Biochemistry Cumulative Final Practice Questions
with Correct Answers Latest Update
What is a syndrome? - Correct Answer a group of traits typically found in
conjunction with a particular chromosomal aberration or gene mutation
What is dysplasia? - Correct Answer the presence of cells of an abnormal type
within a tissue, which may signify a stage preceding the development of cancer.
A globular, multi-pass integral membrane protein in the cytoplasmic membrane is
LEAST likely to have:
A: An asparagine residue on a surface exposed to the cytoplasm.
B: A high-mannose oligosaccharide on its extracellular surface.
C: A glutamate side chain extending into the lipid bilayer.
D: A leucine side chain in direct contact with the lipid bilayer.
E: A transmembrane alpha helix with a thirty degree tilt. - Correct Answer A
glutamate side chain extending into the lipid bilayer.
A graduate student inadvertently consumes 1200 calories of a solution of glucose
that is uniformly radioactively
labeled with 14C (all six carbons are 14C). One hour later, which of the following
molecules or moieties will
contain the LEAST amount of 14C:
A: Liver glycogen
B: Muscle glycogen
C: The fatty acid moiety of triacylglycerol in adipose tissue
D: The glycerol moiety of triacylglycerol in adipose tissue
E: Ketone bodies in the blood - Correct Answer Ketone bodies in the blood
What is the rate limiting enzyme of fatty acid synthesis? - Correct Answer Acetyl
CoA carboxylase
Acetyl CoA --> malonyl CoA - Correct Answer Acetyl CoA carboxylase in fatty acid
synthesis
HMG CoA ---> acetoacetate - Correct Answer HMG-CoA lyase in ketogenesis
A healthy adult eats a balanced meal after a 16-hour fast. One hour later, which of
the following enzymes would
be MORE active than it was just prior to eating?
A: Acetyl CoA carboxylase
B: Glucose 6-phosphatase
C: Glycogen phosphorylase a
,D: HMG CoA lyase
E: Hormone-sensitive lipase - Correct Answer Acetyl CoA carboxylase
What does this describe:
intrauterine growth restriction (IUGR), a small
face and mouth, high forehead, rocker bottom feet, and clenched fists with
overlapping fingers. - Correct Answer Trisomy 18-
Edwards syndrome
Trisomy 13 (Patau Syndrome) - Correct Answer severe cleft lip and/or palate,
microphthlamia, severe mental retardation, microcephaly, holoprosencephaly, NTDs,
polydactyly, rocker-bottom feet,
Which stage of the cell cycle corresponds with the highest levels of histone
synthesis? - Correct Answer S
Which of the following statements about amino acid side chains is TRUE?
A: Serine provides strong buffering capacity at pH 7.0.
B: Alanine absorbs ultraviolet light
C: Glutamic acid and aspartic acid differ significantly in their isoelectric point (pI).
D: Proline often produces a bend in the protein chain.
E: Only D-amino acids are incorporated into human proteins. - Correct Answer
Proline often produces a bend in the protein chain.
Which of the following is a drug used as an immune-suppressant to prevent graft
rejection? - Correct Answer Mycophenolic acid
Which of the following might be expected to result in jaundice with high levels of
unconjugated (indirect)
bilirubin?
A: obstruction of the bile duct
B: cystic fibrosis
C: Crigler-Najjar syndrome
D: pyruvate dehydrogenase deficiency
E: lead poisoning - Correct Answer Crigler-Najjar syndrome
Which of the following lipoproteins contains Apo B-100, ApoE and Apo C-II? -
Correct Answer mature VLDL
Which of the following tissues undergoes aerobic glycolysis in both the fed and
fasting states?
A: Liver
B: Erythrocytes
C: Adipose
D: Brain
E: Heart muscle - Correct Answer Brain
, What a mechanism to ACTIVATE the pyruvate dehydrogenase complex? - Correct
Answer Activation of pyruvate dehydrogenase phosphatase by Ca2+
pyruvate kinase - Correct Answer In glycolysis:
phosphoenolpyruvate --> pyruvate
Pyruvate kinase deficiency - Correct Answer ↓ ATP; RBCs dehydrated; ↑ 2,3-BPG
(right-shifted OBC)
Which of the following IMPORTS glycerol during the fasting state?
A: adipose
B: brain
C: heart muscle
D: liver
E: skeletal muscle - Correct Answer liver
Which of the following is LEAST LIKELY to be oxidized in the human body to
generate energy?
A: pyruvate
B: amylopectin
C: cholesterol
D: ethanol
E: sucrose - Correct Answer cholesterol
Amylopectin - Correct Answer branched starch
What enzyme is MOST directly responsible for generating cross-links between
mature collagen
molecules? - Correct Answer lysyl oxidase
lysyl oxidase - Correct Answer catalyze a reaction that cross-links collagen and
elastin at lysine residues
Which of the following components is present in increased amounts in lipid rafts of
the cytoplasmic membrane?
A: Free sphingosine
B: Cholesterol
C: Cardiolipin
D: Ubiquinol
E: Hyaluronan - Correct Answer cholesterol
Which of the following diseases is caused by a trinucleotide repeat that generates a
protein with an expanded
polyglutamine track.
