Summary Gastrointestinal pharmacology high yield points

G charmacog ?

, tablockers > Block histamine Hareceptors oncells-
parietal
↳ cimetidine vanitidine, famotidine
~ doesn't inhibit (pyso
,




> potent inhibitor of Cyp455
> anti-androgenic effects
/gynecomastia
prolactin
,

release
flibido,

> cross BBB (Confusion)
- renal exaction of creatinine (↑Sci)
CYP450 :



- inhibition of
(yP450 means decrease metabolism ofthe
drugs leading to their
Related increase level in blood .


,


Cimetidine Warfarin : -




—> leads to decrease metabolism of warfarin, and increasing its level in blood, increasing
Its anticoagulant effect, thus the risk of bleeding.

Cimetidine-Diazepam :



—> leads to decrease metabolism of diazepam, and increasing its level inn blood, increasing its
effects, thus enhanced sedation (coma) and respiratory distress.
Cimetidine -

Clopidogrel :




—> leads to decrease antiplatelet activation, increasing its thrombotic effect.


Protein Pump inhibitors
H*/k + Atpase of parietal
cells
*Block


musean leadtaficile)
Longer PPi cannot be given
VB12 Malabsorption
·
with sucralfate and
~ Cal (Risk of Fracture)
· antifungal
· v
mg-
· - iron
· ~LtC