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Organic Macromolecule Lipids

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A brief review of the organic macromolecule lipids, focusing on their structure, types, and functions. Explains the characteristics of lipids, including their hydrophobic nature, and the major types such as triglycerides, phospholipids, and steroids. Highlights their roles in energy storage, cell membrane structure, insulation, and hormone production. Includes examples like fats, oils, waxes, and cholesterol for better understanding. Ideal for students preparing for exams or studying biology and related fields. Available in digital PDF or print format.

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Lipids formed from two
phospholipid molecules.
layers of
 Lipids are biological molecules that  Membranes function to separate
are insoluble in water but soluble individual cells from their
in nonpolar solvents. environments and to
 Lipids have a wider spectrum of compartmentalize the cell interior
compositions and structures because into structures that carry out special
they are defined in terms of their functions.
physical properties (water solubility).  So important is this
 Lipids are the waxy, greasy, or oily compartmentalizing function that
compounds found in plants and membranes, and the lipids that form
animals. them, must have been essential to
 wax coating that protects the origin of life itself.
plants
 used as energy storage
 structural components (cell
membranes)
 insulation against cold

 In normal people, the amount of
lipids accounts for 25% of body
weight, and most of them are
stored in adipose tissue (aka
body fat) in the form of
triglycerides, which are variable
lipids.
 Lipoid is the basic structure of
the tissue, called basic or fixed CHEMICAL PROPERTIES
 The most chemically reactive
fat, accounting for 5% of the total
lipid content. portion of fatty acids is the
 The lipids present in various acidic carboxyl group (COOH). It
tissues are body fats, and the reacts with alcohols (R'OH) to form
body fat stores huge energy. products known as Esters (RCOOR')
and releases water in the process.
 Lipid, any of a diverse group of
 ESTER
organic compounds including fats,
 the principal covalent bond
oils, hormones, and certain
components of membranes that are linking fatty acid moieties to
grouped together because they do other groups in the more-
not interact appreciably with water. complex lipids.
 ETHER
  occurring much less
One type of lipid, the triglycerides,
is sequestered as fat in adipose frequently in biological lipids
cells, which serve as the energy- involving fatty acids
 Ether bonds are chemically
storage depot for organisms and
also provide thermal insulation. more stable than ester
bonds.
 Some lipids such as steroid
hormones serve as chemical
messengers between cells,
tissues, and organs, and others
communicate signals between
biochemical systems within a single
cell.


 The membranes of cells and
organelles (structures within cells)
are microscopically thin structures

,  A non-saponifiable class is made up
 Fatty acid ethyl esters have been of "fat-soluble" A and E vitamins
implicated as important mediators and cholesterol.
of ethanol-induced cytotoxicity,  Under basic conditions -- like
organ damage, and disease. phospholipids, glycolipids,
sphingolipids, and the waxes-- it can
 In addition, they serve as specific be hydrolyzed.
and sensitive biomarkers for
ethanol intake. Following ethanol
consumption, FAEE (fatty acid ethyl
esters) are found in circulating FATTY ACID
blood bound to albumin or/and  Saturated fatty acids
lipoproteins.  The simplest fatty acids are
unbranched, linear chains
of CH2(Methylene) groups
LIPID DIVISION linked by carbon-carbon single
1. Saponifiable lipids bonds with one terminal
 contain esters, which can carboxylic acid group.
undergo saponification  The term saturated indicates
(hydrolysis under basic that the maximum possible
conditions). number of hydrogen atoms
 Simple lipids are bonded to each carbon
 contain two types of in the molecule.
components (a fatty  Many saturated fatty acids
acid and an alcohol) have a trivial or common
 Ex: waxes, name as well as a chemically
triglycerides descriptive systematic name.
 Complex lipids
 contain more than  Unsaturated fatty acids
two components  Unsaturated fatty acids have
(fatty acids, an one or more carbon-carbon
alcohol, and other double bonds. The term
components) unsaturated indicates that
 Ex: fewer than the maximum
Phosphoglycerides, possible number of
Sphingolipids hydrogen atoms are
bonded to each carbon in
the molecule.
 The number of double
bonds is indicated by the
generic name-
monounsaturated for
molecules with one double
bond or polyunsaturated
for molecules with two or
more double bonds.
 Oleic acid (omega 9) is an
example of a
monounsaturated fatty
acid.




2. Non-saponifiable lipids
 do not contain ester groups, and
cannot be saponified (steroids,
prostaglandins)

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Geschreven in
2023/2024
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