NURS 340 Health Assessment Exam 2 2025
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Terms in this set (180)
cell wall synthesis, cell membrane permeability,
how do antibiotic drugs protein synthesis (lethal), nonlethal inhibitors of
work against bacteria? protein synthesis, synthesis of nucleic acids,
antimetabolites, viral enzyme inhibitors
toxic to microbes but harmless to host, disruption of
how do antibiotics have the bacterial cell wall, inhibition of an enzyme
selective toxicity? unique to bacteria, disruption of bacterial protein
synthesis
Enterococcus faecium, Staphylococcus aureus,
what microorganisms
Enterobacter species, Klebsiella species,
have a significant
Pseudomonas aeruginosa, Acinetobacter baumannii,
antibiotic resistance?
Clostridium difficile
- Enzymatic destruction of drug
what are the mechanisms - Prevention of penetration of drug
of antibiotic resistance? - Alteration of drug's target site
- Rapid ejection of the drug
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Treat infection, not contamination
Treat infection, not colonization
Know when to say "No to vanco"
Stop treatment when infection is cured or unlikely
Isolate the pathogen
how to delay emergence Break the chain of contagion
of drug resistance Vaccinate
Get the catheters out
Target the pathogen
Access the experts
Practice antimicrobial control
Use local data
Identify organism
Drug sensitivity of organism
Host factors
what factors contribute Host defenses
to the selection of Site of infection
antibiotics? Age
Pregnancy and lactation
Previous allergic reactions
Genetic factors
why do patients need to can lead to a drug resistant bacteria
complete the antibiotic
they are taking?
indicates that the pathogen is likely to be inhibited if
susceptible the antimicrobial compound in the blood reaches
the concentration usually achievable
indicates that the results should be considered
equivocal, and if the microorganism is not fully
susceptible to alternative, clinically feasible drugs,
intermediate the test should be repeated. This category implies
possible clinical applicability in body sites where the
drug is physiologically concentrated or in situations
where high dosage of drug can be used
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indicates that the pathogen is not likely to be
inhibited if the antimicrobial compound in the blood
resistant
reaches the concentration usually achievable; other
therapy should be considered
weaken the cell wall, causing bacteria to take up
penicillin mechanism of excessive water and rupture, active only against
action bacteria that are undergoing growth and division,
bactericidal
contain a β-lactam ring, ex. penicillin and
cephalosporins;
β-lactam ring of antibiotic fits into bacterial cell wall
beta lactam antibiotics
and inhibits transpeptidation, bacteria will eventually
rupture because the unsupported cell wall cannot
withstand its growth
how do bacteria defend some bacteria produce enzyme β-lactamase which
against beta lactam destroys the antibiotic β-lactam ring and renders
antibiotics? the antibiotic ineffective
Clavulanic acid (amoxicillin & clavulanate =
Augmentin)
Sulbactam (ampicillin & sulbactam = Unasyn)
Tazobactam (piperacillin & tazobactam = Zosyn)
what are beta lactamase
inhibitors?
by themselves they do not have antimicrobial
activity, but are combined with the antibiotic to
prevent inactivation of the antibiotic by beta
lactamases
what microbes commonly Staphylococci, Gonococci, H. influenzae,
produced beta M.catarrhalis, B.fragilis, and some
lactamase? Enterobacteriaceae
Urticaria
Pruritus
Erythematous rash
Nausea, vomiting, diarrhea
penicillin adverse effects
Headache, fatigue, dizziness
Tachycardia
Elevation of creatinine, BUN (blood urea nitrogen)
Vaginitis
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