A: spinal muscular atrophy
with Correct Answers Latest Update
What is a syndrome? - Correct Answer a group of traits typically found in
conjunction with a particular chromosomal aberration or gene mutation
What is dysplasia? - Correct Answer the presence of cells of an abnormal type
within a tissue, which may signify a stage preceding the development of cancer.
A globular, multi-pass integral membrane protein in the cytoplasmic membrane is
LEAST likely to have:
A: An asparagine residue on a surface exposed to the cytoplasm.
B: A high-mannose oligosaccharide on its extracellular surface.
C: A glutamate side chain extending into the lipid bilayer.
D: A leucine side chain in direct contact with the lipid bilayer.
E: A transmembrane alpha helix with a thirty degree tilt. - Correct Answer A
glutamate side chain extending into the lipid bilayer.
A graduate student inadvertently consumes 1200 calories of a solution of glucose
that is uniformly radioactively
labeled with 14C (all six carbons are 14C). One hour later, which of the following
molecules or moieties will
contain the LEAST amount of 14C:
A: Liver glycogen
B: Muscle glycogen
C: The fatty acid moiety of triacylglycerol in adipose tissue
D: The glycerol moiety of triacylglycerol in adipose tissue
E: Ketone bodies in the blood - Correct Answer Ketone bodies in the blood
What is the rate limiting enzyme of fatty acid synthesis? - Correct Answer Acetyl
CoA carboxylase
Acetyl CoA --> malonyl CoA - Correct Answer Acetyl CoA carboxylase in fatty acid
synthesis
HMG CoA ---> acetoacetate - Correct Answer HMG-CoA lyase in ketogenesis
A healthy adult eats a balanced meal after a 16-hour fast. One hour later, which of
the following enzymes would
be MORE active than it was just prior to eating?
A: Acetyl CoA carboxylase
B: Glucose 6-phosphatase
C: Glycogen phosphorylase a
,D: HMG CoA lyase
E: Hormone-sensitive lipase - Correct Answer Acetyl CoA carboxylase
What does this describe:
intrauterine growth restriction (IUGR), a small
face and mouth, high forehead, rocker bottom feet, and clenched fists with
overlapping fingers. - Correct Answer Trisomy 18-
Edwards syndrome
Trisomy 13 (Patau Syndrome) - Correct Answer severe cleft lip and/or palate,
microphthlamia, severe mental retardation, microcephaly, holoprosencephaly, NTDs,
polydactyly, rocker-bottom feet,
Which stage of the cell cycle corresponds with the highest levels of histone
synthesis? - Correct Answer S
Which of the following statements about amino acid side chains is TRUE?
A: Serine provides strong buffering capacity at pH 7.0.
B: Alanine absorbs ultraviolet light
C: Glutamic acid and aspartic acid differ significantly in their isoelectric point (pI).
D: Proline often produces a bend in the protein chain.
E: Only D-amino acids are incorporated into human proteins. - Correct Answer
Proline often produces a bend in the protein chain.
Which of the following is a drug used as an immune-suppressant to prevent graft
rejection? - Correct Answer Mycophenolic acid
Which of the following might be expected to result in jaundice with high levels of
unconjugated (indirect)
bilirubin?
A: obstruction of the bile duct
B: cystic fibrosis
C: Crigler-Najjar syndrome
D: pyruvate dehydrogenase deficiency
E: lead poisoning - Correct Answer Crigler-Najjar syndrome
Which of the following lipoproteins contains Apo B-100, ApoE and Apo C-II? -
Correct Answer mature VLDL
Which of the following tissues undergoes aerobic glycolysis in both the fed and
fasting states?
A: Liver
B: Erythrocytes
C: Adipose
D: Brain
E: Heart muscle - Correct Answer Brain
, What a mechanism to ACTIVATE the pyruvate dehydrogenase complex? - Correct
Answer Activation of pyruvate dehydrogenase phosphatase by Ca2+
pyruvate kinase - Correct Answer In glycolysis:
phosphoenolpyruvate --> pyruvate
Pyruvate kinase deficiency - Correct Answer ↓ ATP; RBCs dehydrated; ↑ 2,3-BPG
(right-shifted OBC)
Which of the following IMPORTS glycerol during the fasting state?
A: adipose
B: brain
C: heart muscle
D: liver
E: skeletal muscle - Correct Answer liver
Which of the following is LEAST LIKELY to be oxidized in the human body to
generate energy?
A: pyruvate
B: amylopectin
C: cholesterol
D: ethanol
E: sucrose - Correct Answer cholesterol
Amylopectin - Correct Answer branched starch
What enzyme is MOST directly responsible for generating cross-links between
mature collagen
molecules? - Correct Answer lysyl oxidase
lysyl oxidase - Correct Answer catalyze a reaction that cross-links collagen and
elastin at lysine residues
Which of the following components is present in increased amounts in lipid rafts of
the cytoplasmic membrane?
A: Free sphingosine
B: Cholesterol
C: Cardiolipin
D: Ubiquinol
E: Hyaluronan - Correct Answer cholesterol
Which of the following diseases is caused by a trinucleotide repeat that generates a
protein with an expanded
polyglutamine track.
A: spinal muscular atrophy
