp70 Chaperone Protein
Protein aiding in keeping imported proteins unfolded during mitochondrial import
Signal Recognition Particle (SRP)
Binds to targeting sequences on proteins for translocation across membranes
Sec61
Protein complex facilitating translocation of membrane proteins into the ER
N-Linked Glycosylation
Process of adding sugars to proteins in the ER
ER-Associated Degradation (ERAD)
, Process of degrading proteins utilizing ER components
Vesicular Transport
Movement of proteins between membranes via vesicles
Clathrin Coats
Electron dense coats aiding in vesicle formation and transport
GTPases
Control coat recruitment and disassembly of coated vesicles
SNARE Proteins
Facilitate fusion of vesicle membranes during transport
Rab-GTP Proteins
Bind to effectors on target membranes to facilitate vesicle movement
Exocytosis
Process of releasing proteins into the extracellular medium
Cisternae
Flattened membrane disks in the Golgi apparatus containing different sets of enzymes
Golgi
Organelle with distinct enzyme sets for protein modification and sorting.
O-linked glycosylation
Addition of sugars to serine or threonine -OH groups.
Lysosome
Organelle with acidic environment for protein and lipid degradation.
Mannose-6-phosphate (M6P) signal
Signal added in cis-Golgi for protein recognition in trans-Golgi network.